Adrenomedullin is a potent vasodilator peptide that was originally isolated from human
pheochromocytoma.
1
Recently, adrenomedullin production and secretion have been reported in both endothelial
cells
2
and vascular smooth muscle cells.
3
Sabates et al
4
demonstrated that the direct injection of adrenomedullin into the coronary artery
produced an increase in coronary blood flow. These findings suggest that adrenomedullin
may contribute to the control of coronary circulation. It has been suggested that
vasospastic angina pectoris (VAP) is involved in endothelial injury or atherosclerosis,
even though some of them appear to be normal angiographically. The precise mechanism
of coronary artery spasm has not been revealed, but it has been suggested that vasoactive
substances, including endothelin-1
5
and nitric oxide (NO)
6
may be involved in the pathogenesis of VAP. This pilot study elucidates the role
of adrenomedullin in VAP.To read this article in full you will need to make a payment
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References
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- Elevation of cardiac and ventricular adrenomedullin in human congestive heart failure.Circulation. 1995; 92: 286-289
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Article Info
Publication History
Published online: August 16, 2004
Accepted:
September 27,
1999
Received in revised form:
September 27,
1999
Received:
August 6,
1999
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
