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Predictive value of C-reactive protein in patients with unstable angina pectoris undergoing coronary artery stent implantation

      Systemic signs of inflammation are present in most patients with acute coronary syndromes.
      • Berk B.C
      • Wientraub W.S
      • Alexander R.W
      Elevation of C-reactive protein in “active” coronary artery disease.
      ,
      • de Beer F.C
      • Hind C.R.K
      • Fox K.M
      • Allan R.M
      • Maseri A
      • Pepys M.B
      Measurement of serum C-reactive protein concentration in myocardial ischemia and infarction.
      ,
      • Liuzzo G
      • Biasiucci L.M
      • Gallimore J.R
      • Grillo R.L
      • Rebuzzi A.G
      • Pepys M.B
      • Maseri A
      The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina.
      Inflammation has also been shown to play a key role in the pathogenesis of in-stent restenosis because it promotes neointimal proliferation, the prevailing mechanism of restenosis after stenting.
      • Pietersma A
      • Kofflard M
      • de Wit E.A
      • Stijnen T
      • Koster J.F
      • Serruys P.W
      • Sluiter W
      Late lumen loss after coronary angioplasty is associated with the activation status of circulating phagocytes before treatment.
      ,
      • Hoffman R
      • Mintz G.S
      • Dussailant G.R
      • Popma J.J
      • Pichard A.D
      • Satler L.F
      • Kent K.M
      • Griffin J
      • Leon M.B
      Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study.
      In this study we question whether the intensity of preprocedural inflammatory activation, assessed by measuring C-reactive protein (CRP) (a prototype acute-phase reactant
      • Pepys M.B
      C-reactive protein fifty years on.
      ) in patients with unstable angina undergoing successful coronary artery stenting, can predict the risk of cardiac events at follow-up.
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