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Effects of components of meals (carbohydrate, fat, protein) in causing postprandial exertional angina pectoris

  • Ragavendra R. Baliga
    Affiliations
    From the Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom

    From the Wynn Institute for Metabolic Research, London, United Kingdom

    From the Department of Physiology, St. Mary's Hospital Medical School, Norfolk Place, London, United Kingdom
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  • Leah Burden
    Affiliations
    From the Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom

    From the Wynn Institute for Metabolic Research, London, United Kingdom

    From the Department of Physiology, St. Mary's Hospital Medical School, Norfolk Place, London, United Kingdom
    Search for articles by this author
  • Mandeep K. Sidhu
    Affiliations
    From the Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom

    From the Wynn Institute for Metabolic Research, London, United Kingdom

    From the Department of Physiology, St. Mary's Hospital Medical School, Norfolk Place, London, United Kingdom
    Search for articles by this author
  • Michael W. Rampling
    Affiliations
    From the Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom

    From the Wynn Institute for Metabolic Research, London, United Kingdom

    From the Department of Physiology, St. Mary's Hospital Medical School, Norfolk Place, London, United Kingdom
    Search for articles by this author
  • Jaspal S. Kooner
    Footnotes
    Affiliations
    From the Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom

    From the Wynn Institute for Metabolic Research, London, United Kingdom

    From the Department of Physiology, St. Mary's Hospital Medical School, Norfolk Place, London, United Kingdom
    Search for articles by this author
  • Author Footnotes
    1 Dr. Kooner's address is: Division of Cardiology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W120NN.
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      Abstract

      We have shown that unlike fat, protein, xylose, or water, the carbohydrate component of the meal accelerates myocardial ischemia, reduces exercise capacity, and is associated with a more rapid increase in the determinants of myocardial oxygen consumption than exercise in the fasting state. Our results suggest a role for a larger increase in sympathetic nervous activity and/or release of vasoactive gastrointestinal peptides after carbohydrates than after other test meals in postprandial angina.
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