In the extended follow-up of the Everolimus-Eluting Stents Versus Bare-Metal Stents
in ST-Segment Elevation Myocardial Infarction (EXAMINATION) trial, Arévalos et al
1
describe the age-related outcomes in a cohort of patients with ST-elevation myocardial
infarction (STEMI). The primary aim of this trial was to study the impact of drug-eluting
stents (DES; everolimus) versus that of bare-metal stents (BMS) in patients with early
presentation of STEMI. This was an all-comer, multicenter, prospective, randomized,
2-arm, single-blind, controlled trial conducted at 12 academic hospital centers in
3 European countries. In the initial, nearly 1,500 patients cohort, this study showed
the superiority of DES over BMS at 5 years and was subsequently lengthened to 10 years
in the EXAMINATION-EXTEND. This particular substudy of 1,375 patients aimed to assess
10-year patient-oriented composite end point of all-cause death, any myocardial infarction
(MI), or any revascularization after STEMI, when stratified by age into 4 groups:
<55, 55 to 65, 65 to 75, and >75 years.
- Arévalos V
- Spione F
- Gabani R
- Ortega-Paz L
- Gómez-Lara J
- Jiménez-Díaz V
- Jiménez M
- Jiménez-Quevedo P
- Diletti R
- Pineda J
- Campo G
- Silvestro A
- Maristany J
- Flores X
- Oyarzabal L
- Bastos-Fernandez G
- Iñiguez A
- Serra A
- Escaned J
- Ielasi A
- Tespili M
- Lenzen M
- Fernández-Ortiz A
- Bordes P
- Tebaldi M
- Biscaglia S
- Al-Shaibani S
- Romaguera R
- Gómez-Hospital JA
- Rodes-Cabau J
- Serruys PW
- Sabaté M
- Brugaletta S.
Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year
outcomes (from the EXAMINATION EXTEND trial).
Am J Cardiol. 2022; 190: 32-40
1
Importantly, patients with previous coronary artery disease (CAD) were excluded from
this analysis because those patients were correctly considered at higher risk for
repeat events in such an extended follow-up.- Arévalos V
- Spione F
- Gabani R
- Ortega-Paz L
- Gómez-Lara J
- Jiménez-Díaz V
- Jiménez M
- Jiménez-Quevedo P
- Diletti R
- Pineda J
- Campo G
- Silvestro A
- Maristany J
- Flores X
- Oyarzabal L
- Bastos-Fernandez G
- Iñiguez A
- Serra A
- Escaned J
- Ielasi A
- Tespili M
- Lenzen M
- Fernández-Ortiz A
- Bordes P
- Tebaldi M
- Biscaglia S
- Al-Shaibani S
- Romaguera R
- Gómez-Hospital JA
- Rodes-Cabau J
- Serruys PW
- Sabaté M
- Brugaletta S.
Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year
outcomes (from the EXAMINATION EXTEND trial).
Am J Cardiol. 2022; 190: 32-40
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References
- Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year outcomes (from the EXAMINATION EXTEND trial).Am J Cardiol. 2022; 190: 32-40
Social Security. Actuarial life table. Available at: http://ssa.gov/oact/STATS/table4c6.html. Accessed on December 2, 2022.
- Long-term survival in octogenarians and older patients with ST-elevation myocardial infarction in the era of primary angioplasty: a prospective cohort study.Eur Heart J Acute Cardiovasc Care. 2016; 5 ([published correction appears in Eur Heart J Acute Cardiovasc Care 2021;10:584]): 243-252
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- 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Circulation. 2022; 145: e895-e1032
- Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: next Steps).J Am Coll Cardiol. 2014; 63: 1145-1155
- The EXAMINATION trial (everolimus-Eluting Stents versus Bare-Metal Stents in ST-Segment Elevation myocardial infarction): 2-year results from a multicenter randomized controlled trial.JACC Cardiovasc Interv. 2014; 7: 64-71
- 1-month dual-antiplatelet therapy followed by aspirin monotherapy after polymer-free drug-coated stent implantation: one-month DAPT trial.JACC Cardiovasc Interv. 2021; 14: 1801-1811
- Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial.Lancet. 2018; 391: 41-50
Article info
Publication history
Published online: January 20, 2023
Received:
December 22,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: none.
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
