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Extending Our Knowledge of Lifetime Outcomes After ST-Elevation Myocardial Infarction

Published:January 20, 2023DOI:https://doi.org/10.1016/j.amjcard.2023.01.003
      In the extended follow-up of the Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction (EXAMINATION) trial, Arévalos et al
      • Arévalos V
      • Spione F
      • Gabani R
      • Ortega-Paz L
      • Gómez-Lara J
      • Jiménez-Díaz V
      • Jiménez M
      • Jiménez-Quevedo P
      • Diletti R
      • Pineda J
      • Campo G
      • Silvestro A
      • Maristany J
      • Flores X
      • Oyarzabal L
      • Bastos-Fernandez G
      • Iñiguez A
      • Serra A
      • Escaned J
      • Ielasi A
      • Tespili M
      • Lenzen M
      • Fernández-Ortiz A
      • Bordes P
      • Tebaldi M
      • Biscaglia S
      • Al-Shaibani S
      • Romaguera R
      • Gómez-Hospital JA
      • Rodes-Cabau J
      • Serruys PW
      • Sabaté M
      • Brugaletta S.
      Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year outcomes (from the EXAMINATION EXTEND trial).
      describe the age-related outcomes in a cohort of patients with ST-elevation myocardial infarction (STEMI). The primary aim of this trial was to study the impact of drug-eluting stents (DES; everolimus) versus that of bare-metal stents (BMS) in patients with early presentation of STEMI. This was an all-comer, multicenter, prospective, randomized, 2-arm, single-blind, controlled trial conducted at 12 academic hospital centers in 3 European countries. In the initial, nearly 1,500 patients cohort, this study showed the superiority of DES over BMS at 5 years and was subsequently lengthened to 10 years in the EXAMINATION-EXTEND. This particular substudy of 1,375 patients aimed to assess 10-year patient-oriented composite end point of all-cause death, any myocardial infarction (MI), or any revascularization after STEMI, when stratified by age into 4 groups: <55, 55 to 65, 65 to 75, and >75 years.
      • Arévalos V
      • Spione F
      • Gabani R
      • Ortega-Paz L
      • Gómez-Lara J
      • Jiménez-Díaz V
      • Jiménez M
      • Jiménez-Quevedo P
      • Diletti R
      • Pineda J
      • Campo G
      • Silvestro A
      • Maristany J
      • Flores X
      • Oyarzabal L
      • Bastos-Fernandez G
      • Iñiguez A
      • Serra A
      • Escaned J
      • Ielasi A
      • Tespili M
      • Lenzen M
      • Fernández-Ortiz A
      • Bordes P
      • Tebaldi M
      • Biscaglia S
      • Al-Shaibani S
      • Romaguera R
      • Gómez-Hospital JA
      • Rodes-Cabau J
      • Serruys PW
      • Sabaté M
      • Brugaletta S.
      Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year outcomes (from the EXAMINATION EXTEND trial).
      Importantly, patients with previous coronary artery disease (CAD) were excluded from this analysis because those patients were correctly considered at higher risk for repeat events in such an extended follow-up.
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      References

        • Arévalos V
        • Spione F
        • Gabani R
        • Ortega-Paz L
        • Gómez-Lara J
        • Jiménez-Díaz V
        • Jiménez M
        • Jiménez-Quevedo P
        • Diletti R
        • Pineda J
        • Campo G
        • Silvestro A
        • Maristany J
        • Flores X
        • Oyarzabal L
        • Bastos-Fernandez G
        • Iñiguez A
        • Serra A
        • Escaned J
        • Ielasi A
        • Tespili M
        • Lenzen M
        • Fernández-Ortiz A
        • Bordes P
        • Tebaldi M
        • Biscaglia S
        • Al-Shaibani S
        • Romaguera R
        • Gómez-Hospital JA
        • Rodes-Cabau J
        • Serruys PW
        • Sabaté M
        • Brugaletta S.
        Impact of age at the time of the first ST-Elevation myocardial infarction on 10-year outcomes (from the EXAMINATION EXTEND trial).
        Am J Cardiol. 2022; 190: 32-40
      1. Social Security. Actuarial life table. Available at: http://ssa.gov/oact/STATS/table4c6.html. Accessed on December 2, 2022.

        • Kvakkestad KM
        • Abdelnoor M
        • Claussen PA
        • Eritsland J
        • Fossum E
        • Halvorsen S.
        Long-term survival in octogenarians and older patients with ST-elevation myocardial infarction in the era of primary angioplasty: a prospective cohort study.
        Eur Heart J Acute Cardiovasc Care. 2016; 5 ([published correction appears in Eur Heart J Acute Cardiovasc Care 2021;10:584]): 243-252
        • Spoon DB
        • Psaltis PJ
        • Singh M
        • Holmes Jr, DR
        • Gersh BJ
        • Rihal CS
        • Lennon RJ
        • Moussa ID
        • Simari RD
        • Gulati R.
        Trends in cause of death after percutaneous coronary intervention.
        Circulation. 2014; 129: 1286-1294
        • Heidenreich PA
        • Bozkurt B
        • Aguilar D
        • Allen LA
        • Byun JJ
        • Colvin MM
        • Deswal A
        • Drazner MH
        • Dunlay SM
        • Evers LR
        • Fang JC
        • Fedson SE
        • Fonarow GC
        • Hayek SS
        • Hernandez AF
        • Khazanie P
        • Kittleson MM
        • Lee CS
        • Link MS
        • Milano CA
        • Nnacheta LC
        • Sandhu AT
        • Stevenson LW
        • Vardeny O
        • Vest AR
        • Yancy CW.
        2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
        Circulation. 2022; 145: e895-e1032
        • Nørgaard BL
        • Leipsic J
        • Gaur S
        • Seneviratne S
        • Ko BS
        • Ito H
        • Jensen JM
        • Mauri L
        • De Bruyne B
        • Bezerra H
        • Osawa K
        • Marwan M
        • Naber C
        • Erglis A
        • Park SJ
        • Christiansen EH
        • Kaltoft A
        • Lassen JF
        • Bøtker HE
        • Achenbach S
        • NXT Trial Study Group
        Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: next Steps).
        J Am Coll Cardiol. 2014; 63: 1145-1155
        • Sabaté M
        • Brugaletta S
        • Cequier A
        • Iñiguez A
        • Serra A
        • Hernádez-Antolín R
        • Mainar V
        • Valgimigli M
        • Tespili M
        • den Heijer P
        • Bethencourt A
        • Vázquez N
        • Backx B
        • Serruys PW.
        The EXAMINATION trial (everolimus-Eluting Stents versus Bare-Metal Stents in ST-Segment Elevation myocardial infarction): 2-year results from a multicenter randomized controlled trial.
        JACC Cardiovasc Interv. 2014; 7: 64-71
        • Hong SJ
        • Kim JS
        • Hong SJ
        • Lim DS
        • Lee SY
        • Yun KH
        • Park JK
        • Kang WC
        • Kim YH
        • Yoon HJ
        • Won H
        • Nam CM
        • Ahn CM
        • Kim BK
        • Ko YG
        • Choi D
        • Jang Y
        • Hong MK
        • One-Month DAPT Investigators
        1-month dual-antiplatelet therapy followed by aspirin monotherapy after polymer-free drug-coated stent implantation: one-month DAPT trial.
        JACC Cardiovasc Interv. 2021; 14: 1801-1811
        • Varenne O
        • Cook S
        • Sideris G
        • Kedev S
        • Cuisset T
        • Carrié D
        • Hovasse T
        • Garot P
        • El Mahmoud R
        • Spaulding C
        • Helft G
        • Diaz Fernandez JF
        • Brugaletta S
        • Pinar-Bermudez E
        • Mauri Ferre J
        • Commeau P
        • Teiger E
        • Bogaerts K
        • Sabate M
        • Morice MC
        • Sinnaeve PR
        • SENIOR Investigators
        Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial.
        Lancet. 2018; 391: 41-50