Advertisement
Research Article| Volume 192, P79-87, April 01, 2023

Download started.

Ok

Meta-Analysis Comparing Outcomes of Remote Hemodynamic Assessment Versus Standard Care in Patients With Heart Failure

Published:February 07, 2023DOI:https://doi.org/10.1016/j.amjcard.2022.12.033
      In patients with congestive heart failure (CHF), remote hemodynamic monitoring can reduce heart failure exacerbation and mortality. In this study, we compared the effectiveness of remote hemodynamic monitoring with that of standard care in the management of patients with CHF. The remote monitoring group included 7,733 patients, and the control group included 7,567 patients. Chi-square test and I-square statistics were used to assess heterogeneity. Risk ratios (RRs) were calculated using fixed-effects and random-effects methods to determine the risk of all-cause hospitalization and CHF-related hospitalization (primary outcomes) and all-cause mortality and device outcomes (secondary outcomes). Pooled findings indicated a 7% lower risk of all-cause hospitalization in the remote monitoring group than that in the control group (RR 0.93, 95% confidence interval [CI] 0.89 to 0.98, p = 0.004). The results also revealed a 32% lower risk of CHF-related hospitalization in the remote monitoring group than that in the control group (RR 0.68, 95% CI 0.65 to 0.71, p <0.001). No statistically significant differences were noted between the groups in terms of all-cause mortality (RR 0.97, 95% CI 0.87 to 1.07, p = 0.53) and device outcomes (RR 1.23 95% CI 0.92 to 1.65, p = 0.16). These results provided evidence regarding the comparable effectiveness of remote CHF monitoring and routine care. The current evidence is insufficient to introduce remote hemodynamic CHF monitoring; however, our results suggest that the integration of telemonitoring systems with routine medical management may improve heart failure care.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hopper I
        • Easton K
        Chronic heart failure.
        Aust Prescr. 2017; 40: 128-136
        • Inamdar AA
        • Inamdar AC
        Heart failure: diagnosis, management and utilization.
        J Clin Med. 2016; 5: 62
        • Savarese G
        • Lund LH
        Global public health burden of heart failure.
        Card Fail Rev. 2017; 3: 7-11
        • Adamson PB
        • Ginn G
        • Anker SD
        • Bourge RC
        • Abraham WTTl
        Remote haemodynamic-guided care for patients with chronic heart failure: a meta-analysis of completed trials.
        Eur J Heart Fail. 2017; 19: 426-433
        • Alotaibi S
        • Hernandez-Montfort J
        • Ali OE
        • El-Chilali K
        • Perez BA
        Remote monitoring of implantable cardiac devices in heart failure patients: a systematic review and meta-analysis of randomized controlled trials.
        Heart Fail Rev. 2020; 25: 469-479
        • Page MJ
        • McKenzie JE
        • Bossuyt PM
        • Boutron I
        • Hoffmann TC
        • Mulrow CD
        • Shamseer L
        • Tetzlaff JM
        • Akl EA
        • Brennan SE
        • Chou R
        • Glanville J
        • Grimshaw JM
        • Hróbjartsson A
        • Lalu MM
        • Li T
        • Loder EW
        • Mayo-Wilson E
        • Mcdonald S
        • McGuinness LA
        • Stewart LA
        • Thomas J
        • Tricco AC
        • Welch VA
        • Whiting P
        • Moher D
        The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.
        BMJ. 2021; 372: n71
        • Li Z
        A power formula for the Mantel–Haenszel test for differential item functioning.
        Appl Psychol Meas. 2015; 39: 373-388
        • Kim HY
        Statistical notes for clinical researchers: chi-squared test and Fisher's exact test.
        Restor Dent Endod. 2017; 42: 152-155
        • Ahn E
        • Kang H
        Introduction to systematic review and meta-analysis.
        Korean J Anesthesiol. 2018; 71: 103-112
        • Abraham WT
        • Adamson PB
        • Bourge RCm Aaron MF
        • Costanzo MR
        • Stevenson LW
        • Strickland W
        • Neelagaru S
        • Raval N
        • Krueger S
        • Weinder S
        • Shavelle D
        • Jeffries B
        • Yadav JS
        Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial.
        Lancet. 2011; 377: 658-666
        • Abraham J
        • Bharmi R
        • Jonsson O
        • Oliveira GH
        • Artis A
        • Valika A
        • Capodilupo R
        • Adamson PB
        • Roberts G
        • Dalal N
        • Desai AS
        • Benza RL
        Association of ambulatory hemodynamic monitoring of heart failure with clinical outcomes in a concurrent matched cohort analysis.
        JAMA Cardiol. 2019; 4: 556-563
        • Adamson PB
        • Gold MR
        • Bennett T
        • Bourge RC
        • Stevenson LW
        • Trupp R
        • Stromberg K
        • Wilkoff BL
        • Costanzo MR
        • Luby A
        • Aranda JM
        • Heywood JT
        • Baldwin HA
        • Aaron M
        • Smith A
        • Zile M
        Continuous hemodynamic monitoring in patients with mild to moderate heart failure: results of the reducing decompensation events utilizing intracardiac pressures in patients with chronic heart failure (REDUCEhf) trial.
        Congest Heart Fail. 2011; 17: 248-254
        • Assaad M
        • Sarsam S
        • Naqvi A
        • Zughaib M
        CardioMems® device implantation reduces repeat hospitalizations in heart failure patients: a single center experience.
        JRSM Cardiovasc Dis. 2019; 82048004019833290
        • Desai AS
        • Bhimaraj A
        • Bharmi R
        • Jermyn R
        • Bhatt K
        • Shavelle D
        • Redfield MM
        • Hull R
        • Pelzel J
        • Davis K
        • Dalal N
        • Adamson PB
        • Heywood JT
        Ambulatory hemodynamic monitoring reduces heart failure hospitalizations in “Real-World” clinical practice.
        J Am Coll Cardiol. 2017; 69: 2357-2365
        • Hale TM
        • Jethwani K
        • Kandola MS
        • Saldana F
        • Kvedar JC
        A remote medication monitoring system for chronic heart failure patients to reduce readmissions: a two-arm randomized Pilot study [published correction appears in J Med Internet Res 2019;21:e13125].
        J Med Internet Res. 2016; 18: e91
        • Johnson AE
        • Bilderback A
        • Boninger M
        • Beatty KY
        • Bellon J
        • Leopold MC
        • Watson AR
        • Ramani RN
        Remote monitoring for heart failure: assessing the risks of readmission and mortality.
        Am Heart J Plus. 2021; 10100045
        • Landolina M
        • Perego GB
        • Lunati M
        • Curnis A
        • Guenzati G
        • Vicentini A
        • Parati G
        • Borghi G
        • Zanaboni P
        • Valsecchi S
        • Marzegalli M
        Remote monitoring reduces healthcare use and improves quality of care in heart failure patients with implantable defibrillators: The evolution of management strategies of heart failure patients with implantable defibrillators (EVOLVO) study.
        Circulation. 2012; 125: 2985-2992
        • Morgan JM
        • Kitt S
        • Gill J
        • McComb JM
        • Ng GA
        • Raftery J
        • Roderick P
        • Seed A
        • Williams SG
        • Witte KK
        • Wright DJ
        • Harris S
        • Cowie MR
        Remote management of heart failure using implantable electronic devices.
        Eur Heart J. 2017; 38: 2352-2360
        • Shavelle DM
        • Desai AS
        • Abraham WT
        • Bourge RC
        • Raval N
        • Rathman LD
        • Heywood JT
        • Jermyn RA
        • Pelzel J
        • Jonsson OT
        • Costanzo MR
        • Henderson JD
        • Brett ME
        • Adamson PB
        • Stevenson LW
        • CardioMEMS Post-Approval Study Investigators
        Lower rates of heart failure and all-cause hospitalizations during pulmonary artery pressure-guided therapy for ambulatory heart failure: One-Year Outcomes From the CardioMEMS Post-Approval Study.
        Circ Heart Fail. 2020; 13e006863
        • Zile MR
        • Bourge RC
        • Bennett TD
        • Stevenson LW
        • Cho YK
        • Adamson PB
        • Aaron MF
        • Aranda JM
        • Abraham WT
        • Smart FW
        • Kueffer FJ
        Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial.
        J Card Fail. 2008; 14: 816-823
        • Adamson PB
        • Abraham WT
        • Stevenson LW
        • Desai AS
        • Lindenfeld J
        • Bourge RC
        • Bauman J
        Pulmonary artery pressure–guided heart failure management reduces 30-day readmissions.
        Circ Heart Fail. 2016; 9e002600
        • Bourge RC
        • Abraham WT
        • Adamson PB
        • Aaron MF
        • Aranda JM
        • Magalski A
        • Zile MR
        • Smith AL
        • Smart FW
        • O'Shaughnessy MA
        • Jessup ML
        • Sparks B
        • Naftel DL
        • Stevenson LW
        • COMPASS-HF Study Group
        Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: The COMPASS-HF study.
        J Am Coll Cardiol. 2008; 51: 1073-1079
        • Cowie A
        • Thow MK
        • Granat MH
        • Mitchell SL
        Effects of home versus hospital-based exercise training in chronic heart failure.
        Int J Cardiol. 2012; 158: 296-298
        • van Veldhuisen DJ
        • Braunschweig F
        • Conraads V
        • Ford I
        • Cowie MR
        • Jondeau G
        • Kautzner J
        • Aguilera RM
        • Lunati M
        • Yu CM
        • Gerritse B
        • Borggrefe M
        • DOT-HF Investigators
        Intrathoracic impedance monitoring, audible patient alerts, and outcome in patients with heart failure.
        Circulation. 2011; 124: 1719-1726
        • Domenichini G
        • Rahneva T
        • Diab IG
        • Dhillon OS
        • Campbell NG
        • Finlay MC
        • Baker V
        • Hunter RJ
        • Earley MJ
        • Schilling RJ
        The lung impedance monitoring in treatment of chronic heart failure (the LIMIT-CHF study).
        Europace. 2016; 18: 428-435
        • Givertz MM
        • Stevenson LW
        • Costanzo MR
        • Bourge RC
        • Bauman JG
        • Ginn G
        • Abraham WT
        • CHAMPION Trial Investigators
        Pulmonary artery pressure-guided management of patients with heart failure and reduced ejection fraction.
        J Am Coll Cardiol. 2017; 70: 1875-1886
        • Hansen C
        • Loges C
        • Seidl K
        • Eberhardt F
        • Tröster H
        • Petrov K
        • Grönefeld G
        • Bramlage P
        • Birkenhauer F
        • Weiss C
        INvestigation on routine follow-up in congestive heart failure patients with remotely monitored implanted cardioverter defibrillators SysTems (InContact).
        BMC Cardiovasc Disord. 2018; 18: 131
        • Hindricks G
        • Taborsky M
        • Glikson M
        • Heinrich U
        • Schumacher B
        • Katz A
        • Brachmann J
        • Lewalter T
        • Goette A
        • Block M
        • Kautzner J
        • Sack S
        • Husser D
        • Piorkowski C
        • Søgaard P
        • IN-TIME study group*
        Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised controlled trial.
        Lancet. 2014; 384: 583-590
        • Jermyn R
        • Alam A
        • Kvasic J
        • Saeed O
        • Jorde U
        Hemodynamic-guided heart-failure management using a wireless implantable sensor: infrastructure, methods, and results in a community heart failure disease-management program.
        Clin Cardiol. 2017; 40: 170-176
        • Krahnke JS
        • Abraham WT
        • Adamson PB
        • Bourge RC
        • Bauman J
        • Ginn G
        • Martinez FJ
        • Criner GJ
        • CHAMPION Trial Study Group
        Heart failure and respiratory hospitalizations are reduced in patients with heart failure and chronic obstructive pulmonary disease with the use of an implantable pulmonary artery pressure monitoring device.
        J Card Fail. 2015; 21: 240-249
        • Lindenfeld J
        • Zile MR
        • Desai AS
        • Bhatt K
        • Ducharme A
        • Horstmanshof D
        • Krim S
        • Maisel A
        • Mehra MR
        • Paul S
        • Sears SF
        • Sauer AJ
        • Smart F
        • Zughaib M
        • Castaneda P
        • Kelly J
        • Johnson N
        • Zood P
        • Ginn G
        • Henderson J
        • Adamson PB
        • Costanzo MR
        Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial.
        Lancet. 2021; 398: 991-1001
        • Lüthje L
        • Vollmann D
        • Seegers J
        • Sohns C
        • Hasenfuß G
        • Zabel M.
        A randomized study of remote monitoring and fluid monitoring for the management of patients with implanted cardiac arrhythmia devices.
        Europace. 2015; 17: 1276-1281
        • Sardu C
        • Santamaria M
        • Rizzo MR
        • Barbieri M
        • di Marino MD
        • Paolisso G
        • Santulli G
        • Marfella R
        Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-D): the TELECART Study.
        Int J Clin Pract. 2016; 70: 569-576
        • Varma N
        • Bourge RC
        • Stevenson LW
        • Costanzo MR
        • Shavelle D
        • Adamson PB
        • Ginn G
        • Henderson J
        • Abraham WT
        • CHAMPION Investigator Group
        Remote hemodynamic-guided therapy of patients with recurrent heart failure following cardiac resynchronization therapy.
        J Am Heart Assoc. 2021; 10e017619
        • Tse G
        • Chan C
        • Gong M
        • Meng L
        • Zhang J
        • Su XL
        • Al-Saegh S
        • Sawant AC
        • Bazoukis G
        • Zia YL
        • Zhao J
        • Lee APW
        • Roever L
        • Wong MC
        • Baranchuk A
        • Liu T
        Telemonitoring and hemodynamic monitoring to reduce hospitalization rates in heart failure: a systematic review and meta-analysis of randomized controlled trials and real-world studies.
        J Geriatr Cardiol. 2018; 15: 298-309
        • Hajduczok AG
        • Muallem SN
        • Nudy MS
        • DeWaters AL
        • Boehmer JP
        Remote monitoring for heart failure using implantable devices: a systematic review, meta-analysis, and meta-regression of randomized controlled trials.
        Heart Fail Rev. 2022; 27: 1281-1300