The redox state of human serum albumin (HSA) is reported to be an oxidative stress
biomarker; however, its clinical use in cardiac disease has not yet been examined.
This study aimed to investigate the relation between the redox state of HSA and exercise
capacity, which is a robust prognostic factor, in patients with cardiovascular disease.
This cross-sectional study included outpatients with cardiac disease. Exercise capacity
was assessed by peak oxygen consumption (peakVO2) measured using symptom-limited cardiopulmonary exercise testing. The high-performance
liquid chromatography postcolumn bromocresol green method was used to part HSA into
human nonmercaptalbumin (oxidized form) and human mercaptalbumin (HMA, reduced form).
The fraction of human mercaptalbumin found in HSA (f[HMA]) was calculated as an indicator
of the redox state of HSA. The association between peakVO2 and f(HMA) was examined using the Spearman correlation coefficient and multivariate
linear regression analysis. A total of 70 patients were included (median age 76 years;
44 men; median peakVO2 15.5 ml/kg/min). The f(HMA) was positively correlated with peakVO2 (r = 0.38, p <0.01). Even after controlling for potential confounders, this association
remained in the multivariate linear regression analysis (standardized beta = 0.24,
p <0.05). We found a positive association between f(HMA) and peakVO2, independent of potential confounders in patients with cardiac disease, suggesting
that f(HMA) may be a novel biomarker related to exercise capacity in cardiac disease.
Longitudinal studies are required to further examine the prognostic capability of
f(HMA), the responsiveness to clinical intervention, and the association between f(HMA)
and cardiac disease.
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Article info
Publication history
Published online: December 09, 2022
Received in revised form:
October 10,
2022
Received:
June 21,
2022
Footnotes
Funding: This work was supported by the grant No.: 17-005) from the Suzuken Memorial Foundation (Nagoya, Aichi, Japan) (The sponsor played no role in the collection, analysis, and interpretation of data; in writing the report; and in the decision to submit the article for publication.)
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