Children and adults with congenital heart disease (CHD) are increasingly recognized
to be at risk for acute and chronic renal injury. Some of these may progress to the
need for renal transplantation. We hypothesized that patients with underlying moderate
or severe CHD who undergo renal transplantation will have worse acute hospital outcomes.
Using a national administrative database, we queried for admissions aged 0 to 50 years
with moderate or severe CHD and renal transplantation and compared these to admissions
without CHD. There were 56 admissions for renal transplantation in the CHD group (0.04%)
and 26,285 admissions in the group without CHD (0.21%, p<0.001). The CHD group were
younger, had a higher proportion of Whites, longer length of stay, higher complication
rates, higher in-hospital mortality, and higher costs. In conclusion, although renal
transplantation is still relatively uncommon in the CHD population, there is an increasing
recognition of severe chronic renal disease in the setting of CHD, making it important
to understand the potential implications of these findings.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010.Circulation. 2014; 130: 749-756
- Lifespan perspective on congenital heart disease research: JACC state-of-the-art review.J Am Coll Cardiol. 2021; 77: 2219-2235
- American Heart Association Adult Congenital Heart Disease Committee of the Council on Clinical Cardiology and Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; and Council on Quality of Care and Outcomes Research. Diagnosis and management of noncardiac complications in adults with congenital heart disease: a scientific statement From the American Heart Association.Circulation. 2017; 136: e348-e392
- Prevalence and associated factors of renal dysfunction and proteinuria in cyanotic congenital heart disease.Pediatr Nephrol. 2018; 33: 493-501
- Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.Pediatr Nephrol. 2018; 33: 2193-2199
- Acute kidney injury in congenital heart disease.Curr Opin Cardiol. 2018; 33: 101-107
- Extra-cardiac manifestations of adult congenital heart disease.Trends Cardiovasc Med. 2016; 26: 627-636
- Practice recommendations for the monitoring of renal function in pediatric non-renal organ transplant recipients.Pediatr Transplant. 2016; 20: 352-363
- Frailty, length of stay, and mortality in kidney transplant recipients: a national registry and prospective cohort study.Ann Surg. 2017; 266: 1084-1090
- 2018 AHA/ACC guideline for the management of adults With congenital heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice guidelines.Circulation. 2019; 139: e698-e800
- The incidence of congenital heart disease.J Am Coll Cardiol. 2002; 39: 1890-1900
- Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease.Kidney Int. 2017; 92: 751-756
- Incidence of ESKD and mortality among children with congenital heart disease after cardiac surgery.Clin J Am Soc Nephrol. 2019; 14: 1450-1457
- Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease.Circulation. 2008; 117: 2320-2328
- Is it time for a multi-specialty approach to cardio-renal dysfunction in children with cyanotic congenital heart disease?.Pediatr Nephrol. 2018; 33: 359-360
- Prevalence and risk factors associated with renal dysfunction in patients with single ventricle congenital heart disease after Fontan palliation.Congenit Heart Dis. 2020; 15: 181-195
- Genetic link between renal birth defects and congenital heart disease.Nat Commun. 2016; 7: 11103
- Oxidative stress in kidney transplantation: causes, consequences, and potential treatment.Iran J Kidney Dis. 2011; 5: 357-372
- 4HNE impairs myocardial bioenergetics in congenital heart disease-induced right ventricular failure.Circulation. 2020; 142: 1667-1683
Article info
Publication history
Published online: November 06, 2022
Received in revised form:
October 6,
2022
Received:
August 3,
2022
Footnotes
Funding: none.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
