Advertisement

Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials

Published:November 14, 2022DOI:https://doi.org/10.1016/j.amjcard.2022.10.032
      Transcatheter aortic valve replacement (TAVR) has become a mainstay treatment option for most patients with severe symptomatic aortic stenosis. Although the majority of TAVR-related complications have decreased overtime, stroke rates remained relatively unchanged.
      • Mack MJ
      • Leon MB
      • Thourani VH
      • Makkar R
      • Kodali SK
      • Russo M
      • Kapadia SR
      • Malaisrie SC
      • Cohen DJ
      • Pibarot P
      • Leipsic J
      • Hahn RT
      • Blanke P
      • Williams MR
      • McCabe JM
      • Brown DL
      • Babaliaros V
      • Goldman S
      • Szeto WY
      • Genereux P
      • Pershad A
      • Pocock SJ
      • Alu MC
      • Webb JG
      • Smith CR
      PARTNER 3 Investigators
      Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients.
      ,
      • Leon MB
      • Smith CR
      • Mack MJ
      • Makkar RR
      • Svensson LG
      • Kodali SK
      • Thourani VH
      • Tuzcu EM
      • Miller DC
      • Herrmann HC
      • Doshi D
      • Cohen DJ
      • Pichard AD
      • Kapadia S
      • Dewey T
      • Babaliaros V
      • Szeto WY
      • Williams MR
      • Kereiakes D
      • Zajarias A
      • Greason KL
      • Whisenant BK
      • Hodson RW
      • Moses JW
      • Trento A
      • Brown DL
      • Fearon WF
      • Pibarot P
      • Hahn RT
      • Jaber WA
      • Anderson WN
      • Alu MC
      • Webb JG
      PARTNER 2 Investigators
      Transcatheteror surgical aortic-valve replacement in intermediate-risk patients.
      Hence, numerous efforts have been devoted to developing effective strategies to mitigate the risk of post-TAVR strokes. We performed an updated meta-analysis to assess the efficacy and safety of cerebral embolic protection (CEP) during TAVR.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Mack MJ
        • Leon MB
        • Thourani VH
        • Makkar R
        • Kodali SK
        • Russo M
        • Kapadia SR
        • Malaisrie SC
        • Cohen DJ
        • Pibarot P
        • Leipsic J
        • Hahn RT
        • Blanke P
        • Williams MR
        • McCabe JM
        • Brown DL
        • Babaliaros V
        • Goldman S
        • Szeto WY
        • Genereux P
        • Pershad A
        • Pocock SJ
        • Alu MC
        • Webb JG
        • Smith CR
        • PARTNER 3 Investigators
        Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients.
        N Engl J Med. 2019; 380: 1695-1705
        • Leon MB
        • Smith CR
        • Mack MJ
        • Makkar RR
        • Svensson LG
        • Kodali SK
        • Thourani VH
        • Tuzcu EM
        • Miller DC
        • Herrmann HC
        • Doshi D
        • Cohen DJ
        • Pichard AD
        • Kapadia S
        • Dewey T
        • Babaliaros V
        • Szeto WY
        • Williams MR
        • Kereiakes D
        • Zajarias A
        • Greason KL
        • Whisenant BK
        • Hodson RW
        • Moses JW
        • Trento A
        • Brown DL
        • Fearon WF
        • Pibarot P
        • Hahn RT
        • Jaber WA
        • Anderson WN
        • Alu MC
        • Webb JG
        • PARTNER 2 Investigators
        Transcatheteror surgical aortic-valve replacement in intermediate-risk patients.
        N Engl J Med. 2016; 374: 1609-1620
        • Kapadia SR
        • Makkar R
        • Leon M
        • Abdel-Wahab M
        • Waggoner T
        • Massberg S
        • Rottbauer W
        • Horr S
        • Sondergaard L
        • Karha J
        • Gooley R
        • Satler L
        • Stoler RC
        • Messé SR
        • Baron SJ
        • Seeger J
        • Kodali S
        • Krishnaswamy A
        • Thourani VH
        • Harrington K
        • Pocock S
        • Modolo R
        • Allocco DJ
        • Meredith IT
        • Linke A
        • PROTECTED TAVR Investigators
        Cerebral embolic protection during transcatheter aortic-valve replacement.
        N Engl J Med. 2022; 387: 1253-1263
      1. NHS Health Research Authority. BHS PROTECT-TAVI. Available at: https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/bhf-protect-tavi/. Accessed on September 19, 2022.