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Trends and Outcomes of Transcatheter Aortic Valve Implantation in Hypertrophic Cardiomyopathy

Published:July 16, 2022DOI:https://doi.org/10.1016/j.amjcard.2022.06.024
Trends and Outcomes of Transcatheter Aortic Valve Implantation in Hypertrophic Cardiomyopathy
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      The landmark clinical trials on the utility of transcatheter aortic valve implantation (TAVI) excluded patients with hypertrophic cardiomyopathy (HCM) and concomitant severe aortic stenosis.
      • Leon MB
      • Smith CR
      • Mack M
      • Miller DC
      • Moses JW
      • Svensson LG
      • Tuzcu EM
      • Webb JG
      • Fontana GP
      • Makkar RR
      • Brown DL
      • Block PC
      • Guyton RA
      • Pichard AD
      • Bavaria JE
      • Herrmann HC
      • Douglas PS
      • Petersen JL
      • Akin JJ
      • Anderson WN
      • Wang D
      • Pocock S
      PARTNER Trial Investigators
      Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery.
      N Engl J Med. 2010; 363: 1597-1607
      TAVI in HCM presents unique technical or physiologic challenges called “suicide left ventricle,” that is, sudden reduction in afterload after TAVI exacerbates subvalvular obstruction, which leads to hemodynamic collapse.
      • Nguyen V
      • Iskandar M.
      Suicide left ventricle: the importance of continuing beta blockers in cardiogenic shock post-TAVR.
      J Card Fail. 2018; 24: S85-S86
      Despite this, TAVI has increasingly been used in patients with HCM with no large-scale data on its safety.
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      References

        • Leon MB
        • Smith CR
        • Mack M
        • Miller DC
        • Moses JW
        • Svensson LG
        • Tuzcu EM
        • Webb JG
        • Fontana GP
        • Makkar RR
        • Brown DL
        • Block PC
        • Guyton RA
        • Pichard AD
        • Bavaria JE
        • Herrmann HC
        • Douglas PS
        • Petersen JL
        • Akin JJ
        • Anderson WN
        • Wang D
        • Pocock S
        • PARTNER Trial Investigators
        Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery.
        N Engl J Med. 2010; 363: 1597-1607
        View in Article
        • Nguyen V
        • Iskandar M.
        Suicide left ventricle: the importance of continuing beta blockers in cardiogenic shock post-TAVR.
        J Card Fail. 2018; 24: S85-S86
        View in Article
        • Bandyopadhyay D
        • Chakraborty S
        • Amgai B
        • Kapadia SR
        • Braunwald E
        • Naidu SS
        • Kalra A.
        Association of hypertrophic obstructive cardiomyopathy with outcomes following transcatheter aortic valve replacement.
        JAMA Netw Open. 2020; 3e1921669
        View in Article

      Article Info

      Publication History

      Published online: July 16, 2022
      Received: May 23, 2022

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.amjcard.2022.06.024

      Copyright

      © 2022 Elsevier Inc. All rights reserved.

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