Spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) are
pathologies that appear to be closely related. This study compares the characteristics
of the FMD population to the non-FMD population in a SCAD cohort. It thus assesses
the involvement of the FMD phenotype in a SCAD population. From the data of the French
DISCO registry, we included patients with a diagnosis of SCAD and in whom a search
for FMD was performed. We collected the following characteristics of this population:
the clinical and angiographic presentation, the data concerning the management, and
the events occurring during the follow-up. In the 373 SCADs confirmed in the DISCO
registry, we obtained imaging data for 340 of them. FMD was found in 45% of cases.
The mean age was higher in the FMD group, 53.2 ± 8.8 years, versus 50.1 ± 11 years
in the non-FMD group. High blood pressure and postmenopausal status were significantly
higher in the FMD group. Clinical presentation, angiographic data, and management
were comparable. The major adverse cardiac event rate and recurrence rate were not
different between the 2 groups after 1 year of follow-up. In conclusion, we confirmed
a 45% prevalence of FMD in the SCAD population. The median age was higher in the FMD
group, suggesting that FMD may develop over time. The rate of major adverse cardiac
events and recurrence were similar in the FMD group versus the non-FMD group after
1 year of follow-up.
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Article info
Publication history
Published online: May 10, 2022
Received in revised form:
March 22,
2022
Received:
December 28,
2021
Identification
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