Long-term endurance exercise training has been associated with increased coronary
artery calcification (CAC). We evaluated 2 life-long marathon runners with CAC scores
>900 Agatston units (AgU). Both did not have risk factors for coronary artery disease
and had serum low-density lipoprotein–cholesterol (LDL-C) levels habitually <129 mg/dl.
Their serum calcium and parathyroid hormone (PTH) levels were diagnostic of primary
hyperparathyroidism (PHPT). Both patients were referred to endocrinologists and underwent
parathyroidectomy. Our cases illustrate the possible association between hyperparathyroidism
and elevated CAC.
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References
- Exercise and coronary atherosclerosis: observations, explanations, relevance, and clinical management.Circulation. 2020; 141: 1338-1350
- Parathyroid hormone and physical exercise: a brief review.J Sports Sci Med. 2006; 5: 367-374
- Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts.Arterioscler Thromb Vasc Biol. 2014; 34: 1567-1573
- Diagnosis and management of primary hyperparathyroidism.JAMA. 2020; 323: 1186-1187
Article Info
Publication History
Published online: March 28, 2022
Received in revised form:
February 28,
2022
Received:
January 30,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
