Hyperparathyroidism Possibly Causing Increased Coronary Artery Calcification

      Long-term endurance exercise training has been associated with increased coronary artery calcification (CAC). We evaluated 2 life-long marathon runners with CAC scores >900 Agatston units (AgU). Both did not have risk factors for coronary artery disease and had serum low-density lipoprotein–cholesterol (LDL-C) levels habitually <129 mg/dl. Their serum calcium and parathyroid hormone (PTH) levels were diagnostic of primary hyperparathyroidism (PHPT). Both patients were referred to endocrinologists and underwent parathyroidectomy. Our cases illustrate the possible association between hyperparathyroidism and elevated CAC.
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        • Aengevaeren VL
        • Mosterd A
        • Sharma S
        • Prakken NHJ
        • Möhlenkamp S
        • Thompson PD
        • Velthuis BK
        • Eijsvogels TMH.
        Exercise and coronary atherosclerosis: observations, explanations, relevance, and clinical management.
        Circulation. 2020; 141: 1338-1350
        • Bouassida A
        • Latiri I
        • Bouassida S
        • Zalleg D
        • Zaouali M
        • Feki Y
        • Gharbi N
        • Zbidi A
        • Tabka Z.
        Parathyroid hormone and physical exercise: a brief review.
        J Sports Sci Med. 2006; 5: 367-374
        • Hagström E
        • Michaëlsson K
        • Melhus H
        • Hansen T
        • Ahlström H
        • Johansson L
        • Ingelsson E
        • Sundström J
        • Lind L
        • Arnlöv J.
        Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts.
        Arterioscler Thromb Vasc Biol. 2014; 34: 1567-1573
        • Zhu CY
        • Sturgeon C
        • Yeh MW.
        Diagnosis and management of primary hyperparathyroidism.
        JAMA. 2020; 323: 1186-1187