Percutaneous left atrial appendage closure (LAAC) with the Watchman device (Boston
Scientific, Marlborough, MA) is indicated for reduction of thromboembolic risk in
patients with non-valvular atrial fibrillation who are poor candidates for long-term
oral anticoagulation. The procedure is performed via femoral venous access using a
14 F sheath. Data from the pivotal randomized controlled trials and real-world clinical
practice have shown that major bleeding in the procedural setting remains one of the
most common complications of LAAC (1.5% to 3.5%).
1
,2
To date, scarce data exist on the impact of major bleeding on outcomes after LAAC.
Therefore, we aimed to investigate the association of major bleeding following LAAC
on outcomes using a contemporary nationwide database.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- PREVAIL and PROTECT AF investigators. 5-year outcomes after left atrial appendage closure: from the PREVAIL and PROTECT AF trials.J Am Coll Cardiol. 2017; 70: 2964-2975
- The NCDR left atrial appendage occlusion registry.J Am Coll Cardiol. 2020; 75: 1503-1518
Anon. NRD Overview. Available at: https://www.hcup-us.ahrq.gov/nrdoverview.jsp. Accessed March 20, 2021.
- Bleeding outcomes after left atrial appendage closure compared with long-term warfarin: a pooled, patient-level analysis of the WATCHMAN randomized trial experience.JACC Cardiovasc Interv. 2015; 8: 1925-1932
- Incidence, predictors, and prognostic value of acute kidney injury among patients undergoing left atrial appendage closure.JACC Cardiovasc Interv. 2018; 11: 1074-1083
Article info
Publication history
Published online: May 16, 2021
Received:
March 31,
2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
