- Reilev M
- Kristensen KB
- Pottegard A
- Lund LC
- Hallas J
- Ernst MT
- Christiansen CF
- Sorensen HT
- Johansen NB
- Brun NC
- Voldstedlund M
- Stovring H
- Thomsen MK
- Christensen S
- Gubbels S
- Krause TG
- Molbak K
- Thomsen RW.
- Rodilla E
- Saura A
- Jimenez I
- Mendizabal A
- Pineda-Cantero A
- Lorenzo-Hernandez E
- Fidalgo-Montero MDP
- Lopez-Cuervo JF
- Gil-Sanchez R
- Rabadan-Pejenaute E
- Abella-Vazquez L
- Giner-Galvan V
- Solis-Marquinez MN
- Boixeda R
- Pena-Fernandez A
- Carrasco-Sanchez FJ
- Gonzalez-Moraleja J
- Torres-Pena JD
- Guisado-Espartero ME
- Escobar-Sevilla J
- Guzman-Garcia M
- Martin-Escalante MD
- Martinez-Gonzalez AL
- Casas-Rojo JM
- Gomez-Huelgas R.
- Izurieta HS
- Graham DJ
- Jiao Y
- Hu M
- Lu Y
- Wu Y
- Chillarige Y
- Wernecke M
- Menis M
- Pratt D
- Kelman J
- Forshee R.
- Lala A
- Johnson KW
- Januzzi JL
- Russak AJ
- Paranjpe I
- Richter F
- Zhao S
- Somani S
- Van Vleck T
- Vaid A
- Chaudhry F
- De Freitas JK
- Fayad ZA
- Pinney SP
- Levin M
- Charney A
- Bagiella E
- Narula J
- Glicksberg BS
- Nadkarni G
- Mancini DM
- Fuster V
- Mount Sinai CIC
- Liang X
- Xu J
- Xiao W
- Shi L
- Yang H.
- Xiao W
- Xu J
- Liang X
- Shi L
- Zhang P
- Wang Y
- Yang H.
- Yang H
- Xu J
- Liang X
- Shi L
- Wang Y.
- Reilev M
- Kristensen KB
- Pottegard A
- Lund LC
- Hallas J
- Ernst MT
- Christiansen CF
- Sorensen HT
- Johansen NB
- Brun NC
- Voldstedlund M
- Stovring H
- Thomsen MK
- Christensen S
- Gubbels S
- Krause TG
- Molbak K
- Thomsen RW.
- Rodilla E
- Saura A
- Jimenez I
- Mendizabal A
- Pineda-Cantero A
- Lorenzo-Hernandez E
- Fidalgo-Montero MDP
- Lopez-Cuervo JF
- Gil-Sanchez R
- Rabadan-Pejenaute E
- Abella-Vazquez L
- Giner-Galvan V
- Solis-Marquinez MN
- Boixeda R
- Pena-Fernandez A
- Carrasco-Sanchez FJ
- Gonzalez-Moraleja J
- Torres-Pena JD
- Guisado-Espartero ME
- Escobar-Sevilla J
- Guzman-Garcia M
- Martin-Escalante MD
- Martinez-Gonzalez AL
- Casas-Rojo JM
- Gomez-Huelgas R.
- Izurieta HS
- Graham DJ
- Jiao Y
- Hu M
- Lu Y
- Wu Y
- Chillarige Y
- Wernecke M
- Menis M
- Pratt D
- Kelman J
- Forshee R.
- Lala A
- Johnson KW
- Januzzi JL
- Russak AJ
- Paranjpe I
- Richter F
- Zhao S
- Somani S
- Van Vleck T
- Vaid A
- Chaudhry F
- De Freitas JK
- Fayad ZA
- Pinney SP
- Levin M
- Charney A
- Bagiella E
- Narula J
- Glicksberg BS
- Nadkarni G
- Mancini DM
- Fuster V
- Mount Sinai CIC
- Hippisley-Cox J
- Tan PS
- Coupland C.
- Peterson E
- Lo KB
- DeJoy R
- Salacup G
- Pelayo J
- Bhargav R
- Gul F
- Albano J
- Azmaiparashvili Z
- Amanullah A
- Patarroyo-Aponte G.
- Perez-Guzman PN
- Daunt A
- Mukherjee S
- Crook P
- Forlano R
- Kont MD
- Lochen A
- Vollmer M
- Middleton P
- Judge R
- Harlow C
- Soubieres A
- Cooke G
- White PJ
- Hallett TB
- Aylin P
- Ferguson N
- Hauck K
- Thursz MR
- Nayagam S.
- Elias P
- Poterucha TJ
- Jain SS
- Sayer G
- Raikhelkar J
- Fried J
- Clerkin K
- Griffin J
- DeFilippis EM
- Gupta A
- Lawlor M
- Madhavan M
- Rosenblum H
- Roth ZB
- Natarajan K
- Hripcsak G
- Perotte A
- Wan EY
- Saluja A
- Dizon J
- Ehlert F
- Morrow JP
- Yarmohammadi H
- Kumaraiah D
- Redfors B
- Gavin N
- Kirtane A
- Rabbani L
- Burkhoff D
- Moses J
- Schwartz A
- Leon M
- Uriel N.
- Clift AK
- Coupland CAC
- Keogh RH
- Diaz-Ordaz K
- Williamson E
- Harrison EM
- Hayward A
- Hemingway H
- Horby P
- Mehta N
- Benger J
- Khunti K
- Spiegelhalter D
- Sheikh A
- Valabhji J
- Lyons RA
- Robson J
- Semple MG
- Kee F
- Johnson P
- Jebb S
- Williams T
- Hippisley-Cox J.
- Alvarez-Garcia J
- Lee S
- Gupta A
- Cagliostro M
- Joshi AA
- Rivas-Lasarte M
- Contreras J
- Mitter SS
- LaRocca G
- Tlachi P
- Brunjes D
- Glicksberg BS
- Levin MA
- Nadkarni G
- Fayad Z
- Fuster V
- Mancini D
- Lala A.
- Tomasoni D
- Inciardi RM
- Lombardi CM
- Tedino C
- Agostoni P
- Ameri P
- Barbieri L
- Bellasi A
- Camporotondo R
- Canale C
- Carubelli V
- Carugo S
- Catagnano F
- Dalla Vecchia LA
- Danzi GB
- Di Pasquale M
- Gaudenzi M
- Giovinazzo S
- Gnecchi M
- Iorio A
- La Rovere MT
- Leonardi S
- Maccagni G
- Mapelli M
- Margonato D
- Merlo M
- Monzo L
- Mortara A
- Nuzzi V
- Piepoli M
- Porto I
- Pozzi A
- Sarullo F
- Sinagra G
- Volterrani M
- Zaccone G
- Guazzi M
- Senni M
- Metra M
- Polverino F
- Stern DA
- Ruocco G
- Balestro E
- Bassetti M
- Candelli M
- Cirillo B
- Contoli M
- Corsico A
- D'Amico F
- D'Elia E
- Falco G
- Gasparini S
- Guerra S
- Harari S
- Kraft M
- Mennella L
- Papi A
- Parrella R
- Pelosi P
- Poletti V
- Polverino M
- Tana C
- Terribile R
- Woods JC
- Di Marco F
- Martinez FD
- Loffi M
- Piccolo R
- Regazzoni V
- Di Tano G
- Moschini L
- Robba D
- Quinzani F
- Esposito G
- Franzone A
- Danzi GB.
- Rossi L
- Malagoli A
- Biagi A
- Zanni A
- Sticozzi C
- Comastri G
- Pannone L
- Gandolfi S
- Vergara P
- Villani GQ.
- Lano G
- Braconnier A
- Bataille S
- Cavaille G
- Moussi-Frances J
- Gondouin B
- Bindi P
- Nakhla M
- Mansour J
- Halin P
- Levy B
- Canivet E
- Gaha K
- Kazes I
- Noel N
- Wynckel A
- Debrumetz A
- Jourde-Chiche N
- Moal V
- Vial R
- Scarfogliere V
- Bobot M
- Gully M
- Legris T
- Pelletier M
- Sallee M
- Burtey S
- Brunet P
- Robert T
- Rieu P.
Author | Country | Cases | Male (%) | Age§ | Study design | Adjusted-effect size (95% CI) |
---|---|---|---|---|---|---|
Lala A | USA | 2736 | 59.6% | 66.4 | Retrospective study | OR: 1.08 (0.81-1.44) |
Atkins JL | UK | 507 | 61.3% | 74.3±4.5 | UK biobank cohort | OR: 1.63 (0.98-2.71) |
van Gerwen M | USA | 3703 | 55.3% | 56.8±18.2 | Retrospective study | OR: 1.19 (0.87-1.62) |
Hippisley-Cox J | UK | 19486 | 48.1% | 62.18±20.84 | Prospective study | HR: 0.87 (0.55-1.39) |
Peterson E | USA | 355 | 51% | 66.21±14.21 | Retrospective study | OR: 0.475 (0.190-1.188) |
Perez-Guzman PN | UK | 614 | 62.2% | 69 (25) | Retrospective study | OR: 1.25 (0.73-2.13) |
Reilev M | Denmark | 11122 | 42.2% | 48 (33-62) | Population-based study | OR: 1.6 (1.2-2.0) |
Rodilla E | Spain | 12226 | 57.4% | 67.5±16.1 | Retrospective study | OR: 1.2 (1.01-1.33) |
Elias P | USA | 1258 | 54% | 61.6±18.4 | Retrospective study | OR: 2.54 (1.05-6.2) |
Peltzer B | USA | 1053 | 62.3% | 62±17 | Retrospective study | OR: 2.16 (1.33-3.52) |
Rodriguez-Molinero A | Spain | 418 | 56.9% | 65.4±16.6 | Observational cohort study | OR: 1.86 (0.86-4.02) |
Clift AK | UK | 10776 | 55.3% | 69.63±17.91 | Observational cohort study | HR: 1.18 (1.04-1.34) |
HR: 1.11 (1.00-1.24) | ||||||
Alvarez-Garcia J | USA | 6349 | 55.1% | 63.5±18 | Retrospective study | HR: 0.91 (0.63-1.31) |
Tang O | USA | 752 | 39.9% | 71.16±51.68 | Retrospective study | HR: 0.86 (0.57-1.30) |
Shah C | USA | 487 | 56.1% | 68.42±16.70 | Retrospective study | OR: 0.91 (0.50-1.65) |
Tomasoni D | Italy | 692 | 69.5% | 67.4±13.2 | Retrospective study | HR: 1.27 (0.73-2.23) |
Polverino F | USA | 3179 | 68.3% | 69.0 (57-78) | Retrospective study | OR: 0.97 (0.69-1.36) |
Loffi M | Italy | 1252 | 63.7% | 64.7±15.5 | Retrospective study | HR: 1.09 (0.75-1.58) |
Canevelli M | Italy | 2621 | 67.6% | 78.16±10.51 | Retrospective study | OR: 0.99 (0.72-1.37) |
Rossi L | Italy | 590 | 66.1% | 76.2 (68.2-82.6) | Retrospective study | HR: 1.390 (0.925-1.885) |
Gue YX | UK | 486 | 38.7% | 73.42±15.97 | Retrospective study | OR: 0.49 (0.35-1.58) |
Izurieta HS | USA | 27961 | 48.8% | 79.07±10.15 | Retrospective study | OR: 0.97 (0.92-1.01) |
Lano G | France | 122 | 65% | 73.5 (64.2-81.2) | Observational cohort study | OR: 1.838 (0.751-4.481) |

Author Contributions
Conflicts of Interest Statement
Acknowledgment
REFERENCES
- Outcomes and mortality associated with atrial arrhythmias among patients hospitalized with COVID-19.J Cardiovasc Electrophysiol. 2020; 31: 3077-3085
- Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.Int J Epidemiol. 2020; 49: 1468-1481
- Association of hypertension with all-cause mortality among hospitalized patients with COVID-19.J Clin Med. 2020; 9https://doi.org/10.3390/jcm9103136
- Natural history of COVID-19: risk factors for hospitalizations and deaths among >26 million U.S. Medicare beneficiaries.J Infect Dis. 2020; https://doi.org/10.1093/infdis/jiaa767
- Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection.J Am Coll Cardiol. 2020; 76: 533-546
- Risk factors and outcomes of COVID-19 in New York City; a retrospective cohort study.J Med Virol. 2021; 93: 907-915
- Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: a meta-analysis with 55 studies and 10014 cases.Heliyon. 2020; 6: e05684
- Association of sex, age, and comorbidities with mortality in COVID-19 Patients: a systematic review and meta-analysis.Intervirology. 2020; : 1-12
- The association of hypertension with the severity and mortality of COVID-19 patients: evidence based on adjusted effect estimates.J Infect. 2020; 81: e44-e47
- The association of diabetes with COVID-19 disease severity: evidence from adjusted effect estimates.Hormones. 2020; https://doi.org/10.1007/s42000-020-00259-x
- Relationship between chronic kidney disease and adverse outcomes of coronavirus disease 2019: a meta-analysis based on adjusted risk estimates.Int Urol Nephrol. 2021; https://doi.org/10.1007/s11255-020-02748-9
- Autoimmune diseases are independently associated with COVID-19 severity: evidence based on adjusted effect estimates.J Infect. 2020; https://doi.org/10.1016/j.jinf.2020.12.025
- Is chronic obstructive pulmonary disease an independent predictor for adverse outcomes in coronavirus disease 2019 patients?.Eur Rev Med Pharmacol Sci. 2020; 24: 11421-11427
- Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort.J Gerontol A Biol Sci Med Sci. 2020; 75: 2224-2230
- Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people.Heart. 2020; https://doi.org/10.1136/heartjnl-2020-318312
- The relationship between coronary artery disease and clinical outcomes in COVID-19: a single-center retrospective analysis.Coron Artery Dis. 2020; https://doi.org/10.1097/MCA.0000000000000934
- Clinical characteristics and predictors of outcomes of hospitalized patients with COVID-19 in a multi-ethnic London NHS Trust: a retrospective cohort study.Clin Infect Dis. 2020; https://doi.org/10.1093/cid/ciaa1091
- The prognostic value of electrocardiogram at presentation to emergency department in patients with COVID-19.Mayo Clin Proc. 2020; 95: 2099-2109
- Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients.PloS one. 2020; 15e0239571
- Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.Bmj. 2020; 371: m3731
- Prognostic impact of prior heart failure in patients hospitalized with COVID-19.J Am Coll Cardiol. 2020; 76: 2334-2348
- Outcomes of nursing home COVID-19 patients by initial symptoms and comorbidity: results of universal testing of 1970 residents.J Am Med Dir Assoc. 2020; 21 (e1761): 1767-1773
- Factors associated with increased mortality in hospitalized COVID-19 patients.Ann Med Surg (Lond). 2020; 60: 308-313
- Impact of heart failure on the clinical course and outcomes of patients hospitalized for COVID-19. Results of the Cardio-COVID-Italy multicentre study.Eur J Heart Fail. 2020; https://doi.org/10.1002/ejhf.2052
- Comorbidities, cardiovascular therapies, and COVID-19 mortality: a nationwide, Italian Observational Study (ItaliCO).Front Cardiovasc Med. 2020; 7585866
- Coronary artery disease in patients hospitalised with Coronavirus disease 2019 (COVID-19) infection.Open heart. 2020; 7https://doi.org/10.1136/openhrt-2020-001428
- Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy.Alzheimers Dement (Amst). 2020; 12: e12114
- Renin-angiotensin system inhibitors and mortality in patients with COVID-19.Infection. 2020; https://doi.org/10.1007/s15010-020-01550-0
- Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19.Sci Rep. 2020; 10: 21379
- Risk factors for severity of COVID-19 in chronic dialysis patients from a multicentre French cohort.Clin Kidney J. 2020; 13: 878-888
Article Info
Publication History
Footnotes
This study was supported by grants from National Natural Science Foundation of China (grant number 81973105 ), Key Scientific Research Project of Henan Institution of Higher Education (grant number 21A330008 ) and Joint Construction Project of Henan Medical Science and Technology Research Plan (grant number LHGJ20190679 ). The funders have no role in the data collection, data analysis, preparation of manuscript and decision to submission.