Highlights
- •Elevated CRP levels were associated with angina pectoris.
- •Patients with angina pectoris syndromes can probably be prediagnosed by their levels of CRP.
- •CRP levels may be a risk factor of major adverse cardiac event.
Associations between elevated C-reactive protein (CRP) levels and the angina pectoris
risk have been reported for many years, but the results remain controversial. To address
this issue, a meta-analysis was therefore conducted. Eligible studies were identified
by searching PubMed, EMBASE, Cochrane library, and web of science up to January 2019.
Altogether, 10 prospective cohort studies and 11 case-control studies were included,
and they were published from 1997 to 2013 and summed up to 18,316 samples totally.
The pooled mean difference of CRP levels was 4.44 (95% confidence interval 2.71 to
6.17) between angina patients and healthy controls. The combined odds ratio of CRP
for major adverse cardiac events in angina patients was 1.67 (95% CI 1.23 to 2.26).
In conclusion, the meta-analysis indicated that elevated CRP levels were associated
with angina pectoris, especially unstable angina pectoris, and were probably a risk
factor of major adverse cardiac events.
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Article info
Publication history
Published online: January 07, 2020
Received in revised form:
December 29,
2019
Received:
October 30,
2019
Footnotes
There were no sources of funding for this research.
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