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Deterioration in Left Ventricular Systolic Function in Heart Failure With Preserved and Midrange Ejection Fraction: Don't Miss Coronary Artery Disease

Published:September 18, 2019DOI:https://doi.org/10.1016/j.amjcard.2019.09.001
      I read with great interest the article by Kalogeropoulos et al which reports outcome in patients with heart failure and preserved ejection fraction according to changes in left ventricular ejection fraction during follow-up.
      • Kalogeropoulos AP
      • Kim S
      • Rawal S
      • Jadonath A
      • Tangutoori R
      • Georgiopoulou V
      Serial changes in left ventricular ejection fraction and outcomes in outpatients with heart failure and preserved ejection fraction.
      The authors reported that deterioration in left ventricular systolic function is not uncommon, is related to uncontrolled hypertension, and is linked to adverse outcome. Accordingly, it is of crucial importance to identify other potential factors that contribute to decline in left ventricular ejection fraction in this setting, with the aim to implement targeted therapeutic interventions.
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