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Lipid Profile and New-Onset Atrial Fibrillation in Patients With Acute ST-Segment Elevation Myocardial Infarction (An Observational Study in Southwest of China)

      In acute ST-segment elevation myocardial infarction (ASTEMI), new-onset atrial fibrillation (NOAF) was not only associated with worse short-term outcomes but also with higher long-term mortality. This study aimed to evaluate the effect of dyslipidemia on the incidence of NOAF. Among the 985 patients (2014 to 2017) with ASTEMI consecutively enrolled and followed-up for 31 months in this study, 81 patients (8.2%) developed NOAF during hospitalization. Fasting levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured using standard procedures. The study population was categorized into 3 groups based on tertiles of lipid profile. Multivariate regression analysis was adjusted for baseline characteristics, laboratory values, angiography findings, and medication. Inverse associations of TC (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.32 to 0.90) and LDL-C (hazard ratio 0.56, 95% confidence interval 0.31 to 1.00) with NOAF was observed in this study. In contrast, the levels of TG and HDL-C were not associated with NOAF in patients with ASTEMI. Moreover, the all-cause mortality in the NOAF group (19.8%) was apparently higher than that in sinus rhythm goup (6.1%) after a long term follow-up. In conclusion, plasma LDL-C and TC concentrations but neither TG nor HDL-C were inversely correlated to NOAF during hospitalization, which indicated a bad prognosis even after discharge.
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      References

        • Lopez FL
        • Agarwal SK
        • Maclehose RF
        • Soliman EZ
        • Sharrett AR
        • Huxley RR
        • Konety S
        • Ballantyne CM
        • Alonso A
        Blood lipid levels, lipid-lowering medications, and the incidence of atrial fibrillation: the atherosclerosis risk in communities study.
        Circ Arrhythm Electrophysiol. 2012; 5: 155-162
        • Li X
        • Gao L
        • Wang Z
        • Guan B
        • Guan X
        • Wang B
        • Han X
        • Xiao X
        • Waleed KB
        • Chandran C
        • Wu S
        • Xia Y
        Lipid profile and incidence of atrial fibrillation: a prospective cohort study in China.
        Clin Cardiol. 2018; 41: 314-320
        • Alonso A
        • Yin X
        • Roetker NS
        • Magnani JW
        • Kronmal RA
        • Ellinor PT
        • Chen LY
        • Lubitz SA
        • McClelland RL
        • McManus DD
        • Soliman EZ
        • Huxley RR
        • Nazarian S
        • Szklo M
        • Heckbert SR
        • Benjamin EJ
        Blood lipids and the incidence of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis and the Framingham Heart Study.
        J Am Heart Assoc. 2014; 3e001211
      1. [Guideline on the diagnosis and therapy of ST-segment elevation myocardial infarction].
        Zhonghua xin xue guan bing za zhi. 2015; 43: 380-393
        • Ding X
        • Zheng X
        • Xing A
        • Wang D
        • Qi S
        • Wu Y
        • Li H
        • Wu S
        • Hong J
        High risk factors of atrial fibrillation in type 2 diabetes: results from the Chinese Kailuan study.
        QJM. 2015; 108: 885-890
        • Watanabe H
        • Tanabe N
        • Yagihara N
        • Watanabe T
        • Aizawa Y
        • Kodama M
        Association between lipid profile and risk of atrial fibrillation.
        Circulation. 2011; 75: 2767-2774
        • Iguchi Y
        • Kimura K
        • Shibazaki K
        • Aoki J
        • Kobayashi K
        • Sakai K
        • Sakamoto Y
        Annual incidence of atrial fibrillation and related factors in adults.
        Am J Cardiol. 2010; 106: 1129-1233
        • Magnussen C
        • Niiranen TJ
        • Ojeda FM
        • Gianfagna F
        • Blankenberg S
        • Njolstad I
        • Vartiainen E
        • Sans S
        • Pasterkamp G
        • Hughes M
        • Costanzo S
        • Donati MB
        • Jousilahti P
        • Linneberg A
        • Palosaari T
        • de Gaetano G
        • Bobak M
        • den Ruijter HM
        • Mathiesen E
        • Jorgensen T
        • Soderberg S
        • Kuulasmaa K
        • Zeller T
        • Iacoviello L
        • Salomaa V
        • Schnabel RB
        • BiomarCa REC
        Sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts: results from the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe).
        Circulation. 2017; 136: 1588-1597
        • Mora S
        • Akinkuolie AO
        • Sandhu RK
        • Conen D
        • Albert CM
        Paradoxical association of lipoprotein measures with incident atrial fibrillation.
        Circ Arrhythm Electrophysiol. 2014; 7: 612-619
        • Mourtzinis G
        • Kahan T
        • Bengtsson Bostrom K
        • Schioler L
        • Cedstrand Wallin L
        • Hjerpe P
        • Hasselstrom J
        • Manhem K
        Relation between lipid profile and new-onset atrial fibrillation in patients with systemic hypertension (From the Swedish Primary Care Cardiovascular Database [SPCCD]).
        Am J Cardiol. 2018; 122: 102-107
        • Liu C
        • Geng J
        • Ye X
        • Yuan X
        • Li A
        • Zhang Z
        • Xu B
        • Wang Y
        Change in lipid profile and risk of new-onset atrial fibrillation in patients with chronic heart failure: a 3-year follow-up observational study in a large Chinese hospital.
        Medicine (Baltimore). 2018; 97: e12485
        • Psaty BM
        • Manolio TA
        • Kuller LH
        • Kronmal RA
        • Cushman M
        • Fried LP
        • White R
        • Furberg CD
        • Rautaharju PM
        Incidence of and risk factors for atrial fibrillation in older adults.
        Circulation. 1997; 96: 2455-2461
        • Bikou O
        • Kho C
        • Ishikawa K
        Atrial stretch and arrhythmia after myocardial infarction.
        Aging. 2018; 11: 11-12
        • Gal P
        • Parlak E
        • Schellings DA
        • Beukema R
        • ten Berg J
        • Adiyaman A
        • van 't Hof AW
        • Elvan A
        Association of serial high sensitivity troponin T with onset of atrial fibrillation in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.
        Eur Heart J. 2016; 5: 33-42
        • Rahman F
        • Kwan GF
        • Benjamin EJ
        Global epidemiology of atrial fibrillation.
        Nat Rev Cardiol. 2014; 11: 639-654
        • Ma W
        • Liang Y
        • Zhu J
        • Yang Y
        • Tan H
        • Yu L
        • Gao X
        • Feng G
        • Li J
        Serum potassium levels and short-term outcomes in patients with ST-segment elevation myocardial infarction.
        Angiology. 2016; 67: 729-736
        • da Silva RM
        Influence of Inflammation and Atherosclerosis in Atrial Fibrillation.
        Curr Atheroscler Rep. 2017; 19: 2
        • Kim TH
        • Yang PS
        • Yu HT
        • Jang E
        • Shin H
        • Kim HY
        • Uhm JS
        • Kim JY
        • Sung JH
        • Pak HN
        • Lee MH
        • Joung B
        • Lip GYH
        Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population.
        Eur Heart J. 2019; 40: 809-819
        • Serban RC
        • Sus I
        • Lakatos EK
        • Demjen Z
        • Ceamburu A
        • Fisca PC
        • Somkereki C
        • Hadadi L
        • Scridon A
        Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
        Acta Cardiol. 2019; : 1-8
        • Ren Y
        • Zeng RX
        • Li JJ
        • Guo LH
        • He DY
        • Li Y
        • Liao PD
        • Zhang MZ
        Relation of C-reactive protein and new-onset atrial fibrillation in patients with acute myocardial infarction: A systematic review and meta-analysis.
        Int J Cardiol. 2015; 190: 268-270
        • Heusch G
        • Gersh BJ
        The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge.
        Eur Heart J. 2017; 38: 774-784
        • Maguy A
        • Hebert TE
        • Nattel S
        Involvement of lipid rafts and caveolae in cardiac ion channel function.
        Cardiovasc Res. 2006; 69: 798-807
        • Dart C
        Lipid microdomains and the regulation of ion channel function.
        J Physiol. 2010; 588: 3169-3178
        • Epshteina Y
        • Chopraa AP
        • Rosenhouse-Dantskera A
        Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol.
        Proc Natl Acad Sci USA. 2009; 106: 8055-8060
        • Balsea E
        • El-Haoua S
        • Dillaniana G
        • Dauphinc Aurélien
        Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes.
        Proc Natl Acad Sci U S A. 2009; 106: 14681-14686
        • Hissa B
        • Oakes PW
        • Pontes B
        • Ramirez-San Juan G
        • Gardel ML
        Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes.
        Sci Rep. 2017; 7: 43764
        • Denham NC
        • Pearman CM
        • Caldwell JL
        • Madders GWP
        • Eisner DA
        • Trafford AW
        • Dibb KM
        Calcium in the pathophysiology of atrial fibrillation and heart failure.
        Front Physiol. 2018; 9: 1380