In acute ST-segment elevation myocardial infarction (ASTEMI), new-onset atrial fibrillation
(NOAF) was not only associated with worse short-term outcomes but also with higher
long-term mortality. This study aimed to evaluate the effect of dyslipidemia on the
incidence of NOAF. Among the 985 patients (2014 to 2017) with ASTEMI consecutively
enrolled and followed-up for 31 months in this study, 81 patients (8.2%) developed
NOAF during hospitalization. Fasting levels of total cholesterol (TC), triglycerides
(TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol
(HDL-C) were measured using standard procedures. The study population was categorized
into 3 groups based on tertiles of lipid profile. Multivariate regression analysis
was adjusted for baseline characteristics, laboratory values, angiography findings,
and medication. Inverse associations of TC (hazard ratio [HR] 0.54, 95% confidence
interval [CI] 0.32 to 0.90) and LDL-C (hazard ratio 0.56, 95% confidence interval
0.31 to 1.00) with NOAF was observed in this study. In contrast, the levels of TG
and HDL-C were not associated with NOAF in patients with ASTEMI. Moreover, the all-cause
mortality in the NOAF group (19.8%) was apparently higher than that in sinus rhythm
goup (6.1%) after a long term follow-up. In conclusion, plasma LDL-C and TC concentrations
but neither TG nor HDL-C were inversely correlated to NOAF during hospitalization,
which indicated a bad prognosis even after discharge.
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Article info
Publication history
Published online: August 23, 2019
Received in revised form:
July 30,
2019
Received:
May 26,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
