Some previous literature indicated an association between cardiovascular diseases
and erectile dysfunction (ED). This case-control study purposed to evaluate the association
between prior mitral valve prolapse (MVP) and ED using data from the Taiwan National
Health Insurance Research Dataset. In this study, 48,755 patients with ED were identified
as cases, and 195,020 propensity score-matched patients without ED were selected as
controls. Conditional logistic regressions were conducted to evaluate the odds ratios
(ORs) for previous MVP between cases and the matched controls. In all sampled patients,
4,565 (1.87%) patients had MVP before the index date. MVP was found in 1,304 (2.67%)
cases and in 3,261 (1.67%) matched controls. Patients with ED had a significantly
higher occurrence of MVP than the controls. In addition, after propensity score matching,
a conditional logistic regression analysis showed that the OR of previous MVP for
patients with ED was 1.63 (95% confidence interval [CI] 1.52 to 1.74) compared to
the matched controls. The ORs of previous MVP for patients with ED aged ≤65 years
and those >65 years were 1.68 (95% CI 1.56 to 1.81) and 1.49 (95% CI 1.30 to 1.70),
respectively, compared with the matched controls. We found that patients with erectile
dysfunction had significantly higher odds of previous MVP compared with matched control
subjects without ED regardless of the age group.
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References
- Erectile dysfunction.Intern Med J. 2014; 44: 18-26
- Erectile dysfunction.BMJ. 2014; 348: g129
- Erectile dysfunction.Lancet. 2013; 381: 153-165
- Clinical practice. Erectile dysfunction.N Engl J Med. 2007; 357: 2472-2481
- Erectile dysfunction.Nat Rev Dis Primers. 2016; 2: 16003
- A systematic review of the association between erectile dysfunction and cardiovascular disease.Eur Urol. 2014; 65: 968-978
- Erectile dysfunction in the cardiovascular patient.Eur Heart J. 2013; 34: 2034-2046
- The assessment of vascular risk in men with erectile dysfunction: the role of the cardiologist and general physician.Int J Clin Pract. 2013; 67: 1163-1172
- Sexual dysfunction and cardiovascular disease: integrative concepts and strategies.Am J Cardiol. 2005; 96: 57m-61m
- Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links.Eur Urol. 2007; 52: 1590-1600
- There is a link between erectile dysfunction and heart failure: it could be inflammation.Curr Drug Targets. 2015; 16: 442-450
- Prevalence and risk factors for erectile dysfunction in the US.Am J Med. 2007; 120: 151-157
- Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study.J Urol. 2001; 166 (discussion 574-565): 569-574
- Linking erectile dysfunction and coronary artery disease.Int J Impot Res. 2005; 17: S12-S18
- Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study.J Am Coll Cardiol. 2004; 43: 1405-1411
- Development and therapeutic applications of nitric oxide releasing materials to treat erectile dysfunction.Future Sci OA. 2015; 1 (FSO53)
- Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator.Heart. 2003; 89: 251-253
- Pathophysiology of erectile dysfunction.J Sex Med. 2005; 2: 26-39
- Biology of mitral valve prolapse: the harvest is big, but the workers are few.Int J Cardiol. 2011; 151: 129-135
- Identification of patients affected by mitral valve prolapse with severe regurgitation: a multivariable regression model.Oxid Med Cell Longev. 2017; 20176838921
- Increased nitric oxide release and expression of endothelial and inducible nitric oxide synthases in mildly changed porcine mitral valve leaflets.J Heart Valve Dis. 2007; 16: 67-75
- Floppy mitral valve/mitral valve prolapse/mitral valvular regurgitation: effects on the circulation.J Cardiol. 2001; 37: 15-20
Article info
Publication history
Published online: August 21, 2019
Received in revised form:
August 1,
2019
Received:
May 25,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
