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Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)

  • Shiu-Dong Chung
    Affiliations
    Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan

    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan
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  • Ju-Chi Liu
    Affiliations
    Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Division of Cardiovascular Medicine, Department of Medicine, Medical University Hospital–Shuang Ho Hospital, Taipei, Taiwan
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  • Tsai-Ning Lou
    Affiliations
    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
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  • Ben-Chang Shia
    Affiliations
    Big Data Research Center, Taipei Medical University, Taipei, Taiwan
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Herng-Ching Lin
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan

    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Li-Ting Kao
    Correspondence
    Corresponding author: Tel: 886-2-8792-3311 ext. 17629; fax: 886-2-8792-3171.
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan

    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

    Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan

    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
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  • Author Footnotes
    1 These authors contributed equally to this work.
      Some previous literature indicated an association between cardiovascular diseases and erectile dysfunction (ED). This case-control study purposed to evaluate the association between prior mitral valve prolapse (MVP) and ED using data from the Taiwan National Health Insurance Research Dataset. In this study, 48,755 patients with ED were identified as cases, and 195,020 propensity score-matched patients without ED were selected as controls. Conditional logistic regressions were conducted to evaluate the odds ratios (ORs) for previous MVP between cases and the matched controls. In all sampled patients, 4,565 (1.87%) patients had MVP before the index date. MVP was found in 1,304 (2.67%) cases and in 3,261 (1.67%) matched controls. Patients with ED had a significantly higher occurrence of MVP than the controls. In addition, after propensity score matching, a conditional logistic regression analysis showed that the OR of previous MVP for patients with ED was 1.63 (95% confidence interval [CI] 1.52 to 1.74) compared to the matched controls. The ORs of previous MVP for patients with ED aged ≤65 years and those >65 years were 1.68 (95% CI 1.56 to 1.81) and 1.49 (95% CI 1.30 to 1.70), respectively, compared with the matched controls. We found that patients with erectile dysfunction had significantly higher odds of previous MVP compared with matched control subjects without ED regardless of the age group.
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