Down syndrome (DS) remains the most common chromosomal disorder with the incidence
of 1 in 700 babies in the United States. DS increases the risk of respiratory and
congenital heart defects and therefore, increasing the need for extra life support.
1
Without surgery, congenital heart disease is a major source of morbidity and premature
death. The life expectancy of patients with DS without any congenital heart defects
is 60 to 70 years of age.
However, patients with congenital heart defects have 5 times higher risk of death
as compared with people without any congenital defects.
3
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References
- Congenital heart disease and Down syndrome: various aspects of a confirmed association.Cardiovasc J Afr. 2016; 27: 287-290
- Survival analysis of Down syndrome with congenital heart disease: a 5-years registry at QSNICH.J Med Assoc Thai. 2014; : S108-S114
- Extracorporeal membrane oxygenation characteristics and outcomes in adult patients with Down syndrome.Artif Organs. 2018; 42: 921-925
- Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study.JAMA. 1979; 242: 2193-2196
Article info
Publication history
Published online: August 23, 2019
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© 2019 Elsevier Inc. All rights reserved.
