Reports on development of frequent ventricular premature complexes (fVPC), (non)sustained
ventricular tachycardias ([n]sVT), or ventricular fibrillation (VF) and their interrelationship
in patients with different inherited cardiac arrhythmia (ICA) have sofar not been
reported. The aim of this study is therefore to examine incidences and recurrences
rates of sVT and VF (“malignant ventricular tachyarrhythmias, VTA”) in addition to
the incidence of fVPC and nsVT (“ventricular dysrhythmias, VDR”) in patients with
various ICA during long-term follow up. Patients (N = 167, 88 male, age 45 ± 15 years)
with ICA including definite/borderline arrhythmogenic right ventricular cardiomyopathy
(ARVC, N = 47), Brugada syndrome (BrS, N = 71), catecholaminergic polymorphic ventricular
tachycardia (CPVT, N = 7), long QT syndrome (LQTS, N = 41) or short QT syndrome (SQTS,
N = 1) who had frequent 24-hour Holter monitoring during a follow-up period of 4.6
± 4.4 years. During the initial screening visit, 15 patients had a history of malignant
VTA. fVPC and nsVT was observed in respectively 19% (OHCA/VF/sVT: N = 9) and 13% (OHCA/VF/sVT:
N = 4) of all patients. Compared with the ARVC group, patients with BrS and LQTS had
less frequent fVPC and nsVT (fVPC: odds ratio [OR] 0.20, 95% confidence interval [CI]
0.08 to 0.49, p <0.000 and OR 0.09, 95% CI 0.02 to 0.33, p <0.000; nsVT:OR 0.17, 95% CI 0.06 to 0.50, p = 0.001 and OR 0.09, 95% CI 0.02 to 0.46,
p = 0.003). The recurrence rate of malignant VTA was 33%. In conclusion, variety of VDR
and malignant VTA were found during long-term follow-up in patients with ICA. During
nearly a 5 years follow-up period, the recurrence rate of malignant VTA was considerable.
fVPC, nsVT, and malignant VTA were most often found in patients with an ARVC.
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Article info
Publication history
Published online: August 08, 2019
Received in revised form:
July 13,
2019
Received:
April 14,
2019
Identification
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© 2019 Elsevier Inc. All rights reserved.
