Advertisement
Review Article| Volume 123, ISSUE 8, P1370-1377, April 15, 2019

Benefits and Risks of High-Intensity Interval Training in Patients With Coronary Artery Disease

Published:January 23, 2019DOI:https://doi.org/10.1016/j.amjcard.2019.01.008
      Exercise-based cardiac rehabilitation is integral to secondary prevention in patients with coronary artery disease. Recently, the effectiveness and “superiority” of high-intensity interval training (HIIT) is a purported time-saving alternative to “traditional” moderate-intensity continuous training (MICT) in cardiac rehabilitation. The rationale for HIIT adoption is, however, not fully substantiated in the scientific literature. Established guidelines for exercise testing and training, when carefully adhered to, reduce the likelihood of triggering a cardiac event or inducing musculoskeletal injury. Clinicians should likewise consider patient risk stratification and introduce HIIT as an alternative to MICT only after patients exhibit stable and asymptomatic responses to vigorous exercise training. Although HIIT adherence appears comparable with MICT during outpatient rehabilitation, compliance drops dramatically for unsupervised exercise. Despite the enthusiasm surrounding HIIT, its main advantage over MICT appears to be short-term exercise performance outcomes and indices of vascular function. Regarding benefits to cardiovascular disease risk factor modification, management of vital signs, and measures of cardiac performance, current evidence indicates that HIIT does not outperform MICT. Long-term outcomes to HIIT are currently uncertain and logistical constraints to HIIT incorporation need additional clarification. Based on these limited findings, derived from facilities and clinicians at the forefront of cardiac rehabilitation, the routine adoption of HIIT should be viewed cautiously. In conclusion, the current review highlights numerous specific research directives that are needed before the safety and effectiveness of HIIT can be confirmed and widely adopted in patients with known or suspected coronary artery disease, especially in unsupervised, nonmedical settings.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Quindry JC
        • Franklin BA
        Cardioprotective exercise and pharmacologic interventions as complementary antidotes to cardiovascular disease.
        Exerc Sport Sci Rev. 2018; 46: 5-17
        • Pirruccello JP
        • Traynor K
        • Aragam KG
        “Road Map” to improving enrollment in cardiac rehabilitation: identifying barriers and evaluating alternatives.
        J Am Heart Assoc. 2017; 6: 1-3
        • Gayda M
        • Ribeiro PA
        • Juneau M
        • Nigam A
        Comparison of different forms of exercise training in patients with cardiac disease: where does high-intensity interval training fit?.
        Can J Cardiol. 2016; 32: 485-494
        • Blackwell JEM
        • Doleman B
        • Herrod PJJ
        • Ricketts S
        • Phillips BE
        • Lund JN
        • Williams JP
        Short-term (<8 wk) high-intensity interval training in diseased cohorts.
        Med Sci Sports Exerc. 2018; 50: 1740-1749
        • Ribeiro PA
        • Boidin M
        • Juneau M
        • Nigam A
        • Gayda M
        High-intensity interval training in patients with coronary heart disease: prescription models and perspectives.
        Ann Phys Rehabil Med. 2017; 60: 50-57
        • Keteyian SJ
        • Hibner BA
        • Bronsteen K
        • Kerrigan D
        • Aldred HA
        • Reasons LM
        • Saval MA
        • Brawner CA
        • Schairer JR
        • Thompson TM
        • Hill J
        • McCulloch D
        • Ehrman JK
        Greater improvement in cardiorespiratory fitness using higher-intensity interval training in the standard cardiac rehabilitation setting.
        J Cardiopulm Rehabil Prev. 2014; 34: 98-105
        • Rognmo Ø
        • Hetland E
        • Helgerud J
        • Hoff J
        • Slørdahl SA
        High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease.
        Eur J Cardiovasc Preven Rehabil. 2016; 11: 216-222
        • Rognmo O
        • Moholdt T
        • Bakken H
        • Hole T
        • Molstad P
        • Myhr NE
        • Grimsmo J
        • Wisloff U
        Cardiovascular risk of high- versus moderate-intensity aerobic exercise in coronary heart disease patients.
        Circulation. 2012; 126: 1436-1440
        • Warburton DE
        • McKenzie DC
        • Haykowsky MJ
        • Taylor A
        • Shoemaker P
        • Ignaszewski AP
        • Chan SY
        Effectiveness of high-intensity interval training for the rehabilitation of patients with coronary artery disease.
        Am J Cardiol. 2005; 95: 1080-1084
        • Jaureguizar KV
        • Vicente-Campos D
        • Bautista LR
        • de la Pena CH
        • Gomez MJ
        • Rueda MJ
        • Fernandez Mahillo I
        Effect of high-intensity interval versus continuous exercise training on functional capacity and quality of life in patients with coronary artery disease: a randomized clinical trial.
        J Cardiopulm Rehabil Prev. 2016; 36: 96-105
        • Ross LM
        • Porter RR
        • Durstine JL
        High-intensity interval training (HIIT) for patients with chronic diseases.
        J Sport Health Sci. 2016; 5: 139-144
        • Gibala MJ
        • Little JP
        • Macdonald MJ
        • Hawley JA
        Physiological adaptations to low-volume, high-intensity interval training in health and disease.
        J Physiol. 2012; 590: 1077-1084
        • Tschentscher M
        • Eichinger J
        • Egger A
        • Droese S
        • Schonfelder M
        • Niebauer J
        High-intensity interval training is not superior to other forms of endurance training during cardiac rehabilitation.
        Eur J Prev Cardiol. 2016; 23: 14-20
        • Cardozo GG
        • Oliveira RB
        • Farinatti PT
        Effects of high intensity interval versus moderate continuous training on markers of ventilatory and cardiac efficiency in coronary heart disease patients.
        Sci World J. 2015; 2015192479
        • Amundsen BH
        • Rognmo O
        • Hatlen-Rebhan G
        • Slordahl SA
        High-intensity aerobic exercise improves diastolic function in coronary artery disease.
        Scand Cardiovasc J. 2008; 42: 110-117
        • Moholdt TT
        • Amundsen BH
        • Rustad LA
        • Wahba A
        • Lovo KT
        • Gullikstad LR
        • Bye A
        • Skogvoll E
        • Wisloff U
        • Slordahl SA
        Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life.
        Am Heart J. 2009; 158: 1031-1037
        • Beatty AL
        • Ku IA
        • Christenson RH
        • DeFilippi CR
        • Schiller NB
        • Whooley MA
        High-sensitivity cardiac troponin T levels and secondary events in outpatients with coronary heart disease from the Heart and Soul Study.
        JAMA Intern Med. 2013; 173: 763-769
        • Eskelinen JJ
        • Heinonen I
        • Loyttyniemi E
        • Hakala J
        • Heiskanen MA
        • Motiani KK
        • Virtanen K
        • Parkka JP
        • Knuuti J
        • Hannukainen JC
        • Kalliokoski KK
        Left ventricular vascular and metabolic adaptations to high-intensity interval and moderate intensity continuous training: a randomized trial in healthy middle-aged men.
        J Physiol. 2016; 594: 7127-7140
        • Conraads VM
        • Pattyn N
        • De Maeyer C
        • Beckers PJ
        • Coeckelberghs E
        • Cornelissen VA
        • Denollet J
        • Frederix G
        • Goetschalckx K
        • Hoymans VY
        • Possemiers N
        • Schepers D
        • Shivalkar B
        • Voigt JU
        • Van Craenenbroeck EM
        • Vanhees L
        Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: the SAINTEX-CAD study.
        Int J Cardiol. 2015; 179: 203-210
        • Currie KD
        • Dubberley JB
        • McKelvie RS
        • MacDonald MJ
        Low-volume, high-intensity interval training in patients with CAD.
        Med Sci Sports Exerc. 2013; 45: 1436-1442
        • Haskell WL
        • Lee IM
        • Pate RR
        • Powell KE
        • Blair SN
        • Franklin BA
        • Macera CA
        • Heath GW
        • Thompson PD
        • Bauman A
        Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association.
        Circulation. 2007; 116: 1081-1093
        • Pattyn N
        • Vanhees L
        • Cornelissen VA
        • Coeckelberghs E
        • De Maeyer C
        • Goetschalckx K
        • Possemiers N
        • Wuyts K
        • Van Craenenbroeck EM
        • Beckers PJ
        The long-term effects of a randomized trial comparing aerobic interval versus continuous training in coronary artery disease patients: 1-year data from the SAINTEX-CAD study.
        Eur J Prev Cardiol. 2016; 23: 1154-1164
        • Moholdt T
        • Aamot IL
        • Granoien I
        • Gjerde L
        • Myklebust G
        • Walderhaug L
        • Brattbakk L
        • Hole T
        • Graven T
        • Stolen TO
        • Amundsen BH
        • Molmen-Hansen HE
        • Stoylen A
        • Wisloff U
        • Slordahl SA
        Aerobic interval training increases peak oxygen uptake more than usual care exercise training in myocardial infarction patients: a randomized controlled study.
        Clin Rehabil. 2012; 26: 33-44
        • Rognmo O
        • Hetland E
        • Helgerud J
        • Hoff J
        • Slordahl SA
        High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease.
        Eur J Cardiovasc Prev Rehabil. 2004; 11: 216-222
        • Gomes-Neto M
        • Duraes AR
        • Reis H
        • Neves VR
        • Martinez BP
        • Carvalho VO
        High-intensity interval training versus moderate-intensity continuous training on exercise capacity and quality of life in patients with coronary artery disease: a systematic review and meta-analysis.
        Eur J Prev Cardiol. 2017; 24: 1696-1707
        • Vanhees L
        • Fagard R
        • Thijs L
        • Staessen J
        • Amery A
        Prognostic significance of peak exercise capacity in patients with coronary artery disease.
        J Am Coll Cardiol. 1994; 23: 358-363
        • Martin BJ
        • Arena R
        • Haykowsky M
        • Hauer T
        • Austford LD
        • Knudtson M
        • Aggarwal S
        • Stone JA
        • Investigators A
        Cardiovascular fitness and mortality after contemporary cardiac rehabilitation.
        Mayo Clin Proc. 2013; 88: 455-463
        • Elliott AD
        • Rajopadhyaya K
        • Bentley DJ
        • Beltrame JF
        • Aromataris EC
        Interval training versus continuous exercise in patients with coronary artery disease: a meta-analysis.
        Heart Lung Circ. 2015; 24: 149-157
        • Wisloff U
        • Stoylen A
        • Loennechen JP
        • Bruvold M
        • Rognmo O
        • Haram PM
        • Tjonna AE
        • Helgerud J
        • Slordahl SA
        • Lee SJ
        • Videm V
        • Bye A
        • Smith GL
        • Najjar SM
        • Ellingsen O
        • Skjaerpe T
        Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study.
        Circulation. 2007; 115: 3086-3094
        • Arnardottir RH
        • Boman G
        • Larsson K
        • Hedenstrom H
        • Emtner M
        Interval training compared with continuous training in patients with COPD.
        Respir Med. 2007; 101: 1196-1204
        • Vromen T
        • Kraal JJ
        • Kuiper J
        • Spee RF
        • Peek N
        • Kemps HM
        The influence of training characteristics on the effect of aerobic exercise training in patients with chronic heart failure: a meta-regression analysis.
        Int J Cardiol. 2016; 208: 120-127
        • Moholdt T
        • Bekken Vold M
        • Grimsmo J
        • Slordahl SA
        • Wisloff U
        Home-based aerobic interval training improves peak oxygen uptake equal to residential cardiac rehabilitation: a randomized, controlled trial.
        PLoS One. 2012; 7: e41199
        • Torri A
        • Panzarino C
        • Scaglione A
        • Modica M
        • Bordoni B
        • Redaelli R
        • De Maria R
        • Ferratini M
        Promotion of home-based exercise training as secondary prevention of coronary heart disease: a pilot web-based intervention.
        J Cardiopulm Rehabil Prev. 2018; 38: 253-258
        • Roy M
        • Williams SM
        • Brown RC
        • Meredith-Jones KA
        • Osborne H
        • Jospe M
        • Taylor RW
        HIIT in the real world: outcomes from a 12-month intervention in overweight adults.
        Med Sci Sports Exerc. 2018;
        • Laurent CM
        • Vervaecke LS
        • Kutz MR
        • Green JM
        Sex-specific responses to self-paced, high-intensity interval training with variable recovery periods.
        J Strength Cond Res. 2014; 28: 920-927
        • Siscovick DS
        • Weiss NS
        • Fletcher RH
        • Lasky T
        The incidence of primary cardiac arrest during vigorous exercise.
        N Engl J Med. 1984; 311: 874-877
        • Cornish AK
        • Broadbent S
        • Cheema BS
        Interval training for patients with coronary artery disease: a systematic review.
        Eur J Appl Physiol. 2011; 111: 579-589
        • Thompson PD
        • Franklin BA
        • Balady GJ
        • Blair SN
        • Corrado D
        • Estes NA
        • 3rd, Fulton JE
        • Gordon NF
        • Haskell WL
        • Link MS
        • Maron BJ
        • Mittleman MA
        • Pelliccia A
        • Wenger NK
        • Willich SN
        • Costa F
        American Heart Association Council on nutrition PA, metabolism, American Heart Association Council on clinical C, American College of Sports M. exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on nutrition, physical activity, and metabolism and the Council on Clinical Cardiology.
        Circulation. 2007; 115: 2358-2368
        • Stenroth L
        • Peltonen J
        • Cronin NJ
        • Sipila S
        • Finni T
        Age-related differences in Achilles tendon properties and triceps surae muscle architecture in vivo.
        J Appl Physiol (1985). 2012; 113: 1537-1544
        • Dunlay SM
        • Witt BJ
        • Allison TG
        • Hayes SN
        • Weston SA
        • Koepsell E
        • Roger VL
        Barriers to participation in cardiac rehabilitation.
        Am Heart J. 2009; 158: 852-859