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Do Not Forget Physical Activity and Cardiorespiratory Fitness

      We read with great interest the superb experiential review by Roberts,
      • Roberts WC.
      Quantitative extent of atherosclerotic plaque in the major epicardial coronary arteries in patients with fatal coronary heart disease, in coronary endarterectomy specimens, in aorta-coronary saphenous venous conduits, and means to prevent the plaques: a review after studying the coronary arteries for 50 years.
      addressing 15 common questions related to the pathophysiology and development of coronary artery disease, highlighting the fact that aggressive lipid lowering therapy can effectively prevent the otherwise inexorable progression of atherosclerotic plaques and their adverse sequelae.
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