Chronic obstructive pulmonary disease (COPD) is a major health problem that contributes
to substantial morbidity and mortality globally. This study investigated the relation
between COPD and the risk of cardiovascular disease in the general population. We
evaluated the cardiovascular effect of COPD using Korean National Health Insurance
Service data from 2002 to 2013. We compared selected cardiovascular disease risk factors
depending on pulmonary function using the Korean Health and Nutritional Examination
Survey (KNHANES, n = 24,429) data. COPD was diagnosed in 11,771 patients (2.4%) in
the National Health Insurance Service cohort. During the follow-up period (45.5 ± 14.9
months), subjects with COPD had lower cumulative survival rate for all-cause mortality,
cardiovascular mortality, and sudden cardiac death (SCD, all p values <0.001). COPD
was associated with an increased risk of all-cause mortality even after adjustment
for potential confounding variables (hazard ratio [HR] 1.43, 95% confidence interval
[CI] 1.33 to 1.55, p <0.001). However, COPD did not significantly increase the risk
of cardiovascular mortality (HR 1.02, 95% CI 0.84 to 1.22, p = 0.876) and SCD (HR
1.07, 95% CI 0.79 to 1.44, p = 0.664) when adjusted for potential confounding variables.
Analysis of the KNHANES cohort showed that systolic blood pressure, current smoking
status, and Framingham risk score increased progressively with a decrease in pulmonary
function (all p <0.001). In conclusion, COPD was associated with all-cause mortality,
but not with cardiovascular mortality and SCD, whereas poor pulmonary function was
associated with a heightened cardiovascular risk.
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Article Info
Publication History
Published online: July 25, 2017
Accepted:
July 10,
2017
Received:
February 26,
2017
Footnotes
This research was supported by grant NRF-2017R1A2B3003303 from the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning, and by grants HI16C0058 and HI15C1200 from the Korean Healthcare Technology R&D Project funded by the Ministry of Health and Welfare, Daejon.
See page 1403 for disclosure information.
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