Some previous studies have proposed the electrocardiographic Tpeak-Tend (TpTe) as
a possible predictor of ventricular arrhythmic events in patients with Brugada syndrome
(BrS). We sought to analyze the association between the parameters of repolarization
dispersion (TpTe, TpTe/QT, TpTe dispersion, QTc, and QTd) and ventricular fibrillation/sudden
cardiac death in a large cohort of patients with type 1 BrS. A total of 448 consecutive
patients with BrS (men 61%, age 45 ± 16 years) with spontaneous (n = 96, 21%) or drug-induced
(n = 352, 79%) type 1 electrocardiogram were retrospectively included. At the time
of the diagnosis or during a mean follow-up of 93 ± 47 months (median 88 months),
43 patients (9%) documented ventricular arrhythmias. No significant difference was
observed in TpTe, TpTe/QT, maximum TpTe, and TpTe dispersion between asymptomatic
patients and those with syncope and malignant arrhythmias. TpTe/QT ratio did not also
significantly differ between patients with ventricular fibrillation/sudden cardiac
death and those asymptomatic ones. In conclusion, TpTe was not significantly prolonged
in those patients with type 1 BrS presenting with unexplained syncope or malignant
arrhythmic events during follow-up.
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Article Info
Publication History
Published online: July 24, 2017
Accepted:
July 7,
2017
Received:
May 1,
2017
Footnotes
See page 1337 for disclosure information.
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
