Myriads of physical stress factors including pheochromocytoma have been reported triggering
takotsubo syndrome (TS). The aim of this study was to report on the clinical features
and outcome of pheochromocytoma-induced TS (Pheo-TS) in a large cohort of patients.
Eighty published cases of Pheo-TS were retrieved from the literature and compared
with 1,750 cases of all patients with TS (All-TS) published recently by Templin et al.
Patients with Pheo-TS were on average 19.87 years younger than those with All-TS (p
<0.0001). The women were still predominating in Pheo-TS but significantly in a lower
percentage (70% in Pheo-TS vs 89.8% in All-TS, p <0.00001). Almost 1/3 (30%) of Pheo-TS
cases had basal TS pattern compared with 2.2% of cases in All-TS (p <0.00001) and
1/5 (20%) had global TS compared with no cases in All-TS. Two thirds of Pheo-TS cases
(67.9%) developed complications, which was significantly higher than complication
rates in All-TS (21.8%), but there was no difference in the inhospital mortality between
the 2 studies. The most important risk factors for the development of complications
in Pheo-TS were age <50 years and global and basal TS localization patterns. The recurrence
rate of 17.7% in Pheo-TS was significantly higher than the 3.26% in All-TS (p <0.00001).
In conclusion, Pheo-TS is characterized by a dramatic clinical presentation with high
complication rates and relatively high recurrence rate. Patients with Pheo-TS are
significantly younger than All-TS. The TS localization pattern in Pheo-TS differed
significantly from All-TS with basal pattern in almost 1/3 of cases and global pattern
in 1/5 of the cases.
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Article info
Publication history
Published online: March 19, 2016
Accepted:
March 1,
2016
Received in revised form:
March 1,
2016
Received:
December 19,
2015
Footnotes
See page 1843 for disclosure information.
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© 2016 Elsevier Inc. All rights reserved.
