The development of atrial fibrillation (AF) after cardiac surgery is a major complication,
occurring in 10% to 65% of patients.
1
Despite the increasing number of studies on this issue, the pathophysiologic mechanisms
leading to the postoperative AF after cardiac surgeries have not been precisely elucidated;
however, some pathogenesis, including the electrophysiological remodeling of atrium,
inflammation, and oxidative stress, have been hypothesized to be involved in this
process.
- Patti G.
- Chello M.
- Candura D.
- Pasceri V.
- D'Ambrosio A.
- Covino E.
- Di Sciascio G.
Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation
in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for
Reduction of MYocardial Dysrhythmia After cardiac surgery) study.
Circulation. 2006; 114: 1455-1461
2
It has been postulated that inflammation has a paramount role in the perpetuation
of AF after cardiac surgery.
3
Moreover, using cardiopulmonary bypass at cardiac surgery leads to complement activation
and the subsequent elevation of CRP.
4
- Bruins P.
- te Velthuis H.
- Yazdanbakhsh A.P.
- Jansen P.G.
- van Hardevelt F.W.
- de Beaumont E.M.
- Wildevuur C.R.
- Eijsman L.
- Trouwborst A.
- Hack C.E.
Activation of the complement system during and after cardiopulmonary bypass surgery:
postsurgery activation involves C-reactive protein and is associated with postoperative
arrhythmia.
Circulation. 1997; 96: 3542-3548
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References
- Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study.Circulation. 2006; 114: 1455-1461
- Atorvastatin reduces the incidence of postoperative atrial fibrillation in statin-naive patients undergoing isolated heart valve surgery: a double-blind, placebo-controlled randomized trial.J Cardiovasc Pharmacol Ther. 2015; 20: 465-472
- Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data.J Am Coll Cardiol. 2007; 50: 2021-2028
- Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia.Circulation. 1997; 96: 3542-3548
- Meta-analysis of 12 trials evaluating the effects of statins on decreasing atrial fibrillation after coronary artery bypass grafting.Am J Cardiol. 2015; 115: 1523-1528
Article Info
Publication History
Published online: November 09, 2015
Received:
October 25,
2015
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
