People with type 1 diabetes mellitus manifest a greater burden of both periodontal
disease and coronary artery disease (CAD); however, little is known about their interrelation.
Coronary artery calcium (CAC) measures subclinical atherosclerosis and predicts major
adverse coronary events. The relation between periodontal disease and CAC progression
in individuals with type 1 diabetes has not been previously described. We determined
the prevalence and progression of CAC in relation to self-reported periodontal disease.
Multivariate logistic and tobit regression models were used to examine the relation
between periodontal disease duration and CAC progression and whether this relation
differs by diabetes status after controlling for age, gender, total and high-density
lipoprotein cholesterol, hypertension, smoking, body mass index (BMI), duration of
diabetes, and baseline CAC. A total of 473 patients with type 1 diabetes and 548 without
diabetes were followed for a mean of 6.1 years. At baseline, the prevalence and duration
of periodontal disease did not differ between subjects with and without diabetes (14.5%
vs 13.4%, p = 0.60; 6 vs 9 years, p = 0.18). Duration of periodontal disease was not
significantly associated with baseline CAC prevalence. In patients with type 1 diabetes,
periodontal disease duration was significantly related to CAC progression (p = 0.004)
but not in subjects without diabetes (p = 0.63). In conclusion, this study suggests
that periodontal disease is an independent predictor of long-term progression of CAC
in patients with type 1 diabetes.
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Article Info
Publication History
Published online: June 24, 2015
Accepted:
June 6,
2015
Received in revised form:
June 6,
2015
Received:
April 5,
2015
Footnotes
See page 837 for disclosure information.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
