Advertisement

Relation of Polymorphism of the Histidine Decarboxylase Gene to Chronic Heart Failure in Han Chinese

      Histidine decarboxylase (HDC) is a key determinant of the levels of endogenous histamine that has long been recognized to play important pathophysiological roles during development of chronic heart failure (CHF). Meanwhile, certain genetic variants in HDC gene were reported to affect the function of HDC and associated with histamine-related diseases. However, the relation between polymorphisms of HDC gene and CHF risk remains unclear. This study aims to investigate the associations between 2 nonsynonymous HDC polymorphisms (rs17740607 and rs2073440) and CHF. We designed a 2-stage case–control study, in which we genotyped 439 patients with CHF and 467 healthy controls recruited in Xi'an, China, and replicated this study in 413 patients with CHF and 452 healthy subjects in Kunming, China. We also performed in vitro experiments to further validate the functional consequences of variants positively associated with CHF. The rs17740607 polymorphism showed replicated associations with all-cause CHF according to genotype and allele distribution and also under a dominant and additive genetic model after adjusted for traditional cardiovascular-related factors. Functional experiments further demonstrated that rs17740607 polymorphism decreased the HDC activity. In conclusion, HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against CHF, which provides novel highlights for investigating the contribution of CHF.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Morita H.
        • Seidman J.
        • Seidman C.E.
        Genetic causes of human heart failure.
        J Clin Invest. 2005; 115: 518-526
        • Mackins C.J.
        • Kano S.
        • Seyedi N.
        • Schafer U.
        • Reid A.C.
        • Machida T.
        • Silver R.B.
        • Levi R.
        Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.
        J Clin Invest. 2006; 116: 1063-1070
        • Luo T.
        • Chen B.
        • Zhao Z.
        • He N.
        • Zeng Z.
        • Wu B.
        • Fukushima Y.
        • Dai M.
        • Huang Q.
        • Xu D.
        • Bin J.
        • Kitakaze M.
        • Liao Y.
        Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function.
        Basic Res Cardiol. 2013; 108: 342-355
        • He G.
        • Hu J.
        • Li T.
        • Ma X.
        • Meng J.
        • Jia M.
        • Lu J.
        • Ohtsu H.
        • Chen Z.
        • Luo X.
        The arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemia.
        Mol Med. 2012; 18: 1-9
        • Tanimoto A.
        • Sasaguri Y.
        • Ohtsu H.
        Histamine network in atherosclerosis.
        Trends Cardiovasc Med. 2006; 16: 280-284
        • Campos H.A.
        • Montenegro M.
        • Velasco M.
        • Romero E.
        • Alvarez R.
        • Urbina A.
        Treadmill exercise-induced stress causes a rise of blood histamine in normotensive but not in primary hypertensive humans.
        Eur J Pharmacol. 1999; 383: 69-73
        • Ishiwata Y.
        • Yasuhara M.
        Gatifloxacin-induced histamine release and hyperglycemia in rats.
        Eur J Pharmacol. 2010; 645: 192-197
        • Kim J.
        • Ogai A.
        • Nakatani S.
        • Hashimura K.
        • Kanzaki H.
        • Komamura K.
        • Asakura M.
        • Asanuma H.
        • Kitamura S.
        • Tomoike H.
        • Kitakaze M.
        Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies.
        J Am Coll Cardiol. 2006; 48: 1378-1384
        • Zeng Z.
        • Shen L.
        • Li X.
        • Luo T.
        • Wei X.
        • Zhang J.
        • Cao S.
        • Huang X.
        • Fukushima Y.
        • Bin J.
        • Kitakaze M.
        • Xu D.
        • Liao Y.
        Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.
        Clin Sci. 2014; 127: 435-448
        • Gervasini G.
        • Agúndez J.A.
        • García-Menaya J.
        • Martínez C.
        • Cordobés C.
        • Ayuso P.
        • Cornejo J.A.
        • Blanca M.
        • García-Martín E.
        Variability of the L-Histidine decarboxylase gene in allergic rhinitis.
        Allergy. 2010; 65: 1576-1584
        • Zhang F.
        • Xiong D.H.
        • Wang W.
        • Shen H.
        • Xiao P.
        • Yang F.
        • Recker R.R.
        • Deng H.W.
        HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.
        Biochem Biophys Res Commun. 2006; 348: 1378-1382
        • He G.H.
        • Lin J.J.
        • Cai W.K.
        • Xu W.M.
        • Yu Z.P.
        • Yin S.J.
        • Zhao C.H.
        • Xu G.L.
        Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
        PLoS One. 2014; 9: e97728
        • García-Martín E.
        • Ayuso P.
        • Martínez C.
        • Blanca M.
        • Agúndez J.A.
        Histamine pharmacogenomics.
        Pharmacogenomics. 2009; 10: 867-883
        • McKee P.A.
        • Castelli W.P.
        • McNamara P.M.
        • Kannel W.B.
        The natural history of congestive heart failure: the Framingham study.
        N Engl J Med. 1971; 285: 1441-1446
        • He G.H.
        • Lu J.
        • Shi P.P.
        • Xia W.
        • Yin S.J.
        • Jin T.B.
        • Chen D.D.
        • Xu G.L.
        Polymorphisms of human histamine receptor H4 gene are associated with breast cancer in Chinese Han population.
        Gene. 2013; 519: 260-265
        • Furuta K.
        • Nakayama K.
        • Sugimoto Y.
        • Ichikawa A.
        • Tanaka S.
        Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815.
        J Biol Chem. 2007; 282: 13438-13446
        • Previati M.
        • Raspadori A.
        • Bertolaso L.
        • Parmeggiani A.
        • Bindini D.
        • Vitali C.
        • Lanzoni I.
        • Corbacella E.
        • Saviano M.
        • Fagioli F.
        • Blo G.
        • Capitani S.
        Determination of histamine in the whole blood of colon cancer patients.
        J Chromatogr B Analyt Technol Biomed Life Sci. 2002; 780: 331-339
        • Parsons M.E.
        • Ganellin C.R.
        Histamine and its receptors.
        Br J Pharmacol. 2006; 147: S127-S135
        • Takahama H.
        • Asanuma H.
        • Sanada S.
        • Fujita M.
        • Sasaki H.
        • Wakeno M.
        • Kim J.
        • Asakura M.
        • Takashima S.
        • Minamino T.
        • Komamura K.
        • Sugimachi M.
        • Kitakaze M.
        A histamine H2 receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.
        Basic Res Cardiol. 2010; 105: 787-794
        • Hara M.
        • Ono K.
        • Hwang M.W.
        • Iwasaki A.
        • Okada M.
        • Nakatani K.
        • Sasayama S.
        • Matsumori A.
        Evidence for a role of mast cells in the evolution to congestive heart failure.
        J Exp Med. 2002; 195: 375-381
        • Panizo A.
        • Mindán F.J.
        • Galindo M.F.
        • Cenarruzabeitia E.
        • Hernández M.
        • Díez J.
        Are mast cells involved in hypertensive heart disease?.
        J Hypertens. 1995; 13: 1201-1208
        • Patella V.
        • Marinò I.
        • Arbustini E.
        • Lamparter-Schummert B.
        • Verga L.
        • Adt M.
        • Marone G.
        Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy.
        Circulation. 1998; 97: 971-978
        • Frangogiannis N.G.
        • Perrard J.L.
        • Mendoza L.H.
        • Burns A.R.
        • Lindsey M.L.
        • Ballantyne C.M.
        • Michael L.H.
        • Smith C.W.
        • Entman M.L.
        Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion.
        Circulation. 1998; 98: 687-698
        • Laine P.
        • Kaartinen M.
        • Penttilä A.
        • Panula P.
        • Paavonen T.
        • Kovanen P.T.
        Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery.
        Circulation. 1999; 99: 361-369
        • Li M.
        • Hu J.
        • Chen Z.
        • Meng J.
        • Wang H.
        • Ma X.
        • Luo X.
        Evidence for histamine as a neurotransmitter in the cardiac sympathetic nervous system.
        Am J Physiol. 2006; 291: H45-H51
        • He G.
        • Hu J.
        • Ma X.
        • Li M.
        • Wang H.
        • Meng J.
        • Jia M.
        • Luo X.
        Sympathetic histamine exerts different pre- and post-synaptic functions according to the frequencies of nerve stimulation in guinea pig vas deferens.
        J Neurochem. 2008; 106: 1710-1719
        • Hashikawa-Hobara N.
        • Chan N.Y.
        • Levi R.
        Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart.
        J Pharmacol Exp Ther. 2012; 340: 185-191
        • Aldi S.
        • Takano K.
        • Tomita K.
        • Koda K.
        • Chan N.Y.
        • Marino A.
        • Salazar-Rodriguez M.
        • Thurmond R.L.
        • Levi R.
        Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.
        J Pharmacol Exp Ther. 2014; 349: 508-517
        • Nijenhuis W.A.
        • Garner K.M.
        • van Rozen R.J.
        • Adan R.A.
        Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.
        J Biol Chem. 2003; 278: 22939-22945
        • Hamilton P.J.
        • Campbell N.G.
        • Sharma S.
        • Erreger K.
        • Herborg Hansen F.
        • Saunders C.
        • Belovich A.N.
        • Sahai M.A.
        • Cook E.H.
        • Gether U.
        • McHaourab H.S.
        • Matthies H.J.
        • Sutcliffe J.S.
        • Galli A.
        • NIH ARRA Autism Sequencing Consortium
        De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder.
        Mol Psychiatry. 2013; 18: 1315-1323