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PETER RUSSELL KOWEY, MD: a conversation with the editor

      Peter Kowey was born in Norristown, Pennsylvania, January 4, 1950, and that is where he grew up. He graduated from Bishop Kendrick High School in June 1967 as Salutatorian and received a Presidential Scholarship to St. Joseph's College in Philadelphia where he graduated in May 1971, Cum Laude with a BS in Biology and was a member of the Alpha Sigma Nu honors program. From there he went to the University of Pennsylvania in Philadelphia for medical school graduating in 1975. His internship in internal medicine was at the Milton S. Hershey Medical Center, Philadelphia, in Hershey, Pennsylvania, and his fellowship in cardiology was at the Harvard University School of Public Health and Peter Bent Brigham Hospital in Boston, finishing in June 1981. His major mentor was Dr. Bernard Lown. After completing his cardiology fellowship, he returned to Philadelphia, joining the Medical College of Pennsylvania as director of the coronary care unit and of the cardiac arrhythmia service. He rose to full Professor of Medicine and Pharmacology by 1990. He became chief of the division of cardiovascular diseases of the Mainline Health System, Bryn Mawr, Lankenau and Paoli Memorial Hospitals in 1999 and has remained in that position to the present. He also occupies the William Wykoff Smith Chair in Cardiovascular Research. From 1990 until the present he is also Professor of Medicine and of Clinical Pharmacology at Jefferson Medical College of The Thomas Jefferson University in Philadelphia. He was Clinical Professor of Medicine at MCP/Hahnemann/Drexel University College of Medicine from 1992 - 2003. He also serves as president of The Heart Center of Lankenau, Bryn Mawr, and Paoli Memorial Hospitals.
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      Best Publications of Peter Russell Kowey Selected by Peter Russell Kowey, MD, Listed by the Number in His Curriculum Vitae:

        • Kowey P.R.
        • Friedman P.L.
        • Podrid P.J.
        • Zielonka J.
        • Lown B.
        • Wynne J.
        • Holman B.L.
        Use of radionuclide ventriculography for assessment of changes in myocardial performance induced by disopyramide phosphate.
        Am Heart J. 1982; 104: 769-774
        • Kowey P.R.
        • Verrier R.L.
        • Lown B.
        • Handin R.I.
        Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis.
        Am J Cardiol. 1983; 51: 596-602
        • Kowey P.R.
        • Eisenberg R.
        • Engel T.R.
        Sustained arrhythmias in hypertrophic obstructive cardiomyopathy.
        N Engl J Med. 1984; 310: 1566-1569
        • Zukerman L.S.
        • Friehling T.D.
        • Wolf N.M.
        • Meister S.G.
        • Nahass G.
        • Kowey P.R.
        Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography.
        J Am Coll Cardiol. 1987; 10: 1249-1253
        • Kowey P.R.
        • Friehling T.D.
        • Marinchak R.A.
        • Kline R.A.
        • Stohler J.L.
        • Yeager L.A.
        The case for explantation of the automatic implantable cardioverter-defibrillator.
        Am J Cardiol. 1987; 59: 1210-1211
        • Kowey P.R.
        • Friehling T.D.
        • Marinchak R.A.
        • Sulpizi A.M.
        • Stohler J.L.
        Safety and efficacy of amiodarone. The low-dose perspective.
        Chest. 1988; 93: 54-59
        • Kowey P.R.
        • Fisher L.
        • Giardina E.G.
        • Leier C.V.
        • Lowenthal D.T.
        • Messerli F.H.
        • Pratt C.M.
        The TPA controversy and the drug approval process. The view of the Cardiovascular and Renal Drugs Advisory Committee.
        JAMA. 1988; 260: 2250-2252
        • Luketich J.
        • Friehling T.D.
        • O'Connor K.M.
        • Kowey P.R.
        The effect of beta-adrenergic blockade on vulnerability to ventricular fibrillation and inducibility of ventricular arrhythmia in short- and long-term feline infarction models.
        Am Heart J. 1989; 118: 265-271
        • O'Connor K.M.
        • Friehling T.D.
        • Kowey P.R.
        The effect of thromboxane inhibition on vulnerability to ventricular fibrillation in the acute and chronic feline infarction models.
        Am Heart J. 1989; 117: 848-853
        • Kowey P.R.
        • Waxman H.L.
        • Greenspon A.
        • Greenberg R.
        • Poll D.
        • Kutalek S.
        • Gessman L.
        • Muenz L.
        Value of electrophysiologic testing in patients with previous myocardial infarction and nonsustained ventricular tachycardia. Philadelphia Arrhythmia Group.
        Am J Cardiol. 1990; 65: 594-598
        • Pratt C.M.
        • Brater D.C.
        • Harrell Jr., F.E.
        • Kowey P.R.
        • Leier C.V.
        • Lowenthal D.T.
        • Messerli F.
        • Packer M.
        • Pritchett E.L.
        • Ruskin J.N.
        Clinical and regulatory implications of the Cardiac Arrhythmia Suppression Trial.
        Am J Cardiol. 1990; 65: 103-105
        • Messerlia F.H.
        • Kowey P.R.
        • Grodzickic T.
        Sublingual nifedipine for hypertensive emergencies.
        The Lancet. 1991; 338 (Letters to the Editor): 881
        • Kowey P.R.
        • Taylor J.E.
        • Rials S.J.
        • Marinchak R.A.
        Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting.
        Am J Cardiol. 1992; 69: 963-965
        • Hernández M.
        • Taylor J.
        • Marinchak R.
        • Rials S.
        • Rubin A.
        • Kowey P.
        Outcome of patients with nonsustained ventricular tachycardia and severely impaired ventricular function who have negative electrophysiologic studies.
        Am Heart J. 1995; 129: 492-496
        • Kowey P.R.
        • Levine J.H.
        • Herre J.M.
        • Pacifico A.
        • Lindsay B.D.
        • Plumb V.J.
        • Janosik D.L.
        • Kopelman H.A.
        • Scheinman M.M.
        Randomized, double-blind comparison of intravenous amiodarone and bretylium in the treatment of patients with recurrent, hemodynamically destabilizing ventricular tachycardia or fibrillation. The Intravenous Amiodarone Multicenter Investigators Group.
        Circulation. 1995; 92: 3255-3263
        • Scheinman M.M.
        • Levine J.H.
        • Cannom D.S.
        • Friehling T.
        • Kopelman H.A.
        • Chilson D.A.
        • Platia E.V.
        • Wilber D.J.
        • Kowey P.R.
        Dose-ranging study of intravenous amiodarone in patients with life-threatening ventricular tachyarrhythmias. The Intravenous Amiodarone Multicenter Investigators Group.
        Circulation. 1995; 92: 3264-3272
        • Grossman E.
        • Messerli F.H.
        • Grodzicki T.
        • Kowey P.
        Should a moratorium be placed on sublingual nifedipine capsules given for hypertensive emergencies and pseudoemergencies?.
        JAMA. 1996; 276: 1328-1331
        • Kowey P.R.
        • Dalessandro D.A.
        • Herbertson R.
        • Briggs B.
        • Wertan M.A.
        • Rials S.J.
        • Filart R.A.
        • Marinchak R.A.
        Effectiveness of digitalis with or without acebutolol in preventing atrial arrhythmias after coronary artery surgery.
        Am J Cardiol. 1997; 79: 1114-1117
        • Kowey P.R.
        • Marinchak R.A.
        • Rials S.J.
        • Filart R.A.
        Intravenous amiodarone.
        J Am Coll Cardiol. 1997; 29: 1190-1198
        • Brandspiegel H.Z.
        • Marinchak R.A.
        • Rials S.J.
        • Kowey P.R.
        A broken heart.
        Circulation. 1998; 98: 1349
        • Volgman A.S.
        • Carberry P.A.
        • Stambler B.
        • Lewis W.R.
        • Dunn G.H.
        • Perry K.T.
        • Vanderlugt J.T.
        • Kowey P.R.
        Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation.
        J Am Coll Cardiol. 1998; 31: 1414-1419
        • Rials S.J.
        • Xu X.
        • Wu Y.
        • Marinchak R.A.
        • Kowey P.R.
        Regression of LV hypertrophy with captopril normalizes membrane currents in rabbits.
        Am J Physiol. 1998; 275: H1216-1224
        • VanderLugt J.T.
        • Mattioni T.
        • Denker S.
        • Torchiana D.
        • Ahern T.
        • Wakefield L.K.
        • Perry K.T.
        • Kowey P.R.
        Efficacy and safety of ibutilide fumarate for the conversion of atrial arrhythmias after cardiac surgery.
        Circulation. 1999; 100: 369-375
        • Reiffel J.A.
        • Kowey P.R.
        Generic antiarrhythmics are not therapeutically equivalent for the treatment of tachyarrhythmias.
        Am J Cardiol. 2000; 85 (A10): 1151-1153
        • Yan G.X.
        • Kowey P.R.
        ST segment elevation and sudden cardiac death: from the Brugada syndrome to acute myocardial ischemia.
        J Cardiovasc Electrophysiol. 2000; 11: 1330-1332
        • Xu X.
        • Rials S.J.
        • Wu Y.
        • Salata J.J.
        • Liu T.
        • Bharucha D.B.
        • Marinchak R.A.
        • Kowey P.R.
        Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits.
        Circulation. 2001; 103: 1585-1590
        • Meng X.
        • Mojaverian P.
        • Doedée M.
        • Lin E.
        • Weinryb I.
        • Chiang S.T.
        • Kowey P.R.
        Bioavailability of amiodarone tablets administered with and without food in healthy subjects.
        Am J Cardiol. 2001; 87: 432-435
        • Kowey P.R.
        The unnecessary pacemaker controversy revisited.
        Pacing Clin Electrophysiol. 2002; 25: 269-271
        • Medina-Ravell V.A.
        • Lankipalli R.S.
        • Yan G.X.
        • Antzelevitch C.
        • Medina-Malpica N.A.
        • Medina-Malpica O.A.
        • Droogan C.
        • Kowey P.R.
        Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?.
        Circulation. 2003; 107: 740-746
        • Kowey P.R.
        • Kocovic D.Z.
        Cardiology patient pages. Ambulatory electrocardiographic recording.
        Circulation. 2003; 108: e31-e33
        • Yan G.X.
        • Lankipalli R.S.
        • Burke J.F.
        • Musco S.
        • Kowey P.R.
        Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance.
        J Am Coll Cardiol. 2003; 42: 401-409
        • Pepine C.J.
        • Handberg E.M.
        • Cooper-DeHoff R.M.
        • Marks R.G.
        • Kowey P.
        • Messerli F.H.
        • Mancia G.
        • Cangiano J.L.
        • Garcia-Barreto D.
        • Keltai M.
        • Erdine S.
        • Bristol H.A.
        • Kolb H.R.
        • Bakris G.L.
        • Cohen J.D.
        • Parmley W.W.
        • INVEST Investigators
        A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.
        JAMA. 2003; 290: 2805-2816
        • Yan G.X.
        • Joshi A.
        • Guo D.
        • Hlaing T.
        • Martin J.
        • Xu X.
        • Kowey P.R.
        Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia.
        Circulation. 2004; 110: 1036-1041
        • Kowey P.R.
        • Yannicelli D.
        • Amsterdam E.
        COPPA-II Investigators. Effectiveness of oral propafenone for the prevention of atrial fibrillation after coronary artery bypass grafting.
        Am J Cardiol. 2004; 94: 663-665
        • Joshi A.K.
        • Kowey P.R.
        • Prystowsky E.N.
        • Benditt D.G.
        • Cannom D.S.
        • Pratt C.M.
        • McNamara A.
        • Sangrigoli R.M.
        First experience with a Mobile Cardiac Outpatient Telemetry (MCOT) system for the diagnosis and management of cardiac arrhythmia.
        Am J Cardiol. 2005; 95: 878-881
        • Pritchett E.L.
        • Kowey P.
        • Connolly S.
        • Page R.L.
        • Kerr C.
        • Wilkinson W.E.
        • A-COMET-I Investigators
        Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm.
        Am Heart J. 2006; 151: 1043-1049
        • Olshansky B.
        • Kowey P.R.
        • Naccarelli G.V.
        Fast-track training of nonelectrophysiologists to implant defibrillators: is it needed?.
        Pacing Clin Electrophysiol. 2006; 29: 627-631
        • Rothman S.A.
        • Laughlin J.C.
        • Seltzer J.
        • Walia J.S.
        • Baman R.I.
        • Siouffi S.Y.
        • Sangrigoli R.M.
        • Kowey P.R.
        The diagnosis of cardiac arrhythmias: a prospective multi-center randomized study comparing mobile cardiac outpatient telemetry versus standard loop event monitoring.
        J Cardiovasc Electrophysiol. 2007; 18: 241-247
        • Singh B.N.
        • Connolly S.J.
        • Crijns H.J.
        • Roy D.
        • Kowey P.R.
        • Capucci A.
        • Radzik D.
        • Aliot E.M.
        • Hohnloser S.H.
        • EURIDIS and ADONIS Investigators
        Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.
        N Engl J Med. 2007; 357: 987-999
        • Guo D.
        • Young L.
        • Patel C.
        • Jiao Z.
        • Wu Y.
        • Liu T.
        • Kowey P.R.
        • Yan G.X.
        Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit.
        Am J Physiol Heart Circ Physiol. 2008; 295: H97-H104
        • Dorian P.
        • Al-Khalidi H.R.
        • Hohnloser S.H.
        • Brum J.M.
        • Dunnmon P.M.
        • Pratt C.M.
        • Holroyde M.J.
        • Kowey P.
        Shock Inhibition Evaluation with Azimilide Investigators. Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial.
        J Am Coll Cardiol. 2008; 52: 1076-1083
        • Laughlin J.C.
        • Kowey P.R.
        Dronedarone: a new treatment for atrial fibrillation.
        J Cardiovasc Electrophysiol. 2008; 19: 1220-1226
        • Patel C.
        • Yan G.X.
        • Kocovic D.
        • Kowey P.R.
        Should catheter ablation be the preferred therapy for reducing ICD shocks?: Ventricular tachycardia ablation versus drugs for preventing ICD shocks: role of adjuvant antiarrhythmic drug therapy.
        Circ Arrhythm Electrophysiol. 2009; 2 (discussion 712): 705-711
        • Kowey P.R.
        • Dorian P.
        • Mitchell L.B.
        • Pratt C.M.
        • Roy D.
        • Schwartz P.J.
        • Sadowski J.
        • Sobczyk D.
        • Bochenek A.
        • Toft E.
        • Atrial Arrhythmia Conversion Trial Investigators
        Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial.
        Circ Arrhythm Electrophysiol. 2009; 2: 652-659
        • Al-Khatib S.M.
        • Calkins H.
        • Eloff B.C.
        • Packer D.L.
        • Ellenbogen K.A.
        • Hammill S.C.
        • Natale A.
        • Page R.L.
        • Prystowsky E.
        • Jackman W.M.
        • Stevenson W.G.
        • Waldo A.L.
        • Wilber D.
        • Kowey P.
        • Yaross M.S.
        • Mark D.B.
        • Reiffel J.
        • Finkle J.K.
        • Marinac-Dabic D.
        • Pinnow E.
        • Sager P.
        • Sedrakyan A.
        • Canos D.
        • Gross T.
        • Berliner E.
        • Krucoff M.W.
        Planning the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a Collaborative Pan-Stakeholder Critical Path Registry Model: a Cardiac Safety Research Consortium “Incubator” Think Tank.
        Am Heart J. 2010; 159: 17-24
        • Kowey P.R.
        • Reiffel J.A.
        • Ellenbogen K.A.
        • Naccarelli G.V.
        • Pratt C.M.
        Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: a randomized controlled trial.
        JAMA. 2010; 304: 2363-2372
        • Kowey P.R.
        How much has malpractice litigation altered the care of cardiac rhythm patients?.
        J Cardiovasc Electrophysiol. 2011; 22: 488-489
        • Kowey P.R.
        A piece of my mind. The silent majority.
        JAMA. 2011; 306: 18-19
        • Kowey P.R.
        • Crijns H.J.
        • Aliot E.M.
        • Capucci A.
        • Kulakowski P.
        • Radzik D.
        • Roy D.
        • Connolly S.J.
        • Hohnloser S.H.
        • ALPHEE Study Investigators
        Efficacy and safety of celivarone, with amiodarone as calibrator, in patients with an implantable cardioverter-defibrillator for prevention of implantable cardioverter-defibrillator interventions or death: the ALPHEE study.
        Circulation. 2011; 124: 2649-2660
        • Kowey P.R.
        • Naccarelli G.V.
        The Food and Drug Administration decision not to approve the 110 mg dose of dabigatran: give us a way out.
        Am J Med. 2012; 125: 732