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The Effect of Statin on the Incidence of Diabetes Mellitus

      Navarese et al recently reported a meta-analysis of randomized controlled trials concerning the effect of various types and doses of statins on new-onset diabetes mellitus (DM). The authors concluded that pravastatin 40 mg/day was associated with the lowest risk for new-onset DM compared with placebo.
      • Navarese E.P.
      • Buffon A.
      • Andreotti F.
      • Kozinski M.
      • Welton N.
      • Fabiszak T.
      • Caputo S.
      • Grzesk G.
      • Kubica A.
      • Swiatkiewicz I.
      • Sukiennik A.
      • Kelm M.
      • De Servi S.
      • Kubica J.
      Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus.
      Carter et al reported a population-based cohort study concerning the effect of various types and doses of statins on new-onset DM by setting pravastatin as a control. Although the clinical evidence was weaker than that in randomized controlled trials, these authors concluded that higher-potency statins might be contributed to the increase of new-onset DM.
      • Carter A.A.
      • Gomes T.
      • Camacho X.
      • Juurlink D.N.
      • Shah B.R.
      • Mamdani M.M.
      Risk of incident diabetes among patients treated with statins: population based study.
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      References

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      Linked Article

      • Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus
        American Journal of CardiologyVol. 111Issue 8
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          Recent reports indicate that statins are associated with an increased risk for new-onset diabetes mellitus (DM) compared with placebo and that this relation is dose dependent. The aim of this study was to perform a comprehensive network meta-analysis of randomized controlled trials (RCTs) investigating the impact of different types and doses of statins on new-onset DM. RCTs comparing different types and doses of statins with placebo were searched for using the MEDLINE, Embase, and Cochrane databases.
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