Increasing adiposity increases the risk for left ventricular (LV) hypertrophy. Adipokines
are hormone-like substances from adipose tissue that influence several metabolic pathways
relevant to LV hypertrophy. Data were obtained from participants enrolled in the Multi-Ethnic
Study of Atherosclerosis (MESA) who underwent magnetic resonance imaging of the heart
and who also had fasting venous blood assayed for 4 distinct adipokines (adiponectin,
leptin, tumor necrosis factor-α, and resistin). One-thousand four hundred sixty four
MESA participants had complete data. The mean age was 61.5 years, the mean body mass
index was 27.6 kg/m2, and 49% were women. With adjustment for age, gender, race, height, and weight, multivariate
linear regression modeling revealed that a 1-SD increment in leptin was significantly
associated with smaller LV mass (ß: −4.66% predicted, p <0.01), LV volume (−5.87%
predicted, p <0.01), stroke volume (−3.23 ml, p <0.01), and cardiac output (−120 ml/min,
p = 0.01) as well as a lower odds ratio for the presence of LV hypertrophy (odds ratio
0.65, p <0.01), but a higher ejection fraction (0.44%, p = 0.05). Additional adjustment
for the traditional cardiovascular disease risk factors, insulin resistance, physical
activity, education, income, inflammatory biomarkers, other selected adipokines, and
pericardial fat did not materially change the magnitude or significance of the associations.
The associations between the other adipokines and LV structure and function were inconsistent
and largely nonsignificant. In conclusion, the results indicate that higher levels
of leptin are associated with more favorable values of several measures of LV structure
and function.
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Article Info
Publication History
Published online: May 28, 2013
Accepted:
April 19,
2013
Received in revised form:
April 19,
2013
Received:
February 26,
2013
Footnotes
This research was supported by a grant R01-HL-088451 and contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland .
See page 730 for disclosure information.
Identification
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Published by Elsevier Inc.
