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Predictors of Left Ventricular Remodeling After Surgical Repair or Replacement for Pure Severe Mitral Regurgitation Caused by Leaflet Prolapse

      We sought to determine whether preoperative baseline echocardiographic analysis and the type of surgical procedure are predictive of the magnitude and timing of postoperative left ventricular (LV) remodeling in patients undergoing valve surgery for pure severe mitral regurgitation (MR) secondary to leaflet prolapse. Seventy-two consecutive patients without coronary artery disease undergoing valve repair (MVr; n = 42) or replacement (MVR; n = 30) underwent preoperative, early (1 to 2 days) and late postoperative (4.5 ± 2.5 and 18 ± 8.0 months) echocardiography. Patients were categorized according to their baseline LV ejection fraction (EF) (Group 1: EF ≥60%, Group 2: EF = 50% to 59%, Group 3: EF <50%). Preservation of the subvalvular apparatus was achieved in most patients undergoing MV replacement (87%). Over a median follow-up period of 450 days, LVEF changed as follows: Group 1: 63% ± 2% to 60% ± 3% (p <0.0001); Group 2: 55% ± 3% to 52% ± 6% (p <0.0001); Group 3: 43% ± 4% to 42% ± 5% (p <0.01). Two-thirds of the observed changes in LV diameters and volumes occurred in the first 6 months. Preoperative LVEF was the best predictor of postoperative LVEF ≥60% (odds ratio 1.50, 95% confidence interval, 1.25 to 1.97; p <0.0001). No significant difference was found in LV remodeling parameters between patients undergoing MVr and MVR. In conclusion, patients with pure severe MR due to valve prolapse LVEF remained normal after surgery only in patients with baseline LVEF ≥60%. MVR with subvalvular preservation was associated with similar postoperative remodeling as MVr.
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