We are deluged by reports of the “rare” takotsubo syndrome (TTS) (as of November 15,
2012, there were 1,478 entries in PubMed using the search term “takotsubo”
1
), and while the reporting goes on, the pathophysiologic underpinning of the condition
become muddier and muddier. The objective of this note is to gain the attention of
clinicians who are destined to manage patients presenting with suspected TTS. Although
the diagnosis of TTS is eventually made after a few hours to days of ambivalence in
its differentiation from acute coronary syndromes (ACSs), we miss the opportunity
to make a dent in our understanding of its pathophysiology, because of the varied
and temporally haphazard application of our diagnostic techniques. We need to change
our modus operandi.National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health. Available at: http://www.ncbi.nlm.nih.gov/pubmed?term=takotsubo. Accessed November 15, 2012.
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References
National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health. Available at: http://www.ncbi.nlm.nih.gov/pubmed?term=takotsubo. Accessed November 15, 2012.
- Neurohumoral features of myocardial stunning due to sudden emotional stress.N Engl J Med. 2005; 352: 539-548
- Takotsubo syndrome.Coron Artery Dis. 2011; 22: 206-214
- High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of takotsubo cardiomyopathy.Circulation. 2012; 126: 697-706
- Electrocardiogram in myocardial edema due to takotsubo syndrome.J Electrocardiol. 2012; 45: 795-796
Article info
Publication history
Received:
November 15,
2012
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© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
