Side Effects of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists: Are We Facing a New Syndrome

      Knowledge of the side effects of angiotensin-converting-enzyme (ACE) inhibitors is a matter of current discussion. Further to the recent Readers' Comment by Roberts et al,
      • Roberts J.R.
      • Lee J.
      • Marthers D.
      Angiotensin-converting enzyme (ACE) inhibitor angioedema: the silent epidemic.
      some adverse drug reactions (ADRs) caused by ACE inhibitors are likely to be found by allergists, but ADRs to angiotensin II receptors blockers (ARBs) may also be found. The number of symptoms associated with these ADRs might allow them to be considered a new “syndrome.”
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      Linked Article

      • Angiotensin-Converting Enzyme (ACE) Inhibitor Angioedema: The Silent Epidemic
        American Journal of CardiologyVol. 109Issue 5
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          An idiosyncratic reaction to commonly prescribed angiotensin-converting enzyme (ACE) inhibitors may require tracheal intubation or a surgical airway for impending respiratory compromise due to massive tongue swelling (Figure 1).1 This is not an immunoglobulin E–mediated allergic reaction, and treatment with diphenhydramine, methylprednisolone, and epinephrine will not reverse the pathology. There are no effective pharmacologic interventions to reverse or slow this form of angioedema, although the use of fresh frozen plasma has been suggested.
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