Advertisement

The Editor's Roundtable: Advances in Stem Cell Therapy for Treatment of Cardiovascular Disease

      This article is supported by a grant from the Okyanos Heart Institute, Freeport, The Bahamas.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Strauer B.E.
        • Brehm M.
        • Zeus T.
        • Kostering M.
        • Hernandez A.
        • Sorg R.V.
        • Kogler G.
        • Wernet P.
        Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans.
        Circulation. 2002; 106: 1913-1918
        • Perin E.C.
        • Dohmann H.F.
        • Borojevic R.
        • Silva S.A.
        • Sousa A.L.
        • Mesquita C.T.
        • Rossi M.I.
        • Carvalho A.C.
        • Dutra H.S.
        • Dohmann H.J.
        • Silva G.V.
        • Belem L.
        • Vivacqua R.
        • Rangel F.O.
        • Esporcatte R.
        • Geng Y.J.
        • Vaughn W.K.
        • Assad J.A.
        • Mesquita E.T.
        • Willerson J.T.
        Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure.
        Circulation. 2003; 107: 2294-2302
        • Foldes G.
        • Harding S.E.
        Stem Cell Therapy to Treat Heart Failure.
        in: 2nd ed. Elsevier, New York2011: 407-423
        • Strauer B.-E.
        • Steinhoff G.
        10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart.
        J Am Coll Cardiol. 2011; 58: 1095-1104
        • Heldman A.W.
        • Zambrano J.P.
        • Hare J.
        Cell therapy for heart disease. Where are we in 2011?.
        J Am Coll Cardiol. 2011; 57: 466-468
        • Blum B.
        • Benvenisty N.
        The tumorigenicity of human embryonic stem cells.
        Adv Cancer Res. 2008; 100: 133-158
        • Aggarwal S.
        • Pittenger M.F.
        Human mesenchymal stem cells moderate allogenic immune cell responses.
        Blood. 2005; 105: 1815-1822
        • Makkar R.R.
        • Smith R.R.
        • Cheng K.
        • Malliaras K.
        • Thomson L.E.J.
        • Berman D.
        • Czer L.S.C.
        • Marban L.
        • Mendizabal A.
        • Johnston
        • Russell S.D.
        • Schuleri K.H.
        • Lardo A.C.
        • Gerstenblith G.
        • Marbán MD, E.
        Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.
        Lancet. 2012; 379: 895-904
        • Davis D.R.
        • Smith R.R.
        • Marbán E.
        Human cardiospheres are a source of stem cells with cardiomyogenic potential.
        Stem Cells. 2010; 28: 903-904
        • Bolli R.
        • Chugh A.R.
        • D'Amario D.
        • Laughran J.H.
        • Stoddard M.F.
        • Ikram S.
        • Beache G.M.
        • Wagner S.G.
        • Leri A.
        • Hosoda T.
        • Sanada F.
        • Elmore J.B.
        • Goichberg P.
        • Cappetta D.
        • Solakhi N.K.
        • Fahsah I.
        • Rokosh D.G.
        • Slaughter M.S.
        • Kajusta J.
        • Anversa P.
        Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomized phase 1 trial.
        Lancet. 2011; 378: 1847-1857
        • Small E.M.
        • Thatcher J.E.
        • Sutherland L.B.
        • Kinoshita H.
        • Gerard R.D.
        • Richardson J.A.
        • DiMaio J.M.
        • Sadek H.
        • Kuwahara K.
        • Olson E.N.
        Myocardin-related transcription factor-A controls myofibroblast activation and fibrosis in response to myocardial infarction.
        Circ Res. 2010; 107: 294-304
        • Beltrami A.P.
        • Barlucchi L.
        • Torella D.
        • Baker M.
        • Limana F.
        • Chimenti S.
        • Kasahara H.
        • Rota M.
        • Musso E.
        • Urbanek K.
        • Leri A.
        • Kajstura J.
        • Nadal-Ginard B.
        • Anversa P.
        Adult cardiac stem cells are multipotent and support myocardial regeneration.
        Cell. 2003; 114: 763-776
        • Askari A.T.
        • Unzek S.
        • Popovic Z.B.
        • Goldman C.K.
        • Forudi F.
        • Kiedrowski M.
        • Rovner A.
        • Ellis S.G.
        • Thomas J.D.
        • DiCorleto P.E.
        • Topol E.J.
        • Penn M.S.
        Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.
        Lancet. 2003; 362: 697-703
        • Menon V.
        • Pearte C.A.
        • Buller C.E.
        • Steg G.
        • Forman S.A.
        • White H.D.
        • Marino P.N.
        • Katritsis D.G.
        • Caramori P.
        • Lasevitch R.
        • Loboz-Grudzien K.
        • Zurakowski A.
        • Lamas G.A.
        • Hochman J.S.
        Lack of benefit from percutaneous intervention of persistently occluded infarct arteries after the acute phase of myocardial infarction is time independent: insights from Occluded Artery Trial.
        Eur Heart J. 2009; 30: 183-191
        • Perin E.C.
        • Willerson J.T.
        • Pepine C.J.
        • Henry T.D.
        • Ellis S.G.
        • Zhao D.X.
        • Silva G.V.
        • Lai D.
        • Thomas J.D.
        • Kronenberg M.W.
        • Martin A.D.
        • Anderson R.D.
        • Traverse J.H.
        • Penn M.S.
        • Anwaruddin S.
        • Hatzopoulos A.K.
        • Gee A.P.
        • Taylor D.A.
        • Cogle C.R.
        • Smith D.
        • Westbrook L.
        • Handberg E.
        • Olson R.E.
        • Geither C.
        • Bowman S.
        • Francescon J.
        • Baraniuk S.
        • Piller L.B.
        • Simpson L.M.
        • Loghin C.
        • Aguilar D.
        • Richman S.
        • Zierold C.
        • Bettencourt J.
        • Sayre S.L.
        • Vojvodic R.W.
        • Skarlatos S.I.
        • Gordon D.J.
        • Ebert R.F.
        • Kwak M.
        • Moyé L.A.
        • Simari R.D.
        • Cardiovascular Cell Therapy Research Network
        Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial.
        JAMA. 2012; 307: 1717-1726
        • Tan J.
        • Wu W.
        • Xu X.
        • Liao L.
        • Zheng F.
        • Messinger S.
        • Sun X.
        • Chen J.
        • Yang S.
        • Cai J.
        • Gao X.
        • Pileggi A.
        • Ricordi C.
        Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
        JAMA. 2012; 307: 1169-1177
        • Wang W.
        • Lang J.K.
        • Suzuki G.
        • Canty J.M.
        • Cimato T.
        Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart.
        PLoS One. 2011; 6: e24868
        • Menasche P.
        Stem cell therapy for heart failure.
        Circulation. 2009; 119: 2735-2740
        • Hare J.M.
        • Traverse J.H.
        • Henry T.D.
        • Dib N.
        • Strumpf R.K.
        • Schulman S.P.
        • Gerstenblith G.
        • DeMaria A.N.
        • Denktas A.E.
        • Gammon R.S.
        • Hermiller Jr, J.B.
        • Reisman M.A.
        • Schaer G.L.
        • Sherman W.
        A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.
        J Am Coll Cardiol. 2009; 54: 2277-2286
        • Stewart S.
        • MacIntyre K.
        • Hole D.J.
        • Capewell S.
        • McMurray J.J.V.
        More “malignant” than cancer?.
        Eur Heart Fail. 2001; 3: 315-322