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PETER LIBBY, MD: A Conversation With the Editor

      Peter Libby was born in Berkeley, California, on February 13, 1947, and grew up in that city as well. He graduated in 1969 from the University of California (UC), Berkeley with a bachelor's degree in biochemistry and French literature, and earned his medical degree in 1973 from UC, San Diego. He trained in internal medicine and in cardiovascular diseases at the Peter Bent Brigham Hospital (now Brigham and Women's Hospital [BWH]) in Boston. During medical school, he was active in research, and continued this during his residency and fellowship. After completing a clinical/research fellowship in medicine, he became an assistant professor of medicine at Tufts University School of Medicine, and established a basic cardiovascular research laboratory there. Just as he was being promoted to full professor of medicine and physiology at Tufts in 1990, he was asked to return to BWH—and did—as director of the vascular medicine and atherosclerosis unit of the cardiovascular division in the department of medicine. In 1998, he became chief of cardiovascular medicine at BWH, and has remained in that position ever since. His research has flourished during the past 30 years, and he has led the investigation of the relation between atherosclerosis and inflammation—resulting in the publication of >300 articles in peer-reviewed medical journals. He also is an editor of Braunwald's Heart Disease. Dr. Libby is a popular speaker and has been a visiting professor at prominent universities in numerous countries. He and his lovely wife, Beryl Benacerraf—also a full professor at Harvard Medical School—are the parents of 2 very successful children. Moreover, Dr. Libby is a pleasure to be around.
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      PL'S Best Publications as Selected by PL

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        • Libby P.
        • Goldberg A.L.
        Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles.
        Science. 1978; 199: 534-536
        • Libby P.
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        Am J Physiol Endocrinol Metab. 1979; 237: E35-E39
        • Libby P.
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        Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.
        Arterioscler Thromb. 1991; 11: 1223-1230
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        Atherogenic diets enhance endotoxin-stimulated interleukin-1 and tumor necrosis factor gene expression in rabbit aortae.
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        Am J Pathol. 1992; 140: 301-316
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        Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury.
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        Interaction of the allogeneic state and hypercholesterolemia in arterial lesion formation in experimental cardiac allografts.
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        Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.
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        Proc Natl Acad Sci U S A. 1995; 92: 402-406
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        • Mach F.
        • Sauty A.
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        • Sukhova G.K.
        • Grubb A.
        • Ducharme A.
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        Cystatin C deficiency in human atherosclerosis and aortic aneurysms.
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        • Libby P.
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        The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques.
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        • Sukhova G.K.
        • Shimizu K.
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        • Libby P.
        Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice.
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        • Marx N.
        • Mackman N.
        • Schönbeck U.
        • Yilmaz N.
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        • Libby P.
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        PPARalpha activators inhibit tissue factor expression and activity in human monocytes.
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        • Libby P.
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        • Rabkin E.
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        • Gerdes N.
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        • Libby P.
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        T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm.
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        • Marx N.
        • Kehrle B.
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        • Rabkin E.
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        Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
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        Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol.
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        • Maron R.
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        • Faria A.M.
        • Hoffmann E.
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        • Takayama K.
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        • Comander J.
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        • Libby P.
        Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor.
        J Biol Chem. 2002; 277: 44147-44154
        • Sukhova G.K.
        • Zhang Y.
        • Pan J.H.
        • Wada Y.
        • Yamamoto T.
        • Naito M.
        • Kodama T.
        • Tsimikas S.
        • Witztum J.L.
        • Lu M.L.
        • Sakara Y.
        • Chin M.T.
        • Libby P.
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        Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice.
        J Clin Invest. 2003; 111: 897-906
        • Krettek A.
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        • Libby P.
        Elastogenesis in human arterial disease: A role for macrophages in disordered elastin synthesis.
        Arterioscler Thromb Vasc Biol. 2003; 23: 582-587
        • Dollery C.M.
        • Owen C.A.
        • Sukhova G.K.
        • Krettek A.
        • Shapiro S.D.
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        Neutrophil elastase in human atherosclerotic plaques: production by macrophages.
        Circulation. 2003; 107: 2829-2836
        • Pan J.H.
        • Sukhova G.K.
        • Yang J.T.
        • Wang B.
        • Xie T.
        • Fu H.
        • Zhang Y.
        • Satoskar A.R.
        • David J.R.
        • Metz C.N.
        • Bucala R.
        • Fang K.
        • Simon D.I.
        • Chapman H.A.
        • Libby P.
        • Shi G.P.
        Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.
        Circulation. 2004; 109: 3149-3153
        • Sugiyama S.
        • Kugiyama K.
        • Aikawa M.
        • Nakamura S.
        • Ogawa H.
        • Libby P.
        Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis.
        Arterioscler Thromb Vasc Biol. 2004; 24: 1309-1314
        • Shimizu K.
        • Shichiri M.
        • Libby P.
        • Lee R.T.
        • Mitchell R.N.
        Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas.
        J Clin Invest. 2004; 114: 300-308
        • Fukumoto Y.
        • Deguchi J.O.
        • Libby P.
        • Rabkin-Aikawa E.
        • Sakata Y.
        • Chin M.T.
        • Hill C.C.
        • Lawler P.R.
        • Varo N.
        • Schoen F.J.
        • Krane S.M.
        • Aikawa M.
        Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.
        Circulation. 2004; 110: 1953-1959
        • Sukhova G.K.
        • Wang B.
        • Libby P.
        • Pan J.H.
        • Zhang Y.
        • Grubb A.
        • Fang K.
        • Chapman H.A.
        • Shi G.P.
        Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.
        Circ Res. 2005; 96: 368-375
        • Deguchi J.O.
        • Aikawa E.
        • Libby P.
        • Vachon J.R.
        • Inada M.
        • Krane S.M.
        • Whittaker P.
        • Aikawa M.
        Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.
        Circulation. 2005; 112: 2708-2715
        • Liu J.
        • Sukhova G.K.
        • Yang J.T.
        • Sun J.
        • Ma L.
        • Ren A.
        • Xu W.H.
        • Dolganov G.M.
        • Hu C.
        • Libby P.
        • Shi G.P.
        Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
        Atherosclerosis. 2006; 184: 302-311
        • Takayama K.
        • Sukhova G.K.
        • Chin M.T.
        • Libby P.
        A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling.
        Circ Res. 2006; 98: 499-504
        • Healy A.M.
        • Pickard M.D.
        • Pradhan A.D.
        • Wang Y.
        • Chen Z.
        • Croce K.
        • Sakuma M.
        • Shi C.
        • Zago A.C.
        • Garasic J.
        • Damokosh A.I.
        • Dowie T.L.
        • Poisson L.
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        • Libby P.
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        • Simon D.I.
        Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events.
        Circulation. 2006; 113: 2278-2284
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