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Eugene Braunwald, MD and the Early Years of Hypertrophic Cardiomyopathy: A Conversation With Dr. Barry J. Maron

      There is some uncertainty, and even controversy, as to when hypertrophic cardiomyopathy was first recognized. Dating back to 1868, there are autopsy-based case reports from France, Germany, and the United Kingdom composed of 1 or a few patients who appear to have died suddenly of a disease consistent in its features with hypertrophic cardiomyopathy.
      • Vulpian A.
      Contribution a l'etude des retrecissements de l'orifice ventriculo-aortique.
      • Liouville H.
      Rétrécissement cardiaque sous aortique.
      • Hallopeau M.
      Rétrécissement ventricuo-aortique.
      • Whittle C.H.
      “Idiopathic” hypertrophy of the heart in a young man.
      • Evans W.
      Familial cardiomegaly.
      • Davies L.G.
      A familial heart disease.
      • Campbell M.
      • Turner-Warwick M.
      Two more families with cardiomegaly.
      • Braunwald E.
      Hypertrophic cardiomyopathy: the early years.
      The 1959 and 1960 reports from London of Brock (clinical)
      • Brock R.
      Functional obstruction of the left ventricle; acquired aortic subvalvar stenosis.
      • Brock R.
      Functional obstruction of the left ventricle (acquired aortic subvalvar stenosis).
      and Teare (pathologic)
      • Teare D.
      Asymmetrical hypertrophy of the heart in young adults.
      are generally regarded as the first contemporary descriptions of hypertrophic cardiomyopathy. However, it is appropriate at this time to reflect on how and why this important disease was transformed from the subject of a few anecdotal case reports into a robust and treatable clinical entity ultimately regarded as a common genetic heart disease and the most frequent cause of sudden death in young individuals (including trained athletes).
      • Maron B.J.
      Hypertrophic cardiomyopathy: a systematic review.
      • Maron B.J.
      • McKenna W.J.
      • Danielson G.K.
      • Kappenberger L.J.
      • Kuhn H.J.
      • Seidman C.E.
      • Shah P.M.
      • Spencer W.H.
      • Spirito P.
      • ten Cate F.J.
      • Wigle E.D.
      American College of Cardiology/European Society of Cardiology Clinical expert consensus document on hypertrophic cardiomyopathy A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines Committee to Develop an Expert Consensus Document on Hypertrophic Cardiomyopathy.
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