PAUL A. GRAYBURN, MD, on Percutaneous Mitral Repair With the MitraClip™ Device: A Conversation With the Editor

  • Paul A. Grayburn
    Corresponding author: Tel: 214-820-7500; fax: 214-820-7533
    Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas

    Department of Internal Medicine (Cardiology), Baylor University Medical Center, Dallas, Texas
    Search for articles by this author
  • William C. Roberts
    Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas

    Department of Internal Medicine (Cardiology), Baylor University Medical Center, Dallas, Texas

    Department of Pathology, Baylor University Medical Center, Dallas, Texas
    Search for articles by this author
      Paul Grayburn did his general cardiology fellowship under the tutelage of Dr. Anthony N. DeMaria at the University of Kentucky from 1984 to 1986, followed by a year of interventional cardiology training with Dr. David C. Booth. In 1988, he was recruited to the University of Texas Southwestern Medical School by Dr. James T. Willerson, where he served on the faculty for 15 years. During that time, he was director of the echocardiography laboratories at the University of Texas Southwestern and chief of cardiology at the Dallas Veterans Affairs Medical Center, where he also practiced interventional cardiology. In 2002, Dr. Grayburn moved to Baylor University Medical Center to accept the Paul J. Thomas Chair in Cardiology Research and Education. He has published more than 260 articles, mainly in peer-reviewed medical journals. He has served as an associate editor of The American Journal of Cardiology since 1997. He is on the editorial boards of Circulation, the Journal of the American College of Cardiology: Cardiovascular Imaging, and Heart. Dr. Grayburn currently serves on the Publications Committee for the Endovascular Edge-to-Edge Repair Study (EVEREST) II and the Core Lab Committee and Steering Committee of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. He has held a National Institutes of Health K24 grant for mentoring junior faculty members and an R01 grant, “Functional Mitral Regurgitation in Ischemic Cardiomyopathy,” for 3-dimensional transesophageal echocardiographic evaluation of the mechanisms of functional mitral regurgitation (MR) in the STICH trial. He has served on multiple committees for the American Society of Echocardiography, including the Task Force for Quantitation of Valvular Regurgitation. He is currently the principal investigator for the MitraClip (Abbott Laboratories, Abbott Park, Illinois) studies at Baylor Health Care System and co-investigator for the Cardiothoracic Surgery Network Trials on MR. Dr. Grayburn's background in interventional cardiology and echocardiography, including intraoperative transesophageal echocardiography during surgical mitral valve repair, give him a unique insight into percutaneous mitral valve therapies.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Fucci C.
        • Sandrelli L.
        • Pardini A.
        • Torracca L.
        • Ferrari M.
        • Alfieri O.
        Improved results with mitral valve repair using new surgical techniques.
        Eur J Cardiothorac Surg. 1995; 9: 621-626
        • Feldman T.
        • Foster E.
        • Glower D.G.
        • Kar S.
        • Rinaldi M.J.
        • Fail P.S.
        • Smalling R.W.
        • Siegel R.
        • Rose G.A.
        • Engeron E.
        • Loghin C.
        • Trento A.
        • Skipper E.R.
        • Fudge T.
        • Letsou G.V.
        • Massaro J.M.
        • Mauri L.
        • EVEREST II Investigators
        Percutaneous repair or surgery for mitral regurgitation.
        N Engl J Med. 2011; 364: 1395-1406
        • Feldman T.
        • Kar S.
        • Rinaldi M.
        • Fail P.
        • Hermiller J.
        • Smalling R.
        • Whitlow P.L.
        • Gray W.
        • Low R.
        • Herrmann H.C.
        • Lim S.
        • Foster E.
        • Glower D.
        • EVEREST Investigators
        Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge Repair Study) cohort.
        J Am Coll Cardiol. 2009; 54: 686-694
        • Argenziano M.
        • Skipper E.
        • Heimansohn D.
        • Letsou G.V.
        • Woo Y.J.
        • Kron I.
        • Alexander J.
        • Cleveland J.
        • Kong B.
        • Davidson M.
        • Vassiliades T.
        • Krieger K.
        • Sako E.
        • Tibi P.
        • Galloway A.
        • Foster E.
        • Feldman T.
        • Glower D.
        • EVEREST Investigators
        Surgical revision after percutaneous mitral repair with the MitraClip device.
        Ann Thorac Surg. 2010; 89: 72-80
        • Zoghbi W.A.
        • Enriquez-Sarano M.
        • Foster E.
        • Grayburn P.A.
        • Kraft C.D.
        • Levine R.A.
        • Nihoyannopoulos P.
        • Otto C.M.
        • Quinones M.A.
        • Rakowski H.
        • Stewart W.J.
        • Waggoner A.
        • Weissman N.J.
        Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography.
        J Am Soc Echocardiogr. 2003; 16: 777-802
        • Grayburn P.A.
        • Bhella P.
        Grading severity of mitral regurgitation by echocardiography; science or art?.
        JACC Cardiovasc Imaging. 2010; 3: 244-246
        • Ling L.H.
        • Enriquez-Sarano M.
        • Seward J.B.
        • Tajik A.J.
        • Schaff H.V.
        • Bailey K.R.
        • Frye R.L.
        Clinical outcome of mitral regurgitation due to flail leaflet.
        N Engl J Med. 1996; 335: 1417-1423
        • Grigioni F.
        • Tribouilloy C.
        • Avierinos J.F.
        • Barbieri A.
        • Ferlito M.
        • Trojette F.
        • Tafanelli L.
        • Branzi A.
        • Szymanski C.
        • Habib G.
        • Modena M.G.
        • Enriquez-Sarano M.
        • MIDA Investigators
        Outcomes in mitral regurgitation due to flail leaflets: a multicenter European study.
        JACC Cardiovasc Imaging. 2008; 1: 133-141