Metabolic syndrome (MS) and atrial fibrillation (AF) are associated with increased
cardiovascular disease morbidity and mortality. This analysis evaluated the association
between MS and AF in the REasons for Geographic and Racial Differences in Stroke (REGARDS)
study. MS was defined using criteria recommended in the joint interim statement from
several international societies. AF was defined by electrocardiogram (ECG) and/or
self-report and by ECG alone. In patients with 0, 1, 2, 3, 4, and 5 MS components,
prevalences of AF by ECG and/or self-report were 5.5%, 7.7%, 8.2%, 9.2%, 9.6%, and
11.5%, respectively (p for trend <0.001). After multivariable adjustment, each MS
component except serum triglycerides was significantly associated with AF. The multivariable-adjusted
odds ratio for AF, defined by ECG and/or or self-reported history, comparing those
with to those without MS was 1.20 (95% confidence interval 1.10 to 1.29). Results
were consistent when AF was defined by ECG alone (odds ratio 1.15, 95% confidence
interval 0.92 to 1.39). In conclusion, MS is associated with an increased prevalence
of AF. Further studies investigating a potential mechanism for this excess risk are
warranted.
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Article info
Publication history
Published online: May 02, 2011
Accepted:
March 9,
2011
Received in revised form:
March 9,
2011
Received:
November 24,
2010
Footnotes
This research project is supported by a cooperative agreement (U01 NS041588) from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, Department of Health and Human Services. Additional funding was provided by an investigator-initiated grant-in-aid from Amgen Corporation, Thousand Oaks, California. Dr. Brown is supported by grant 5KL2 RR025776-02 from UAB Center for Clinical and Translational Science with funding from the NIH National Center for Research Resources.
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© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
