We aimed to determine whether polymorphisms in chromosome 4q25 are associated with
postoperative atrial fibrillation (AF), long-term AF, postoperative or long-term stroke,
and long-term survival after coronary artery bypass grafting. We performed genotyping
for rs2200733 and rs10033464 in white participants (n = 1,166) from the TexGen genetic
registry. The development of postoperative or long-term AF, postoperative or long-term
stroke, and long-term mortality were ascertained. Both rs2200733 and rs10033464 were
associated with postoperative AF (odds ratio [OR] 1.41, 95% confidence interval [CI]
1.04 to 1.91, and OR 1.47, 95% CI 1.05 to 2.06, respectively). Carriers of the risk
allele (T) had an increased risk of postoperative AF with preoperative β blocker (BB)
(for rs2200733, OR 1.47, 95% CI 1.004 to 2.16 for those taking a BB, and OR 1.13,
95% CI 0.73 to 1.73 for those not taking a BB; for rs10033464, OR 1.89, 95% CI 1.22
to 2.93 for those taking preoperative a BB, and OR 1.04, 95% CI 0.65 to 1.65 for those
not taking a BB). Both rs2200733 and rs10033464 were also associated with long-term
AF (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to
1.66, respectively). Carriers of rs2200733 had increased long-term mortality (hazard
ratio 1.57, 95% CI 1.10 to 2.24). These variants were not associated with postoperative
or long-term stroke. In conclusion, variants in 4q25 are associated with an increased
risk of postoperative or long-term AF and, possibly, mortality in whites undergoing
coronary artery bypass grafting, and could potentially affect the choice of therapy
used to decrease postoperative AF.
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Article info
Publication history
Published online: March 18, 2011
Accepted:
January 18,
2011
Received:
December 10,
2010
Footnotes
This work was supported by grant 08RDM003 from the Roderick D. MacDonald research fund, St. Luke's Episcopal Hospital (Houston, Texas). Dr. Virani was supported by Career Development Award CDA-09-028 from the Department of Veterans Affairs Health Services Research and Development Service (Washington, DC). This work was also supported by grants National Institutes of Health UL1 RR024148 and 1R01NR010235-01A1 through the TexGen Foundation (Houston, Texas) and funded by the National Institute of Nursing Research (Washington, DC).
The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
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