The Editor's Roundtable: Contrast Agents and Risk for Contrast-Induced Nephropathy

  • Vincent E. Friedewald
    Corresponding author: Tel: 512-264-1611; fax: 512-264-8939
    Associate Editor, The American Journal of Cardiology, Clinical Professor, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas, USA, Research Professor, College of Science, University of Notre Dame, Notre Dame, Indiana, USA and Adjunct Senior Research Professor, Indiana University School of Medicine–South Bend, South Bend, Indiana
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  • Stanley Goldfarb
    Professor of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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  • Warren K. Laskey
    Professor of Medicine and Chief, Division of Cardiology, University of New Mexico School of Medicine, Albuquerque, New Mexico
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  • George W. Vetrovec
    Kimmerling Professor of Medicine and Director, Adult Cardiac Catheterization Laboratory, Virginia Commonwealth University, Richmond, Virginia
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  • William C. Roberts
    Editor-in-Chief, The American Journal of Cardiology and Baylor University Medical Center Proceedings, Executive Director, Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas, and Dean, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas, Texas
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      This discussion is supported by an educational grant from GE Healthcare, Ltd., Chalfont St Giles, United Kingdom.
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        • Kushner F.G.
        • Hand M.
        • Smith Jr, S.C.
        • King III, S.B.
        • Anderson J.L.
        • Antman E.M.
        • Bailey S.R.
        • Bates E.R.
        • Blankenship J.C.
        • Casey Jr, D.E.
        • Green L.A.
        • Hochman J.S.
        • Jacobs A.K.
        • Krumholz H.M.
        • Morrison D.A.
        • Ornato J.P.
        • Pearle D.L.
        • Peterson E.D.
        • Sloan M.A.
        • Whitlow P.L.
        • Williams D.O.
        American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
        Circulation. 2009; 120: 2271-2306
        • National Kidney Foundation
        K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
        Am J Kidney Dis. 2002; 39: S1-S266
        • Levey A.S.
        • Bosch J.P.
        • Lewis J.B.
        • Greene T.
        • Rogers N.
        • Roth D.
        • Modification of Diet in Renal Disease Study Group
        A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation.
        Ann Intern Med. 1999; 130: 461-470
        • Botev R.
        • Mallié J.-P.
        • Couchoud C.
        • Schück O.
        • Fauvel J.-P.
        • Wetzels J.F.M.
        • Lee N.
        • De Santo N.G.
        • Cirillo M.
        Estimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease Formulas compared to renal insulin clearance.
        Clin J Am Soc Nephrol. 2009; 4: 899-906
        • Laskey W.
        • Aspelin P.
        • Davidson C.
        • Rudnick M.
        • Aubry P.
        • Kumar S.
        • Gietzen F.
        • Wiemer M.
        • DXV405 Study Group
        Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures.
        Am Heart J. 2009; 158: 822-828
        • Poggio E.D.
        • Nef P.C.
        • Wang X.
        • Greene T.
        • Van Lente F.
        • Dennis V.W.
        • Hall P.M.
        Performance of the Cockcroft-Gault and Modification of Diet in Renal Disease equations in estimating GFR in ill hospitalized patients.
        Am J Kidney Dis. 2005; 46: 242-252
        • Aspelin P.
        • Aubry P.
        • Fransson S.G.
        • Strasser R.
        • Willenbrock R.
        • Berg K.J.
        • Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar and Low-Osmolar Non-Ionic Contrast Media Study Investigators
        Nephrotoxic effects in high-risk patients undergoing angiography.
        N Engl J Med. 2003; 348: 491-499
        • Treitl M.
        • Rupprecht H.
        • Wirth S.
        • Korner M.
        • Reiser M.
        • Rieger J.
        Assessment of renal vasoconstriction in vivo after intra-arterial administration of the isosmotic contrast medium iodixanol compared to the low-osmotic contrast medium iopamidol.
        Nephrol Dial Transplant. 2009; 24: 1478-1485
        • Rudnick M.R.
        • Goldfarb S.
        • Wexler L.
        • Ludbrook P.A.
        • Murphy M.J.
        • Halpern E.F.
        • Hill J.A.
        • Winniford M.
        • Cohen M.B.
        • VanFossen D.B.
        Nephrotoxicity of ionic and nonionic contrast media in 1196 patients: a randomized trial.
        Kidney Int. 1995; 47: 254-261
        • Solomon R.J.
        • Natarajan M.K.
        • Doucet S.
        • Sharma S.K.
        • Staniloae C.S.
        • Katholi R.E.
        • Gelormini J.L.
        • Labinaz M.
        • Moreyra A.E.
        • Investigators of the CARE Study
        Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease.
        Circulation. 2007; 115: 3189-3196
        • Davidson C.J.
        • Laskey W.K.
        • Hermiller J.B.
        • Harrison J.K.
        • Matthai W.
        • Vlietstra R.E.
        • Brinker J.A.
        • Kereiakes D.J.
        • Muhlestein J.B.
        • Lansky A.
        • Popma J.J.
        • Buchbinder M.
        • Hirshfeld J.W.
        Randomized trial of contrast media utilization in high-risk PTCA.
        Circulation. 2000; 101: 2172-2177
        • Ribichini F.
        • Graziani M.
        • Gambaro G.
        • Pasoli P.
        • Pighi M.
        • Pesarini G.
        • Abaterusso C.
        • Yabarek T.
        • Brunelleschi S.
        • Rizzotti P.
        • Lupo A.
        • Vassanelli C.
        Early creatinine shifts predict contrast-induced nephropathy and persistent renal damage after angiography.
        Am J Med. 2010; 123: 755-763
        • Newhouse J.H.
        • Kho D.
        • Rao Q.A.
        • Starren J.
        Frequency of serum creatinine changes in the absence of iodinated contrast material: implications for studies of contrast nephrotoxicity.
        AJR Am J Roentgenol. 2008; 191: 376-382
        • Feltes C.M.
        • Van Eyk J.
        • Rabb H.
        Distant-organ changes after acute kidney injury.
        Nephron Physiol. 2008; 109: 80-84
        • Stevens M.A.
        • McCullough P.A.
        • Tobin K.J.
        • Speck J.P.
        • Westveer D.C.
        • Guido-Allen D.A.
        • Timmis G.C.
        • O'Neill W.W.
        A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy: results of the P.R.I.N.C.E. study.
        J Am Coll Cardiol. 1999; 33: 403-411
        • Trivedi H.S.
        • Moore H.
        • Nasr S.
        • Aggarwal K.
        • Agrawal A.
        • Goel P.
        • Hewett J.
        A randomized prospective trial to assess the role of saline hydration on the development of contrast nephrotoxicity.
        Nephron Clin Pract. 2003; 93: C29-C33