The population's aging underscores the need to understand the process and define the
physiologic markers predictive of healthy longevity. The findings that aging is associated
with a progressive decrease in heart rate variability (HRV), an index of autonomic
function, suggests that longevity might depend on preservation of autonomic function.
However, little is known about late life changes. We assessed the relation between
autonomic function and longevity by a cross-sectional study of HRV of 344 healthy
subjects, 10 to 99 years old. The HRV was determined from 24-hour Holter records,
using 4 time domain measures of HRV (the root mean square of the successive normal
sinus RR interval difference [rMSSD], percentage of successive normal sinus RR intervals
>50 ms [pNN50], standard deviation of all normal sinus RR intervals during a 24-hour
period [SDNN], and standard deviation of the averaged normal sinus RR intervals for
all 5-minute segments [SDANN]). Autonomic modulation of the 4 measures differs, permitting
distinctions between changes in HRV–parasympathetic function, using rMSSD and pNN50,
and HRV–sympathetic function using SDNN and SDANN. Decade values were compared using
analysis of variance and t-multiple comparison testing. The HRV of all measures decreases
rapidly from the second to fifth decades. It then slows. The HRV–sympathetic function
continues to decrease throughout life. In contrast, the decrease in HRV–parasympathetic
function reaches its nadir in the eighth decade, followed by reversal and a progressive
increase to higher levels (p <0.05), more characteristic of a younger population.
In conclusion, healthy longevity depends on preservation of autonomic function, in
particular, HRV–parasympathetic function, despite the early age-related decrease.
The eighth decade reversal of the decrease in HRV–parasympathetic function and its
subsequent increase are key determinants of longevity. Persistently high HRV in the
elderly represents a marker predictive of longevity.
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References
- Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades.J Am Coll Cardiol. 1998; 31: 593-601
- Changes in heart rate variability with age.PACE. 1996; 19: 1863-1866
- Baseline heart rate variability in healthy centenarians: differences compared with aged subjects (>75 years old).Clin Sci. 1999; 97: 579-584
- Power spectral analysis of heart rate in subjects over a hundred years old.Int J Cardiol. 1998; 63: 53-61
- And the multicenter post-infarction research group: decreased heart rate variability and its association with increased mortality after acute myocardial infarction.Am J Cardiol. 1987; 59: 256-262
- Time domain measurements of heart rate variability.Cardiol Clin. 1992; 10: 487-498
- New method for assessing cardiac parasympathetic activity using 24 hour electrocardiograms.Br Heart J. 1984; 52: 396-402
- Heart rate variability.Clin Cardiol. 1990; 13: 570-576
- Differential changes of autonomic nervous system function with age in man.Am J Med. 1983; 75: 249-258
- Autonomic control of cardiac chronotropic function in man as a function of age: assessment of power spectral analysis of heart rate variability.J Auton Nerv Syst. 1991; 32: 191-198
- Deaths: final data for 2005.Natl Vital Stat Rep. 2008; 56: 102
- Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load.Am J Physiol Heart Circ Physiol. 2006; 291: H451-H458
- Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.FASEB J. 2006; 20: 632-637
- Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.Circ Res. 2005; 96: 412-418
- Insulin/IGF-I signaling pathway: an evolutionary conserved mechanism of longevity from yeast to humans.Am J Physiol Endocrinol Metab. 2003; 285: E1064-E1071
- Cardiovascular preparticipation screening of competitive athletes: a statement for health professionals from the Sudden Death Committee (clinical cardiology) and Congenital Cardiac Defects Committee (cardiovascular disease in the young), American Heart Association.Circulation. 1996; 94: 850-856
- Low heart rate variability and sudden cardiac death.J Electrocardiol. 1988; 21: S46-S55
- The effects of heart rate, myocardial ischemia and vagal stimulation on the threshold for ventricular fibrillation.Circulation. 1977; 55: 311-317
- Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death.Am Heart J. 2004; 147: 837-840
- Impact of diet-induced weight loss on the cardiac autonomic nervous system in severe obesity.Obes Rev. 2003; 11: 1040-1047
- Oral ascorbic acid in combination with beta-blockers.Tex Heart Inst J. 2007; 34: 268-274
- Polyunsaturated fatty acids and cardiovascular events: a fish tale.Circulation. 2001; 103: 623-625
- n-3 fatty acids, heart rate variability, and sudden cardiac death.Lipids. 2001; 36: S115-S118
Article Info
Publication History
Published online: February 22, 2010
Accepted:
December 3,
2009
Received in revised form:
December 3,
2009
Received:
October 26,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
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- Erratum for Zulfiqar U, et al. “Relation of High Heart Rate Variability to Healthy Longevity” Am J Cardiol 2010;105:1181–1185American Journal of CardiologyVol. 106Issue 1
- Heart Rate Variability and LongevityAmerican Journal of CardiologyVol. 106Issue 6
- PreviewIn their recent report “Relation of High Heart Rate Variability to Healthy Longevity,” Zulfiqar et al1 calculated 4 standard 24-hour time-domain measures of heart rate variability by decade in 344 healthy subjects aged 10 to 99 years. In this cross-sectional study, the investigators observed a sharp increase in the root mean square of the successive normal sinus RR interval difference (rMSSD) and the percentage of successive normal sinus RR intervals >50 ms (pNN50) in the 20 subjects aged >80 years.
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- Holter Heart Rate Variability: Are We Measuring Physical Activity?American Journal of CardiologyVol. 106Issue 3
- PreviewWe congratulate Zulfiqar et al1 for their valuable study demonstrating the relation between high heart rate (HR) variability and healthy longevity. In their report, they discussed HR variability due to autonomic control and nothing else. HR variability obviously is caused by autonomic control, as demonstrated by autonomic blockade (see, e.g., Figure 1 in Tan et al2). Fluctuation of a variable is caused by control mechanisms in steady-state conditions. Control mechanisms, including baroreflex, detect any blood pressure drift and change HR, with a delay to compensate for the drift.
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