Human urotensin II (U-II) is an 11–amnio acid peptide that plays an important role
in hypertension and coronary artery disease. However, because there is no information
on the role of U-II in the development of lone atrial fibrillation (AF), the goal
of this study was to clarify the role of U-II in the development of lone AF. The study
enrolled 42 patients (42.1 ± 4.0 years old) with paroxysmal lone AF and 30 healthy
gender- and age-matched control subjects. The following factors were measured in blood
collected after an overnight fast: glucose, total cholesterol, low-density lipoprotein
cholesterol, triglycerides, high-sensitivity C-reactive protein (hs-CRP), U-II, and
vascular cell adhesion molecule 1 (VCAM-1). U-II levels were significantly higher
in the lone AF than in the control group (4.09 ± 1.28 vs 2.85 ± 0.63 ng/ml, p <0.001).
VCAM-1 levels were also higher in the lone AF than in the control group (337 ± 250
vs 218 ± 117 ng/ml, p = 0.018). In addition, hs-CRP levels were higher in the lone
AF than in the control group (0.88 ± 0.29 mg/dl vs 0.67 ± 0.31 mg/dl, p = 0.004).
Multivariate logistic regression analysis that included U-II, VCAM-1, hs-CP, and conventional
AF risk factors showed that only U-II and hs-CRP were independently associated with
lone AF. In conclusion, the results indicate that increased levels of U-II are associated
with the development of lone AF. Additional studies will be necessary to determine
whether the elevation of U-II is the cause or the result of AF.
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Article Info
Publication History
Accepted:
July 29,
2009
Received in revised form:
July 29,
2009
Received:
April 24,
2009
Footnotes
This research is supported by the National Basic Research Program of China, Beijing, China.
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
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- Erratum for Zhang L, et al. “Relation of Urotensin II Levels to Lone Atrial Fibrillation” Am J Cardiol 2009;104:1704–1707American Journal of CardiologyVol. 105Issue 7
