The Editor's Roundtable: Prehypertension

  • William C. Roberts
    Corresponding author: Tel: 214-820-7911; fax: 214-820-7533
    Editor-in-Chief, The American Journal of Cardiology and Baylor University Medical Center Proceedings, Executive Director, Baylor Heart and Vascular Institute, Baylor University Medical Center, and Dean, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas, Texas
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  • George L. Bakris
    Professor of Medicine, Department of Medicine, University of Chicago, Pritzker School of Medicine, and Director, Hypertensive Diseases Unit, University of Chicago Hospitals, Chicago, Illinois
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  • Henry R. Black
    Clinical Professor of Internal Medicine, Director of Hypertension Research, New York University School of Medicine, NYU Center for the Prevention of Cardiovascular Disease, New York, New York
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  • Domenic A. Sica
    Professor of Medicine and Pharmacology and Chairman, Section of Clinical Pharmacology and Hypertension, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, Virginia
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  • Destry J. Sulkes
    Vice President, Educational Services, Medscape LLC, New York, New York
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      This activity is supported by an educational grant from Bristol-Myers Squibb, New York, New York, and Sanofi-Aventis, Paris, France.
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        • Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
        The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
        National Institutes of Health, Bethesda, Maryland2004 (NIH publication no. 04-5230)
        • Lewington S.
        • Clarke R.
        • Qizilbash N.
        • Peto R.
        • Collins R.
        • Prospective Studies Collaboration
        Age-specific relevance of usual BP to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
        Lancet. 2002; 360: 1903-1913
        • Pletcher M.J.
        • Bibbins-Domingo K.
        • Lewis C.E.
        • Wei G.S.
        • Sidney S.
        • Carr J.J.
        • Vittinghoff E.
        • McCulloch C.E.
        • Hulley S.B.
        Prehypertension during young adulthood and coronary calcium later in life.
        Ann Intern Med. 2008; 149: 91-99
        • Julius S.
        • Nesbtt S.D.
        • Egan B.M.
        • Weber M.A.
        • Michelson E.L.
        • Kaciroti N.
        • Black H.R.
        • Grimm Jr, R.H.
        • Messerli F.H.
        • Oparil S.
        • Schork M.A.
        • Trial of Preventing Hypertension (TROPHY) Study Investigators
        Feasibility of treating prehypertension with an angiotensin-receptor blocker.
        N Engl J Med. 2006; 354: 1685-1697
        • Hsia J.
        • Margolis K.L.
        • Eaton C.B.
        • Wenger N.K.
        • Allison M.
        • Wu L.L.
        • LaCroix Andrea Z.
        • Black H.R.
        Prehypertension and cardiovascular disease risk in the Women's Health Initiative.
        Circulation. 2007; 115: 855-860
        • Elliott W.J.
        • Young P.E.
        • DeVivo L.
        • Feldstein J.
        • Black H.
        Comparison of two sphygmomanometers that may replace mercury in the healthcare workplace.
        Blood Press Monit. 2007; 12: 23-28
        • Cesana G.DeVitoG.
        • Ferrario M.
        • Libretti A.
        • Mancia G.
        • Mocarelli P.
        • Sega R.
        • Velaqussa F.
        • Zanchetti A.
        Ambulatory blood pressure normalcy: the PAMELA study.
        J Hypertens. 1991; 9: S17-S23
        • Pickering T.G.
        • Hall J.E.
        • Appel L.J.
        • Falkner B.E.
        • Graves J.
        • Hill M.N.
        • Jones D.W.
        • Kurtz T.
        • Sheps S.G.
        • Roccella E.J.
        Recommendations for BP measurement in humans and experimental animals: part I: BP measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High BP Research.
        Hypertension. 2005; 45: 142-161
        • Skov K.
        • Eiskjaer H.
        • Hansen H.E.
        • Madsen J.K.
        • Kvist S.
        • Mulvany M.J.
        Treatment of young subjects at high familial risk of future hypertension with an angiotensin-receptor blocker.
        Hypertension. 2007; 50: 89-95
        • Grimm Jr, R.H.
        • Grandits G.A.
        • Cutler J.A.
        • Stewart A.L.
        • McDonald R.H.
        • Svendsen K.
        • Prineas R.J.
        • Liebson P.R.
        Relationships of quality-of-life measures to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension study.
        Arch Intern Med. 1997; 157: 638-648
        • Margolis K.L.
        • Ray R.
        • Van Horn L.
        • Manson J.
        • Allison M.
        • Black H.R.
        • Beresford S.
        • Connelly S.
        • Curb D.
        • Grimm R.
        • Kotchen T.
        • Kuller L.
        • Smoller S.
        • Thomson C.
        • Torrner J.
        Effect of calcium and vitamin D supplementation on blood pressure in postmenopausal women: results from the Women's Health Initiative clinical trial of calcium-vitamin D supplementation.
        Hypertension. 2008; 52: 1
        • Tobian L.
        • Lange J.
        • Ulm K.
        • Wold L.
        • Iwai J.
        Potassium reduces cerebral hemorrhage and death rate in hypertensive rats, even when BP is not lowered.
        Hypertension. 1985; 7: I110-I114
        • DeFronzo R.A.
        • Sherwin R.S.
        • Feliq P.
        • Bia M.
        Nonuremic diabetic hyperkalemia.
        Arch Intern Med. 1977; 137: 842-843
        • Bakris G.
        • Molitch M.
        • Hewkin A.
        • Kipnes M.
        • Sarafidis P.
        • Fakouhi K.
        • Bacher P.
        • Sowers J.
        • STAR Investigators
        Differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people with metabolic syndrome.
        Diabetes Care. 2006; 29: 2592-2597
        • Savage P.J.
        • Pressel S.L.
        • Curb J.D.
        • Schron E.B.
        • Applegate W.B.
        • Black H.R.
        • Cohen J.
        • Davis B.R.
        • Frost P.
        • Smith W.
        • Gonzalez N.
        • Guthrie G.P.
        • Oberman A.
        • Rutan G.
        • Probstfield J.L.
        • Stamler J.
        Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: the Systolic Hypertension in the Elderly Program.
        Arch Intern Med. 1998; 158: 741-751
        • Barzilay J.I.
        • Davis B.R.
        • Cutler J.A.
        • Pressel S.L.
        • Whelton P.K.
        • Basile J.
        • Margolis K.L.
        • Ong S.T.
        • Sadler L.S.
        • Summerson J.
        • ALLHAT Collaborative Research Group
        Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
        Arch Intern Med. 2006; 166: 2191-2201
        • Jamerson K.
        • Weber M.A.
        • Bakris G.L.
        • Dahlöf B.
        • Pitt B.
        • Shi V.
        • Hester A.
        • Gupte J.
        • Gatlin M.
        • Velazquez E.J.
        • ACCOMPLISH Trial Investigators
        Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.
        N Engl J Med. 2008; 359: 2417-2428
        • Elliott W.J.
        • Weir D.R.
        • Black H.R.
        Cost-effectiveness of the lower treatment goal (of JNC VI) for diabetic hypertensive patients.
        Arch Intern Med. 2000; 160: 1277-1283
        • Garg J.P.
        • Elliott W.J.
        • Folker A.
        • Izhar M.
        • Black H.R.
        • Rush University Hypertension Service
        Resistant hypertension revisited: a comparison of two university-based cohorts.
        Am J Hypertens. 2005; 18: 619-626