The relation between cholesteryl ester transfer protein (CETP) levels and atherosclerosis
is controversial. We examined whether the serum CETP levels were associated with subclinical
atherosclerosis, independent of its most common gene variant, in a sample of Japanese
men. A population-based cross-sectional study of 250 Japanese men aged 40 to 49 years
was conducted to assess the intima-media thickness of the carotid artery, coronary
artery calcium, serum CETP levels, and the CETP D442G gene variant. Compared with
the lowest CETP quartile, the multivariate adjusted odds ratio for coronary artery
calcium was 0.77 (95% confidence interval 0.18 to 3.36), 0.96 (95% confidence interval
0.27 to 3.40), and 3.49 (95% confidence interval 1.05 to 11.6) with increasing CETP
quartiles. The serum CETP quartiles were also positively associated with the intima-media
thickness of the carotid artery (adjusted mean 602, 616, 615, and 646 μm for the lowest
to top quartile, respectively). The findings remained unchanged after additional adjustment
for the CETP D442G gene variant. No significant difference was found in the prevalence
of coronary artery calcium or in the mean intima-media thickness of the carotid artery
between participants with and without the CETP D442G gene variant.
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Article info
Publication history
Published online: July 21, 2009
Accepted:
May 2,
2009
Received in revised form:
May 2,
2009
Received:
March 31,
2009
Footnotes
This research was supported by Grants R01 HL68200 and HL071561 from the National Institutes of Health, Bethesda, Maryland; by a Grant-in-Aid for Scientific Research, Grants C18590595 and C20590670, from the Japan Society for the Promotion of Science, Tokyo, Japan; and by a Grant-in-Aid for Scientific Research, Grant A13307016, by the Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.
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© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
