Determinants of Cardiorespiratory Fitness in Men Aged 42 to 60 Years With and Without Cardiovascular Disease

      Good cardiorespiratory fitness has been found to protect against cardiovascular diseases and type 2 diabetes. The purpose of this study was to investigate determinants of directly measured cardiorespiratory fitness (maximal oxygen uptake [Vo2max]), including age, body composition, prevalent diseases, cardiovascular and pulmonary functions, biochemical factors, physical activity, nutrition, smoking, and alcohol consumption, in a population-based study of 936 men 42 to 60 years of age. Variables that had the strongest direct associations with Vo2max (milliliters per minute) in a linear multivariate step-up regression model were body weight, heart rate at maximal exercise, mean intensity and frequency of conditioning physical activity, intake of carbohydrates, blood hemoglobin, and forced expiratory volume in 1 second. The strongest inverse associations with Vo2max were heart rate at rest, age, fasting serum insulin, waist-to-hip ratio, coronary heart disease, and asthma. This model accounted for 67% of the variation of Vo2max. In conclusion, mean intensity, frequency, and duration of conditioning physical activity were associated directly with Vo2max. However, measurements of the function of pulmonary and cardiovascular systems, carbohydrate intake, and body composition were powerful determinants of cardiorespiratory fitness, especially in older middle-aged men.
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        • Leon A.S.
        • Jacobs D.R.
        • DeBacker G.
        • Taylor H.L.
        Relationship of physical characteristics and life habits to treadmill exercise capacity.
        Am J Epidemiol. 1981; 113: 653-660
        • Kohl H.W.
        • Blair S.N.
        • Paffenbarger Jr, R.S.
        • Macera C.A.
        • Kronenfeld J.J.
        A mail survey of physical activity habits as related to measured physical fitness.
        Am J Epidemiol. 1988; 127: 1228-1239
        • Jackson A.S.
        • Beard E.F.
        • Wier L.T.
        • Ross R.M.
        • Stuteville J.E.
        • Blair S.N.
        Changes in aerobic power of men ages 25–70 yr.
        Med Sci Sports Exerc. 1995; 27: 113-120
        • Bruce R.A.
        • Kusumi F.
        • Hosmer D.
        Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease.
        Am Heart J. 1973; 85: 546-562
        • Fletcher G.F.
        • Balady G.J.
        • Amsterdam E.A.
        • Chaitman B.
        • Eckel R.
        • Fleg J.
        • Froelicher V.F.
        • Leon A.S.
        • Piña I.L.
        • Rodney R.
        • et al.
        Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association.
        Circulation. 2001; 104: 1694-1740
        • Bouchard C.
        • Boulay M.R.
        • Simoneau J.A.
        • Bouchard C.
        • Boulay M.R.
        • Simoneau J.A.
        Heredity and trainability of aerobic and anaerobic performances.
        Sports Med. 1988; 5: 69-73
        • Rankinen T.
        • Perusse L.
        • Rauramaa R.
        • Rivera M.A.
        • Wolfarth B.
        • Bouchard C.
        The human gene map for performance and health-related fitness phenotypes.
        Med Sci Sports Exerc. 2001; 33: 855-867
        • Penny W.J.
        • Mir M.A.
        Cardiorespiratory response to exercise before and after acute beta-adrenoreceptor blockade in nonsmokers and smokers.
        Int J Cardiol. 1986; 11: 293-304
        • Blair S.N.
        • Kannel W.B.
        • Kohl H.W.
        • Goodyear N.
        • Wilson P.W.
        Surrogate measures of physical activity and physical fitness.
        Am J Epidemiol. 1989; 129: 1145-1156
        • Sandvik L.
        • Erikssen G.
        • Thaulow E.
        Long term effects of smoking on physical fitness and lung function: a longitudinal study of 1393 middle aged Norwegian men for seven years.
        BMJ. 1995; 311: 715-718
        • Ogawa T.
        • Spina R.J.
        • Martin III, W.H.
        • Kohrt W.M.
        • Schechtman K.B.
        • Holloszy J.O.
        • Ehsani A.A.
        Effects of aging, sex, and physical training on cardiovascular response to exercise.
        Circulation. 1992; 86: 494-503
        • Tager I.B.
        • Hollenberg M.
        • Satariano W.A.
        Association between self-reported leisure-time physical activity and measures of cardiorespiratory fitness in an elderly population.
        Am J Epidemiol. 1998; 147: 921-931
        • Lakka T.A.
        • Venäläinen J.M.
        • Rauramaa R.
        • Salonen R.
        • Tuomilehto J.
        • Salonen J.T.
        Relation of physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men.
        N Eng J Med. 1994; 330: 1549-1554
        • Salonen J.T.
        • Lakka T.A.
        Intra-person variability of various physical activity assessments in the Kuopio Ischaemic Heart Disease Risk Factor Study.
        Int J Epidemiol. 1992; 21: 467-472
        • Lakka T.A.
        • Salonen J.T.
        The physical activity questionnaires of the Ischaemic Heart Disease Study (KIHD).
        Med Sci Sports Exerc. 1997; 29: S46-S59
        • Kauhanen J.
        • Julkunen J.
        • Salonen J.T.
        Coping with inner feelings and stress: heavy alcohol use in the context of alexithymia.
        Behav Med. 1992; 18: 121-126
        • Laukkanen J.A.
        • Kurl S.
        • Rauramaa R.
        • Lakka T.A.
        • Venäläinen J.M.
        • Salonen J.T.
        Systolic blood pressure response to exercise testing is related to the risk of acute myocardial infarction in middle-aged men.
        Eur J Cardiovas Prev Rehabil. 2006; 13: 421-428
        • Salonen J.T.
        • Salonen R.
        • Seppanen K.
        • Rauramaa R.
        • Tuomilehto J.
        HDL, HDL2, HDL3 subfractions, and the risk of acute myocardial infarction: a prospective population study in eastern Finnish men.
        Circulation. 1991; 84: 129-139
        • Salonen J.T.
        • Nyyssonen K.
        • Korpela H.
        • Tuomilehto J.
        • Seppänen R.
        • Salonen R.
        High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.
        Circulation. 1992; 86: 803-811
        • Sobolski J.C.
        • Kolesar J.J.
        • Kornitzer M.D.
        • De Backer G.G.
        • Mikes Z.
        • Dramaix M.M.
        • Degre S.G.
        • Denolin H.F.
        Physical fitness does not reflect physical activity patterns in middle-aged workers.
        Med Sci Sports Exerc. 1988; 20: 6-13
        • Rauramaa R.
        • Tuomainen P.
        • Väisänen S.
        • Rankinen T.
        Physical activity and health-related fitness in middle-aged men.
        Med Sci Sports Exerc. 1995; 27: 707-712
        • Seals D.R.
        • Hagberg J.M.
        • Hurley B.F.
        • Ehsani A.A.
        • Holloszy J.O.
        Endurance training in older men and women.
        J Appl Physiol. 1984; 57: 1024-1029
        • Wenger H.A.
        • Bell G.J.
        The interactions of intensity, frequency and duration of exercise training in altering cardiorespiratory fitness.
        Sports Med. 1986; 3: 345-356
        • Dionne F.T.
        • Turcotte L.
        • Thibault M.C.
        • Boulay M.R.
        • Skinner J.S.
        • Bouchard C.
        Mitochondrial DNA sequence polymorphism, VO2max and response to endurance training.
        Med Sci Sports Exerc. 1991; 23: 177-185
        • Saltin B.
        • Strange S.
        Maximal oxygen uptake: “old” and “new” arguments for a cardiovascular limitation.
        Med Sci Sports Exerc. 1992; 24: 30-37
        • Morris C.K.
        • Froelicher V.F.
        Cardiovascular benefits of improved exercise capacity.
        Sports Med. 1993; 16: 225-236
        • Hagberg J.M.
        • Allen W.K.
        • Seals D.R.
        • Hurley B.F.
        • Ehsani A.A.
        • Holloszy J.O.
        A hemodynamic comparison of young and older endurance athletes during exercise.
        J Appl Physiol. 1985; 58: 2041-2046
        • Shvartz E.
        • Reibold R.C.
        Aerobic fitness norms for males and females aged 6 to 75 years: a review.
        Aviat Space Environ Med. 1990; 61: 3-11
        • Coyle E.F.
        Substrate utilization during exercise in active people.
        Am J Clin Nutr. 1995; 61: 968S-979S
        • Laukkanen J.A.
        • Lakka T.A.
        • Rauramaa R.
        • Kuhanen R.
        • Venäläinen J.M.
        • Salonen R.
        • Salonen J.T.
        Cardiovascular fitness as a predictor of mortality in men.
        Arch Intern Med. 2001; 161: 825-831