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Caffeinated Coffee Consumption, Cardiovascular Disease, and Heart Valve Disease in the Elderly (from the Framingham Study)

Published:September 15, 2008DOI:https://doi.org/10.1016/j.amjcard.2008.07.046
      The relation between caffeinated coffee consumption and heart disease morbidity and mortality is of great interest given the extensive use of this beverage. A recent prospective epidemiologic study found a strong protective association in elderly subjects without moderate to severe hypertension in the NHANES. To test this association in the Framingham Heart Study population, in which cardiovascular risk factors and health behaviors were carefully documented, Cox regression analyses were conducted for 1,354 subjects aged 65.4 to 96.6 years at study entry. There were 210 deaths from cardiovascular disease and 118 from coronary heart disease (CHD) during 10.1 years of follow-up. A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP) <160 mm Hg and diastolic BP <100 mm Hg. The decrease in risk of CHD mortality for any caffeinated coffee versus none was 43% (95% confidence interval 9 to 64). This decreased risk appeared to be caused primarily by an inverse prospective relation between caffeinated coffee consumption and the development or progression of heart valve disease. The decrease in risk of heart valve disease for subjects with systolic BP <160 mm Hg and diastolic BP <100 mm Hg for any caffeinated coffee versus none was 43% (95% confidence interval 4 to 66). In conclusion, caffeinated coffee consumption was associated with lower risk of CHD mortality and heart valve disease development or progression in older Framingham subjects without moderate or severe hypertension.
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      References

        • Greenberg J.A.
        • Dunbar C.C.
        • Kokolis S.
        • Kokolis R.
        • Schnoll R.
        • Kassotis J.
        Caffeinated-beverage intake and risk of coronary heart disease mortality in the elderly.
        Am J Clin Nutr. 2007; 85: 392-398
        • Rosner S.A.
        • Akesson A.
        • Stampfer M.J.
        • Wolk A.
        Coffee consumption and risk of myocardial infarction among older Swedish women.
        Am J Epidemiol. 2007; 165: 288-293
        • Andersen L.F.
        • Jacobs Jr., D.R.
        • Carlsen M.H.
        • Blomhoff R.
        Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study.
        Am J Clin Nutr. 2006; 83: 1039-1046
        • Silletta M.G.
        • Marfisi R.
        • Levantesi G.
        • Boccanelli A.
        • Chieffo C.
        • Franzosi M.
        • Geraci E.
        • Maggioni A.P.
        • Nicolosi G.
        • Schweiger C.
        • et al.
        • GISSI Prevenzione Investigators
        Coffee consumption and risk of cardiovascular events after acute myocardial: results from the GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico) Prevenzione Trial.
        Circulation. 2007; 116: 2944-2951
        • Lopez-Garcia E.
        • van Dam R.M.
        • Li T.Y.
        • Rodriguez-Artalejo F.
        • Hu F.B.
        The relationship of coffee consumption with mortality.
        Ann Intern Med. 2008; 148: 904-914
        • Happonen P.
        • Voutilainen S.
        • Salonen J.T.
        Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men.
        J Nutr. 2004; 134: 2381-2386
        • Dawber T.R.
        • Meadors G.F.
        • Moore Jr, F.E.
        Epidemiological approaches to heart disease: the Framingham Study.
        Am J Public Health. 1951; 41: 279-281
        • Chobanian A.V.
        • Bakris G.L.
        • Black H.R.
        • Cushman W.C.
        • Green L.A.
        • Izzo Jr, J.L.
        • Jones D.W.
        • Materson B.J.
        • Oparil S.
        • Wright Jr, J.T.
        • Roccella E.J.
        • National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
        • National High Blood Pressure Education Program Coordinating Committee
        The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
        JAMA. 2003; 289: 2560-2572
        • Ainsworth B.E.
        • Haskell W.L.
        • Whitt M.C.
        • Irwin M.L.
        • Swartz A.M.
        • Strath S.J.
        • O'Brien W.L.
        • Bassett Jr., D.R.
        • Schmitz K.H.
        • Emplaincourt P.O.
        • Jacobs Jr., D.R.
        • Leon A.S.
        Compendium of physical activities: an update of activity codes and MET intensities.
        Med Sci Sports Exerc. 2000; 32: S498-S504
        • Pate P.R.
        • Pratt M.
        • Blair S.N.
        • Haskell W.L.
        • Macera C.A.
        • Bouchard C.
        • Buchner D.
        • Ettinger W.
        • Heath G.W.
        • King A.C.
        Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine.
        JAMA. 1995; 73: 402-407
        • Cox D.R.
        Regression models and life tables.
        J R Stat Soc B. 1972; 34: 187-220
        • Norusis M.J.
        SPSS 14.0. Advanced Statistical Procedures Companion.
        in: Prentice Hall, Saddle River, NJ2005: 150-170
        • Klatsky A.L.
        • Koplik S.
        • Kipp H.
        • Friedman G.D.
        The confounded relation of coffee drinking to coronary artery disease.
        Am J Cardiol. 2008; 101: 825-827
        • Das P.
        • Pocock C.
        • Chambers J.
        The patient with a systolic murmur: severe aortic stenosis may be missed during cardiovascular examination.
        QJM. 2000; 93: 685-688
        • Rosamond W.
        • Flegal K.
        • Friday G.
        • Furie K.
        • Go A.
        • Greenlund K.
        • Haase N.
        • Ho M.
        • Howard V.
        • Kissela B.
        • et al.
        • American Heart Association Statistics Committee and Stroke Statistics Subcommittee
        Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
        Circulation. 2007; 115: e69-e171
        • Noordzij M.
        • Uiterwaal C.S.
        • Arends L.R.
        • Kok F.J.
        • Grobbee D.E.
        • Geleijnse J.M.
        Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials.
        J Hypertens. 2005; 23: 921-928
        • Winkelmayer W.C.
        • Stampfer M.J.
        • Willett W.C.
        • Curhan G.C.
        Habitual caffeine intake and the risk of hypertension in women.
        JAMA. 2005; 294: 2330-2335
        • Nkomo V.T.
        • Gardin J.M.
        • Skelton T.N.
        • Gottdiener J.S.
        • Scott C.G.
        • Enriquez-Sarano M.
        Burden of valvular heart diseases: a population-based study.
        Lancet. 2006; 368: 1005-1011
        • Aronow W.S.
        • Kronzon I.
        Prevalence and severity of valvular aortic stenosis determined by Doppler echocardiography and its association with echocardiographic and electrocardiographic left ventricular hypertrophy and physical signs of aortic stenosis in elderly patients.
        Am J Cardiol. 1991; 67: 776-777
        • Roberts W.C.
        • Ko J.M.
        Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation.
        Circulation. 2005; 111: 920-925
        • Colli A.
        • Gherli T.
        • Mestres C.A.
        • Pomar J.L.
        Degeneration of native and tissue prosthetic valve in aortic position: do statins play an effective role in prevention?.
        Int J Cardiol. 2007; 116: 144-152
        • Halvorsen B.L.
        • Carlsen M.H.
        • Phillips K.M.
        • Bohn S.K.
        • Holte K.
        • Jacobs Jr., D.R.
        • Blomhoff R.
        Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States.
        Am J Clin Nutr. 2006; 84: 95-135
        • Horrigan L.A.
        • Kelly J.P.
        • Connor T.J.
        Immunomodulatory effects of caffeine: friend or foe?.
        Pharmacol Ther. 2006; 111: 877-892
        • Otto C.M.
        • Kuusisto J.
        • Reichenbach D.D.
        • Gown A.M.
        • O'Brien K.D.
        Characterization of the early lesion of ‘degenerative' valvular aortic stenosis.
        Circulation. 1994; 90: 844-853
        • Olsson M.
        • Dalsgaard C.J.
        • Haegerstrand A.
        • Rosenqvist M.
        • Ryden L.
        • Nilsson J.
        Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves.
        J Am Coll Cardiol. 1994; 23: 1162-1170
        • Sánchez P.L.
        • Santos J.L.
        • Kaski J.C.
        • Cruz I.
        • Arribas A.
        • Villacorta E.
        • Cascon M.
        • Palacios I.F.
        • Martin-Luengo C.
        • Grupo AORTICA (Grupo de Estudio de la Estenosis Aórtica)
        Relation of circulating C-reactive protein to progression of aortic valve stenosis.
        Am J Cardiol. 2006; 97: 90-93
        • Gerber I.L.
        • Stewart R.A.
        • Hammett C.J.
        • Legget M.E.
        • Oxenham H.
        • West T.M.
        • French J.K.
        • White H.D.
        Effect of aortic valve replacement on C-reactive protein in nonrheumatic aortic stenosis.
        Am J Cardiol. 2003; 92: 1129-1132
        • Rall T.W.
        The xanthines.
        in: Gilman A.G. Goodman L.S. Gilman A. The Pharmocological Basis of Therapeutics. Macmillan, New York1986: 592-607
        • Mosqueda-Garcia R.
        • Tseng C.J.
        • Biaggioni I.
        • Robertson R.M.
        • Robertson D.
        Effects of caffeine on baroreflex activity in man.
        Clin Pharmacol Ther. 1990; 48: 568-574
        • Khani B.R.
        • Ye W.
        • Terry P.
        • Wolk A.
        Reproducibility and validity of major dietary patterns among Swedish women assessed with a food-frequency questionnaire.
        J Nutr. 2004; 135: 1541-1544