Despite clinical trial evidence supporting the use of antiplatelets, angiotensin-converting
enzyme inhibitors, and statins for cardiovascular risk reduction in high-risk patients,
use of such therapies in real-world outpatients in the prospective Vascular Protection
Registry and the Guidelines Oriented Approach to Lipid Lowering Registry was suboptimal
(78%, 55%, and 75%, respectively). The most frequent reason physicians cited for nonprescription
of statins (33%) was that patients were not high risk enough and/or current guidelines
did not support statin use. In conclusion, outpatients at high cardiovascular risk
continue to be undertreated as a result of a combination of physician underestimation
of cardiovascular risk (knowledge gap) and barriers to implementation of evidence-based
therapy (practice gap).
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Article info
Publication history
Published online: August 19, 2008
Accepted:
June 30,
2008
Received in revised form:
June 30,
2008
Received:
January 11,
2008
Footnotes
This work was supported by the Canadian Heart Research Centre, Toronto, Ontario, Canada, Pfizer, Kirkland, Quebec, Canada, Sanofi Aventis, Laval, Quebec, Canada, and Astra Zeneca, Mississauga, Canada. Drs. Leiter, Fitchett, Langer, and Goodman have received speaker/consulting honoraria and/or research grant support from the co-sponsors.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.