Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated
with increased cardiovascular events in patients with type 2 diabetes, whereas higher
levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of
cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic
factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425
men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening
program were studied. CRF was measured using peak oxygen uptake with expired gas analysis
during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein
(CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen
(r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA)
antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r =
−0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white
blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF
(all p <0.05). In separate multivariable linear regression models that adjusted for
age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure,
CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen
(β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were
each inversely associated with CRF. Each MET increment higher peak oxygen uptake was
associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95%
confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In
conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors,
and LP(a) in men with type 2 diabetes.
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Article Info
Publication History
Published online: July 01, 2008
Accepted:
May 1,
2008
Received in revised form:
May 1,
2008
Received:
February 2,
2008
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
