The goal of this study was to compare the impact of differences in waist circumference
(WC) defined according to the International Diabetes Federation (IDF) and the Adult
Treatment Panel III (ATP III) and body mass index (BMI) on cardiovascular disease
risk factors in 402 apparently healthy volunteers of European ancestry. Consequently,
measurements were made of the WC, BMI, blood pressure, glucose, and lipid components
of metabolic syndrome (MS) and insulin-mediated glucose uptake. Subjects were divided
according to WC (IDF and ATP III criteria) and by normal weight, overweight, or obesity
using BMI, and comparisons were made of the effect of these different indexes of adiposity
on cardiovascular disease risk factors. The results indicated that WC and BMI significantly
correlated (p <0.001) and were associated with differences in insulin-mediated glucose
uptake to a similar degree in men (r = 0.57 and r = 0.59) and women (r = 0.53 and
r = 0.52). Prevalences of MS were essentially identical irrespective of the measure
of WC used (ATP III vs IDF), as were metabolic characteristics of those classified
using IDF or ATP III criteria. Cardiovascular disease risk factor status did not vary
substantially when subjects were divided on the basis of WC or BMI. In conclusion,
prevalences of MS or cardiovascular disease risk factors did not vary as a function
of differences in IDF and ATP III criteria for WC. BMI identified individuals at increased
cardiovascular disease risk as effectively as determination of WC.
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Article info
Publication history
Published online: May 12, 2008
Accepted:
February 26,
2008
Received in revised form:
February 26,
2008
Received:
November 8,
2007
Footnotes
This work was supported in part by research grants from the National Institutes of Health, Bethesda, Maryland (RR000070), and Stanford University School of Medicine Dean's Fellowship (MCR), Stanford, California.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
